Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hector H Huang"'
Autor:
Hector H. Huang, Ian D. Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam, Yu-Hsiu T. Lin, Priya Choudhry, Margarette C. Mariano, Makeba D. Marcoulis, Chin Fen Teo, Julia Malato, Paul J. Phojanakong, Thomas G. Martin, Jeffrey L. Wolf, Sandy W. Wong, Nina Shah, Byron Hann, Angela N. Brooks, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins,
Externí odkaz:
https://doaj.org/article/9ede6677994c4ad081bb8e902cda0b7a
Autor:
Jennifer Y. Liu, Yu-Hsiu Tony Lin, Andrew M. Leidal, Hector H. Huang, Jordan Ye, Arun P. Wiita, Jayanta Debnath
Publikováno v:
Biology Open, Vol 10, Iss 10 (2021)
There is great interest in understanding the cellular mechanisms controlling autophagy, a tightly regulated catabolic and stress-response pathway. Prior work has uncovered links between autophagy and the Golgi reassembly stacking protein of 55 kDa (G
Externí odkaz:
https://doaj.org/article/b3ee2488c0e6420994aa9e99271c648f
Autor:
Prasanna Ramachandran, Gege Xu, Hector H. Huang, Rachel Rice, Bo Zhou, Klaus Lindpaintner, Daniel Serie
Publikováno v:
Journal of Proteome Research. 21:1083-1094
Fatty liver disease progresses through stages of fat accumulation and inflammation to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and eventually hepatocellular carcinoma (HCC). Currently available diagnostic tools for HCC lack sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9169433ecccf2101e2080db1d07a0bac
https://doi.org/10.1021/acs.jproteome.1c00965
https://doi.org/10.1021/acs.jproteome.1c00965
Autor:
FuiBoon Kai, Guanqing Ou, Richard W Tourdot, Connor Stashko, Guido Gaietta, Mark F Swift, Niels Volkmann, Alexandra F Long, Yulong Han, Hector H Huang, Jason J Northey, Andrew M Leidal, Virgile Viasnoff, David M Bryant, Wei Guo, Arun P Wiita, Ming Guo, Sophie Dumont, Dorit Hanein, Ravi Radhakrishnan, Valerie M Weaver
Publikováno v:
The EMBO Journal. 41
Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stress resilient tissue p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8521c25b6a5f48ddd107629b61e2a968
https://doi.org/10.15252/embj.2021109205
https://doi.org/10.15252/embj.2021109205
Autor:
Paul Phojanakong, Chin Fen Teo, Alexis M. Thornton, Byron Hann, Nina Shah, Christine Lam, Thomas G. Martin, Jeffrey L. Wolf, Ian Ferguson, Sandy W. Wong, Angela N. Brooks, Prabhakar Bastola, Makeba Marcoulis, Yu-Hsiu T. Lin, Margarette C. Mariano, Arun P. Wiita, Priya Choudhry, Hector H. Huang, Julia Malato
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Enhancing the efficacy of proteasome inhibitors (PI) is a central goal in myeloma therapy. We proposed that signaling-level responses after PI may reveal new mechanisms of action that can be therapeutically exploited. Unbiased phosphoproteomics after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab08cb20defbdefde847c8836b261932
http://link.springer.com/article/10.1038/s41467-020-15521-4
http://link.springer.com/article/10.1038/s41467-020-15521-4
Autor:
Andrew M. Leidal, Yu-Hsiu Tony Lin, Hector H. Huang, Jayanta Debnath, Jordan Ye, Jennifer Y. Liu, Arun P. Wiita
Publikováno v:
Biology Open
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 10 (2021)
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 10 (2021)
There is great interest in understanding the cellular mechanisms controlling autophagy, a tightly regulated catabolic and stress-response pathway. Prior work has uncovered links between autophagy and the Golgi reassembly stacking protein of 55 kDa (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e325958a0f4aa560565deefda84dfe2f
http://europepmc.org/articles/PMC8524720
http://europepmc.org/articles/PMC8524720
Autor:
Hector H. Huang, Ian D. Ferguson, Alexis M. Thornton, Christine Lam, Yu-Hsiu T. Lin, Prabhakar Bastola, Priya Choudhry, Margarette C. Mariano, Makeba Marcoulis, Julia Malato, Paul Phojanakong, Thomas G. Martin, Jeffrey L. Wolf, Sandy W. Wong, Nina Shah, Byron C. Hann, Angela N. Brooks, Arun P. Wiita
Enhancing the efficacy of proteasome inhibitors is a central goal in myeloma therapy. We proposed that signaling-level responses after PI would reveal new mechanisms of action that could be therapeutically exploited. Unbiased phosphoproteomics after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7bac873058871ab3b6bac4e88ffab6
https://doi.org/10.1101/508549
https://doi.org/10.1101/508549
Autor:
Il-Hyung Lee, Hector H. Huang, Anirban Polley, Madan Rao, Satyajit Mayor, Jay T. Groves, Suvrajit Saha
Publikováno v:
The Journal of Physical Chemistry B. 119:4450-4459
Lipid/cholesterol mixtures derived from cell membranes as well as their synthetic reconstitutions exhibit well-defined miscibility phase transitions and critical phenomena near physiological temperatures. This suggests that lipid/cholesterol-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf7cb22121ae3d614c14071a633a067
https://doi.org/10.1021/jp512839q
https://doi.org/10.1021/jp512839q
Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics
Autor:
Tzu-Yu Liu, James A. Wells, Hector H. Huang, Arun P. Wiita, Yun S. Song, Diamond Wheeler, Yichen Xu
Publikováno v:
Cell systems, vol 4, iss 6
Ribosome profiling is a widespread tool for studying translational dynamics in human cells. Its central assumption is that ribosome footprint density on a transcript quantitatively reflects protein synthesis. Here, we test this assumption using pulse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef0b93d9e96c3fee47888e6af579533
https://europepmc.org/articles/PMC5546878/
https://europepmc.org/articles/PMC5546878/
SummaryMany small molecule chemotherapeutics induce stresses that globally inhibit mRNA translation, remodeling the cancer proteome and governing response to treatment. Here we measured protein synthesis in multiple myeloma cells treated with low-dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b92e2b0079e74198328ba417c0cc5c