Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hector Herranz"'
Autor:
Casper Groth, Pooja Vaid, Aditi Khatpe, Nelchi Prashali, Avantika Ahiya, Diana Andrejeva, Madhumita Chakladar, Sanket Nagarkar, Rachel Paul, Devaki Kelkar, Teresa Eichenlaub, Hector Herranz, TS Sridhar, Stephen M. Cohen, LS Shashidhara
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 2999-3008 (2020)
Genetic approaches in Drosophila have successfully identified many genes involved in regulation of growth control as well as genetic interactions relevant to the initiation and progression of cancer in vivo. Here, we report on large-scale RNAi-based
Externí odkaz:
https://doaj.org/article/e1fb7176b05c46169a5d8e011d094d80
Autor:
Jiangbo Song, Zhiquan Li, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen, Fangyin Dai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract FOXO transcription factors modulate aging-related pathways and influence longevity in multiple species, but the transcriptional targets that mediate these effects remain largely unknown. Here, we identify an evolutionarily conserved FOXO tar
Externí odkaz:
https://doaj.org/article/6d8e7769443a4b1ca5a7abe0242df507
Autor:
Michael Angelo Petr, Lina M Carmona-Marin, Tulika Tulika, Stella Kristensen, Simon Reves, Daniela Bakula, Guido Keijzers, Brenna Osborne, Sarah J Mitchell, Sam Hamilton, Jonathan Kato, Irene Alfaras, Amanuel A. Teklu, Indra Heckenbach, Jakob Madsen, Michael Ben Ezra, Garik Mkrtchyan, Erika Varner, Benjamin Fink, Eliana von Krusenstiern, Nathaniel W Snyder, Hector Herranz, Rafael de Cabo, Morten Scheibye-Knudsen
SUMMARYThere is currently no established intervention for Cockayne syndrome, a disease characterized by progressive early onset neurodegeneration with features of premature aging. Here, we tested if acetyl-CoA precursors, citrate and beta-hydroxybuty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd60a3aee6463049e9191d2cb534bb5
https://doi.org/10.1101/2022.03.08.483430
https://doi.org/10.1101/2022.03.08.483430
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/2cb31e65c83a422b8a1faa456abac107
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
The regulation of the cell division cycle is governed by a complex network of factors that together ensure that growing or proliferating cells maintain a stable genome. Defects in this system can lead to genomic instability that can affect tissue hom
Externí odkaz:
https://doaj.org/article/7760f61589734a32b5b700f7f3f1ceb4
Autor:
Stephan U. Gerlach, Héctor Herranz
Publikováno v:
Open Biology, Vol 10, Iss 6 (2020)
Cancer is a genetic disease that involves the gradual accumulation of mutations. Human tumours are genetically unstable. However, the current knowledge about the origins and implications of genomic instability in this disease is limited. Understandin
Externí odkaz:
https://doaj.org/article/ffacf5a8cd8b4ce58cb6d1c530ec308d
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1491-1503 (2018)
Summary: Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However,
Externí odkaz:
https://doaj.org/article/d6f7c94b15ff4e1594830401f7d23523
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 10, Pp 1201-1209 (2017)
Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF comp
Externí odkaz:
https://doaj.org/article/f68485a491594b51bf1364f0e6393ce8
Autor:
Héctor Herranz, Stephen M. Cohen
Publikováno v:
Journal of Developmental Biology, Vol 5, Iss 4, p 15 (2017)
Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes c
Externí odkaz:
https://doaj.org/article/b6f935ab53e447308ddb8d5e68653242
Autor:
Javier Buceta, Héctor Herranz, Oriol Canela-Xandri, Ramon Reigada, Francesc Sagués, Marco Milán
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e602 (2007)
Gene regulatory networks have been conserved during evolution. The Drosophila wing and the vertebrate hindbrain share the gene network involved in the establishment of the boundary between dorsal and ventral compartments in the wing and adjacent rhom
Externí odkaz:
https://doaj.org/article/a5735a02347643f9aa0db0b43607b5a2