Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Hector L. Franco"'
Autor:
Michael R. Kelly, Kamila Wisniewska, Matthew J. Regner, Michael W. Lewis, Andrea A. Perreault, Eric S. Davis, Douglas H. Phanstiel, Joel S. Parker, Hector L. Franco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Super-enhancers and their associated transcription factor networks have been shown to influence ovarian cancer biology. Here, based on an integrated set of genomic and epigenomic datasets, the authors identify clinically relevant super-enhancers ampl
Externí odkaz:
https://doaj.org/article/d9536a46a27c422385327a9c778355b9
Autor:
Hyunsoo Kim, Kamila Wisniewska, Matthew J. Regner, Aatish Thennavan, Philip M. Spanheimer, Hector L. Franco
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13053 (2023)
Male breast cancer represents about 1% of all breast cancer diagnoses and, although there are some similarities between male and female breast cancer, the paucity of data available on male breast cancer makes it difficult to establish targeted therap
Externí odkaz:
https://doaj.org/article/a669c4bf6d75475b99451811a54a7867
Publikováno v:
FEBS Open Bio, Vol 11, Iss 6, Pp 1537-1551 (2021)
Precise genome engineering of living cells has been revolutionized by the introduction of the highly specific and easily programmable properties of the clustered regularly interspaced short palindromic repeats (CRISPR) technology. This has greatly ac
Externí odkaz:
https://doaj.org/article/ba9a01acea6c4776a594080b4e3dd4f2
Autor:
Yuanxin Xi, Jiejun Shi, Wenqian Li, Kaori Tanaka, Kendra L. Allton, Dana Richardson, Jing Li, Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Luis Della Coletta, Melissa S. Simper, Khandan Keyomarsi, Jianjun Shen, Mark T. Bedford, Xiaobing Shi, Michelle C. Barton, W. Lee Kraus, Wei Li, Sharon Y. R. Dent
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Epigenetic regulators are frequently mutated or aberrantly expressed in a variety of cancers, leading to altered transcription states that result in changes in cell identity, behavior, and response to therapy. Results To define al
Externí odkaz:
https://doaj.org/article/b6b28abd82404ab384f6ee9983f4d6f1
Autor:
Hyunsoo Kim, Austin Whitman, Kamila Wisniewska, Susana Garcia-Recio, Rasha Kakati, Hector L. Franco, Charles M. Perou, Philip Spanheimer
Publikováno v:
Cancer Research. 83:PD4-08
A Novel Single Cell Model of Tamoxifen Response in Primary Human Breast Tumors Austin Whitman, Hyunsoo Kim, Kamila Wisniewska, Rasha Kakati, Susana Garcia Recio, Hector Franco, Charles Perou, Philip Spanheimer Background: Resistance to endocrine ther
Publikováno v:
Cancer Research. 83:P6-12
Approximately 75% of breast cancers are driven by the estrogen receptor alpha (ER), and despite the advent of endocrine therapy to block ER signaling pathways, a significant portion of women develop resistance to these drugs. The pioneer factor FOXA1
Autor:
Matthew J. Regner, Aatish Thennavan, Kamila Wisniewska, Susana Garcia-Recio, Raul Mendez-Giraldez, Philip Spanheimer, Charles M. Perou, Hector L. Franco
Publikováno v:
Cancer Research. 83:P5-14
Identification of the cis-regulatory elements controlling oncogenic transcriptional programs is critical to understanding tumor biology. To find cis-regulatory elements (i.e. gene enhancers) of oncogenic dependencies in Triple-Negative Breast Cancers
Autor:
Shen Li, Hector L. Franco, Hyunsoo Kim, Rosemary N. Plagens, Raul Mendez-Giraldez, Colby Tubbs, Venkat Malladi, Joseph Garay
Publikováno v:
Cancer Research. 83:P6-12
ER-positive breast cancers compose most breast cancers at the time of diagnosis and are primarily driven by mitogenic estrogen signaling. In ER-positive breast cancers, the pioneer transcription factor FOXA1 plays a critical role in the estrogen rece
Autor:
Hyunsoo Kim, Austin A. Whitman, Kamila Wisniewska, Rasha T. Kakati, Susana Garcia-Recio, Benjamin C. Calhoun, Hector L. Franco, Charles M. Perou, Philip M. Spanheimer
In ER+/HER2- breast cancer, multiple measures of intra-tumor heterogeneity are associated with worse response to endocrine therapy. To investigate heterogeneity in response to treatment, we developed an operating room-to-laboratory pipeline for the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd165c03100ad0f8ad55e228c7d69e8
https://doi.org/10.1101/2023.04.01.535159
https://doi.org/10.1101/2023.04.01.535159
Male breast cancer represents about 1% of all breast cancer diagnoses and, although there are some similarities between male and female breast cancer, the paucity of data available on male breast cancer makes it difficult to establish targeted therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c024e3ea6dea309d1f85f3ec1402561
https://doi.org/10.1101/2022.12.02.518918
https://doi.org/10.1101/2022.12.02.518918