Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hector Hernández-Vargas"'
Autor:
Diana M. Narváez, Helena Groot, Sonia M. Diaz, Ruth Marien Palma, Nathalia Muñoz, Marie-Pierre Cros, Hector Hernández-Vargas
Publikováno v:
Heliyon, Vol 3, Iss 9 (2017)
Mercury (Hg) exposure is a public health concern due to its persistence in the environment and its high toxicity. Such toxicity has been associated with the generation of oxidative stress in occupationally exposed subjects, such as artisanal gold min
Externí odkaz:
https://doaj.org/article/0afd59ecb34d446e8a4b20a50b2c23e5
Autor:
Anda Huna, Jean-Michel Flaman, Catalina Lodillinsky, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background TGFβ induces several cell phenotypes including senescence, a stable cell cycle arrest accompanied by a secretory program, and epithelial-mesenchymal transition (EMT) in normal epithelial cells. During carcinogenesis cells lose th
Externí odkaz:
https://doaj.org/article/366dc4f5a8974d69aeb31558a29f5fe0
Autor:
Kourosh Kouhmareh, Erika Martin, Darren Finlay, Anukriti Bhadada, Hector Hernandez-Vargas, Francisco Downey, Jeffrey K Allen, Peter Teriete
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0306450 (2024)
Metastasis remains the leading cause of cancer deaths worldwide and lung cancer, known for its highly metastatic progression, remains among the most lethal of malignancies. Lung cancer metastasis can selectively spread to multiple different organs, h
Externí odkaz:
https://doaj.org/article/254d0325e84b4b6bb55f1e57e12fe1ff
Autor:
Alexandra Lainé, Ossama Labiad, Hector Hernandez-Vargas, Sébastien This, Amélien Sanlaville, Sophie Léon, Stéphane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, Julien C. Marie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TGFβ is secreted in an inactive form in the tumor microenvironment. Authors here show that although TGFβ is produced mainly by cancer cells, regulatory T cells are necessary for its activation via expression of the b8 chain of avb8 integrin. Thus,
Externí odkaz:
https://doaj.org/article/0099bf33b303405fa97900689fb2a35e
Autor:
Louciné Mitoyan, Véronique Chevrier, Hector Hernandez-Vargas, Alexane Ollivier, Zeinab Homayed, Julie Pannequin, Flora Poizat, Cécile De Biasi-Cador, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Géraldine Guasch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contrib
Externí odkaz:
https://doaj.org/article/296e414aa37a402286028e30347ff680
Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
Autor:
Chloe Goldsmith, Jesús Rafael Rodríguez-Aguilera, Ines El-Rifai, Adrien Jarretier-Yuste, Valérie Hervieu, Olivier Raineteau, Pierre Saintigny, Victoria Chagoya de Sánchez, Robert Dante, Gabriel Ichim, Hector Hernandez-Vargas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical limitations, it has been less clear if mitochondrial DNA (mtDNA) is methylated and whethe
Externí odkaz:
https://doaj.org/article/4221444650b74227b0be0661a1952aaf
Autor:
Anda Huna, Audrey Griveau, David Vindrieux, Sara Jaber, Jean-Michel Flaman, Delphine Goehrig, Lamia Azzi, Jean-Jacques Médard, Sophia Djebali, Hector Hernandez-Vargas, Robert Dante, Léa Payen, Jacqueline Marvel, Philippe Bertolino, Sébastien Aubert, Pierre Dubus, David Bernard
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-12 (2021)
Abstract Although aging is a major risk factor for most types of cancers, it is barely studied in this context. The transmembrane protein PLA2R1 (phospholipase A2 receptor) promotes cellular senescence, which can inhibit oncogene-induced tumor initia
Externí odkaz:
https://doaj.org/article/5df3bc9b126a40bd9a509fe79c7b7adf
Autor:
Ramdane Igalouzene, Hector Hernandez-Vargas, Nicolas Benech, Alexandre Guyennon, David Bauché, Célia Barrachina, Emeric Dubois, Julien C. Marie, Saïdi M’Homa Soudja
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
SMAD4, a mediator of TGF-β signaling, plays an important role in T cells to prevent inflammatory bowel disease (IBD). However, the precise mechanisms underlying this control remain elusive. Using both genetic and epigenetic approaches, we revealed a
Externí odkaz:
https://doaj.org/article/2886b0a4303f42199a23c95ebdc851af
Autor:
Deborah Fanfone, Zhichong Wu, Jade Mammi, Kevin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, François Virard, Félix Bunel, Catherine Jamard, Hector Hernandez-Vargas, Stephen WG Tait, Ana Hennino, Gabriel Ichim
Publikováno v:
eLife, Vol 11 (2022)
Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are constantly challenged by mechanical stresses not only in the primary tumour but also during me
Externí odkaz:
https://doaj.org/article/f33cdea831cd4345a18c8c0bfc588ea6
Autor:
Iolanda Agliata, Nora Fernandez-Jimenez, Chloe Goldsmith, Julien C. Marie, Jose R. Bilbao, Robert Dante, Hector Hernandez-Vargas
Publikováno v:
Epigenetics, Vol 15, Iss 10, Pp 1068-1082 (2020)
Abnormal DNA methylation has been described in human inflammatory conditions of the gastrointestinal tract, such as inflammatory bowel disease (IBD). As other complex diseases, IBD results from the balance between genetic predisposition and environme
Externí odkaz:
https://doaj.org/article/c9b582c2535140b0b62ca178a3d45177