The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling.

Autor: Yi-Shan Chen, Robert J Bastidas, Hector A Saka, Victoria K Carpenter, Kristian L Richards, Gregory V Plano, Raphael H Valdivia

Publikováno v: PLoS Pathogens, Vol 10, Iss 2, p e1003954 (2014)

Chlamydia trachomatis, the causative agent of trachoma and sexually transmitted infections, employs a type III secretion (T3S) system to deliver effector proteins into host epithelial cells to establish a replicative vacuole. Aside from the phosphopr

Externí odkaz: https://doaj.org/article/b2a098f21faf420c86ab2cf2ce755593

IRG and GBP host resistance factors target aberrant, 'non-self' vacuoles characterized by the missing of 'self' IRGM proteins.

Autor: Arun K Haldar, Hector A Saka, Anthony S Piro, Joe Dan Dunn, Stanley C Henry, Gregory A Taylor, Eva M Frickel, Raphael H Valdivia, Jörn Coers

Publikováno v: PLoS Pathogens, Vol 9, Iss 6, p e1003414 (2013)

Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic microbes. IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit

Externí odkaz: https://doaj.org/article/d850e28d862a44b7a4c21959a7baf791

Editorial: New insights in Chlamydia: host interactions and pathogenesis

Autor: Hector Alex Saka, Maria Teresa Damiani

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Externí odkaz: https://doaj.org/article/f3d4ff2c2f954134a3bdcfd2b7c3a894

Caracterización clínica, epidemiológica y microbiológica de bacteriemias producidas por enterobacterias resistentes a carbapenems en un hospital universitario de Córdoba, Argentina

Autor: Juan Pablo Caeiro, Daniela Hernández, Hector Alex Saka, Flavio Gabriel Lipari, Mario Vilaró

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Revista chilena de infectología v.37 n.4 2020
SciELO Chile
CONICYT Chile
instacron:CONICYT

Enterobacteriaceae are a major cause of bloodstream infections and their antimicrobial resistance continues to increase. This leads to higher morbidity-mortality rates and public health costs. Carbapenem-resistant Enterobacteriaceae represent a serio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de74385736d231e1958cd55851ad5abc
https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182020000400362&lng=en&nrm=iso&tlng=en

Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo

Autor: Raphael H. Valdivia, Maria Emilia Panzetta, Hector Alex Saka

Publikováno v: Frontiers in Microbiology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Microbiology, Vol 9 (2018)

The Chlamydiaceae comprise a group of highly adapted bacterial pathogens sharing a unique intracellular lifestyle. Three Chlamydia species are pathogenic to humans: Chlamydia trachomatis, Chlamydia pneumoniae, and Chlamydia psittaci. C. trachomatis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416f81b6c1e0d81a598eea3ede942705
http://europepmc.org/articles/PMC6299033