Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Hector A. Moreno"'
Publikováno v:
Symmetry, Vol 15, Iss 11, p 2071 (2023)
Mobile robotics has been used in recent years to provide various types of services in fields such as agriculture, surveillance, rehabilitation, space exploration, and logistics, among others. In many cases, mobile robots need to overcome complex obst
Externí odkaz:
https://doaj.org/article/86d70d5527b44e718b331f845a723e20
Autor:
Andrew F. Maule, Jenyne Loarca, Luis Diaz-Garcia, Hector Lopez-Moreno, Jennifer Johnson-Cicalese, Nicholi Vorsa, Massimo Iorizzo, Jeffrey L. Neyhart, Juan E. Zalapa
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
IntroductionFor nearly two centuries, cranberry (Vaccinium macrocarpon Ait.) breeders have improved fruit quality and yield by selecting traits on fruiting stems, termed “reproductive uprights.” Crop improvement is accelerating rapidly in contemp
Externí odkaz:
https://doaj.org/article/cac2705f0b434276ab232ec31440d3e5
Autor:
Shadman H. Khan, Sourav Kumar Sahoo, Ismael Himar Falcon-Suarez, Hector Marin-Moreno, Hanif Sutiyoso, B. N. Madhusudhan, C. B. Majumder, Amit Arora, Angus I. Best
Publikováno v:
Frontiers in Earth Science, Vol 12 (2024)
We present a time-lapse 4-D high-resolution synchrotron imaging study of the morphological evolution of methane gas bubbles and hydrate film growth on these bubbles. Methane gas and partially water-saturated sand were used to form hydrate with a maxi
Externí odkaz:
https://doaj.org/article/4eb4d08a16a84714962f14063922434d
Autor:
Mafalda Raposo, Jeannette Hübener-Schmid, Rebecca Tagett, Ana F. Ferreira, Ana Rosa Vieira Melo, João Vasconcelos, Paula Pires, Teresa Kay, Hector Garcia-Moreno, Paola Giunti, Magda M. Santana, Luis Pereira de Almeida, Jon Infante, Bart P. van de Warrenburg, Jeroen J. de Vries, Jennifer Faber, Thomas Klockgether, Nicolas Casadei, Jakob Admard, Ludger Schöls, Olaf Riess, Maria do Carmo Costa, Manuela Lima
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106456- (2024)
Spinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) is a heritable proteinopathy disorder, whose causative gene, ATXN3, undergoes alternative splicing. Ataxin-3 protein isoforms differ in their toxicity, suggesting that certain ATXN3 sp
Externí odkaz:
https://doaj.org/article/55040c47afa6470abe2d27e0791d4080
Autor:
Direnis Erdinc, Alejandro Rodríguez‐Luis, Mahmoud R Fassad, Sarah Mackenzie, Christopher M Watson, Sebastian Valenzuela, Xie Xie, Katja E Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Genomics England Research Consortium, Joanna Poulton, Hector Garcia‐Moreno, Paola Giunti, Carlos A de Moura Aschoff, Jonas A Morales Saute, Amelia J Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Gráinne S Gorman, Andrew M Schaefer, Claes M Gustafsson, Robert W Taylor, Maria Falkenberg, Thomas J Nicholls
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp 1-21 (2023)
Abstract Topoisomerase 3α (TOP3A) is an enzyme that removes torsional strain and interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria, with the two isoforms playing specialised roles in DNA recombination and replica
Externí odkaz:
https://doaj.org/article/c9e7e4ced0784d4394725c67d2a116f4
Autor:
Nazgol Motamed-Gorji, Youssef Khalil, Cristina Gonzalez-Robles, Shamsher Khan, Philippa Mills, Hector Garcia-Moreno, Heather Ging, Ambreen Tariq, Peter T. Clayton, Paola Giunti
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 561 (2024)
Ataxia is a common neurological feature of Niemann–Pick disease type C (NPC). In this disease, unesterified cholesterol accumulates in lysosomes of the central nervous system and hepatic cells. Oxidation by reactive oxygen species produces oxystero
Externí odkaz:
https://doaj.org/article/0efdb0f636d045a4a21de458aecaca0b
Autor:
Gilbert Thomas-Black, Andrada Dumitrascu, Hector Garcia-Moreno, Julie Vallortigara, Julie Greenfield, Barry Hunt, Susan Walther, Mackenzie Wells, David R. Lynch, Hugh Montgomery, Paola Giunti
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-10 (2022)
Abstract Background The development of new therapies may rely on the conduct of human experimentation as well as later clinical trials of therapeutic interventions. Ethical considerations seek to protect the patient from risk but few have sought to a
Externí odkaz:
https://doaj.org/article/7cdfe06b3261409aa3b0c3ebccaa3625
Autor:
Carlo Wilke, Eva Haas, Kathrin Reetz, Jennifer Faber, Hector Garcia‐Moreno, Magda M Santana, Bart van de Warrenburg, Holger Hengel, Manuela Lima, Alessandro Filla, Alexandra Durr, Bela Melegh, Marcella Masciullo, Jon Infante, Paola Giunti, Manuela Neumann, Jeroen de Vries, Luis Pereira de Almeida, Maria Rakowicz, Heike Jacobi, Rebecca Schüle, Stephan A Kaeser, Jens Kuhle, Thomas Klockgether, Ludger Schöls, SCA3 neurofilament study group, Christian Barro, Jeannette Hübener‐Schmid, Matthis Synofzik, Christian Deuschle, Elke Stransky, Kathrin Brockmann, Jörg B Schulz, Laszlo Baliko, Judith van Gaalen, Mafalda Raposo, Andreas Jeromin
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-19 (2020)
Abstract With molecular treatments coming into reach for spinocerebellar ataxia type 3 (SCA3), easily accessible, cross‐species validated biomarkers for human and preclinical trials are warranted, particularly for the preataxic disease stage. We as
Externí odkaz:
https://doaj.org/article/5f400354b7714009b295040d28db33a6
Autor:
Alexander F. Brown, Michael H. Parkinson, Hector Garcia-Moreno, Ese Mudanohwo, Robyn Labrum, Mary Sweeney, Paola Giunti
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Patients with suspected genetic ataxia are often tested for Friedreich's ataxia (FRDA) and/or a variety of spinocerebellar ataxias (SCAs). FRDA can present with atypical, late-onset forms and so may be missed in the diagnostic process. We
Externí odkaz:
https://doaj.org/article/a50342b364bf44d59646d07ac96bd074
Autor:
Daniela Scarabino, Liana Veneziano, Alessia Fiore, Suran Nethisinghe, Elide Mantuano, Hector Garcia-Moreno, Gianmarco Bellucci, Nita Solanky, Maria Morello, Ginevra Zanni, Rosa Maria Corbo, Paola Giunti
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1436 (2022)
SCA1, SCA2, and SCA3 are the most common forms of SCAs among the polyglutamine disorders, which include Huntington’s Disease (HD). We investigated the relationship between leukocyte telomere length (LTL) and the phenotype of SCA1, SCA2, and SCA3, c
Externí odkaz:
https://doaj.org/article/634eb281641e4a14b5d766d9359f650e