Zobrazeno 1 - 2
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pro vyhledávání: '"Hector J. Grazio"'
Publikováno v:
Journal of Biological Chemistry. 275:38611-38619
The rod photoreceptor phosphodiesterase (PDE) is unique among all known vertebrate PDE families for several reasons. It is a catalytic heterodimer (alphabeta); it is directly activated by a G-protein, transducin; and its active sites are regulated by
Publikováno v:
Journal of Biological Chemistry. 274:18813-18820
The binding of cGMP to the noncatalytic sites on two isoforms of the phosphodiesterase (PDE) from mammalian rod outer segments has been characterized to evaluate their role in regulating PDE during phototransduction. Nonactivated, membrane-associated