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pro vyhledávání: '"Hector A. Velazquez"'
Akademický článek
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Autor:
Juan Carlos Méndez Gutiérrez, Luis García-Covarrubias, Arturo Reding-Bernal, Héctor A. Velázquez Chong, Diana F. Fernández Ángel, Aldo García Covarrubias, Juan Carlos Hernández-Rivera
Publikováno v:
Brazilian Journal of Otorhinolaryngology, Vol 90, Iss 2, Pp 101360- (2024)
Objectives: To analyze the clinical utility of a clinical risk scale to predict the need for advanced airway management in patients with deep neck abscess. Methods: Observational, analytical, cross-sectional study. Patients over 18 years old, both ge
Externí odkaz:
https://doaj.org/article/2ec25ca1744041b6a84c07980224aabd
Autor:
Hector A. Velazquez, S. Z. Fisher, Andrey Kovalevsky, Jeremy C. Smith, Robert McKenna, Mayank Aggarwal
Publikováno v:
IUCrJ, Vol 3, Iss 5, Pp 319-325 (2016)
IUCrJ
IUCrJ
The room-temperature X-ray/neutron structure of human carbonic anhydrase II in complex with methazolamide has been determined. The study provides new insights into the hydrogen-bonding changes that take place within the active site of an enzyme upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b764f98a2c1cb36012346d0ded8be2f3
http://scripts.iucr.org/cgi-bin/paper?S2052252516010514
http://scripts.iucr.org/cgi-bin/paper?S2052252516010514
Autor:
Jerome Baudry, Zhousheng Xiao, Hector A. Velazquez, Demian Riccardi, Jeremy C. Smith, Leigh Darryl Quarles, Charless Ryan Yates
Publikováno v:
Chem Biol Drug Des
Ensemble docking is now commonly used in early-stage in silico drug discovery and can be used to attack difficult problems such as finding lead compounds which can disrupt protein-protein interactions. We give an example of this methodology here, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bdb5e7dea8450fd97e5b30fbdf4f03
https://europepmc.org/articles/PMC7983124/
https://europepmc.org/articles/PMC7983124/
Autor:
Donald Hamelberg, Hector A. Velazquez
Publikováno v:
The Journal of Physical Chemistry B. 117:11509-11517
Human peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an essential enzyme in numerous phosphorylation-dependent regulatory pathways and has been implicated in many diseases, including cancer and Alzheimers. Pin1 specifically catalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f0444cd44c38d3a6fbb63266c4695d
https://doi.org/10.1021/jp405271s
https://doi.org/10.1021/jp405271s
Autor:
Jeremy C. Smith, Charles R. Yates, Ai L. Chin, L. Darryl Quarles, Hector A. Velazquez, Jerome Baudry, Zhousheng Xiao, Jesse D. Carrick, Demian Riccardi
Publikováno v:
Science signaling. 9(455)
Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of α-Klotho (α-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney. Excess FGF-23 production, which causes hypophosphatemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7362123b06032b8c971e957ba1ca790
https://pubmed.ncbi.nlm.nih.gov/27923912
https://pubmed.ncbi.nlm.nih.gov/27923912
Autor:
Donald Hamelberg, Hector A. Velazquez
Publikováno v:
Biochemistry. 50:9605-9615
Post-translational phosphorylation and the related conformational changes in signaling proteins are responsible for regulating a wide range of subcellular processes. Human Pin1 is central to many of these cell signaling pathways in normal and aberran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbb6c2c661b905d9f5297fcfac3d9cc
https://doi.org/10.1021/bi2009954
https://doi.org/10.1021/bi2009954
Autor:
Andrey Kovalevsky, Robert McKenna, Kevin L. Weiss, Matthew P. Blakeley, Mayank Aggarwal, Jeremy C. Smith, Matthew J. Cuneo, Hector A. Velazquez, S. Zoë Fisher
Publikováno v:
Structure. 26:383-390.e3
Summary Human carbonic anhydrases (hCAs) play various roles in cells, and have been drug targets for decades. Sequence similarities of hCA isoforms necessitate designing specific inhibitors, which requires detailed structural information for hCA-inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b59ddbc57b3f6b3c4f603e2054a1dc
https://doi.org/10.1016/j.str.2018.01.006
https://doi.org/10.1016/j.str.2018.01.006
Publikováno v:
International Journal of Mass Spectrometry. 265:213-223
Gas-phase acidities (GA or ΔGacid) for the two most acidic common amino acids, aspartic acid and glutamic acid, have been determined for the first time. Because of the amide linkage's importance in peptides and as an aid in studying side chain versu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c3eaf9b1889a1a91105db7f9d06d200
https://doi.org/10.1016/j.ijms.2007.02.009
https://doi.org/10.1016/j.ijms.2007.02.009
Autor:
Donald Hamelberg, Hector A. Velazquez
Publikováno v:
The Journal of chemical physics. 142(7)
Cis-trans isomerization of peptidyl-prolyl bonds of the protein backbone plays an important role in numerous biological processes. Cis-trans isomerization can be the rate-limiting step due its extremely slow dynamics, compared to the millisecond time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa0fd5f029e98fb9620b80dc262187b
https://pubmed.ncbi.nlm.nih.gov/25702031
https://pubmed.ncbi.nlm.nih.gov/25702031