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Programmed Death-Ligand 1 (PD-L1) Expression Is Induced by Insulin in Pancreatic Ductal Adenocarcinoma Cells Pointing to Its Role in Immune Checkpoint Control

Autor: Heckl, Steffen M., Mau, Franziska, Senftleben, Anke, Daunke, Tina, Beckinger, Silje, Abdullazade, Samir, Schreiber, Stefan, Röcken, Christoph, Sebens, Susanne, Schäfer, Heiner

Publikováno v: Medical Sciences, Vol 9, Iss 48, p 48 (2021)
Medical Sciences
Volume 9
Issue 3

Simple Summary Type-2 Diabetes is an established risk factor of pancreatic cancer, yet the exact modalities as well as the contribution of hyperinsulinemia are not fully understood. In our study, we explored a possible link between insulin and the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b5d148a97ebc90edf92631e93bbf15e8
https://www.mdpi.com/2076-3271/9/3/48

Epithelial insulin receptor expression-prognostic relevance in colorectal cancer.

Autor: Heckl SM; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany., Pellinghaus M; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany., Krüger S; Department of Pathology, Christian-Albrechts-University, Kiel, Germany., Bosselmann C; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany., Wilhelm F; Department of Pathology, Christian-Albrechts-University, Kiel, Germany., Behrens HM; Department of Pathology, Christian-Albrechts-University, Kiel, Germany., Schreiber S; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany., Röcken C; Department of Pathology, Christian-Albrechts-University, Kiel, Germany.

Publikováno v: Oncotarget [Oncotarget] 2018 Dec 25; Vol. 9 (101), pp. 37497-37508. Date of Electronic Publication: 2018 Dec 25 (Print Publication: 2018).