Výsledky vyhledávání - "Heba S. Abed"

Evaluation of the combined effects of pegylation and glycosylation on the stability of erythropoietin using a stability-indicating SE-HPLC

Autor: Faten A. Fathalla, Medhat A. Al-Ghobashy, Heba S. Abed, Maissa Y. Salem

Publikováno v: Biologicals. 50:129-136

Recombinant human erythropoietin (rhEPO) is a commonly used biopharmaceutical for the treatment of anemia-associated disorders. Epogen; glycosylated erythropoietin (G-EPO) has short half-life and poor stability. Pegylated Epogen (Peg-G-EPO) was intro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c7b128217e76b486d406cbb3035b1e
https://doi.org/10.1016/j.biologicals.2017.08.012

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Correlation between Dynamic Light Scattering and Size Exclusion High Performance Liquid Chromatography for Monitoring the Effect of pH on Stability of Biopharmaceuticals

Autor: Faten A. Fathalla, Maissa Y. Salem, Medhat A. Al-Ghobashy, Moushira M. Mostafa, Heba S. Abed

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1060

Aggregate formation is a major problem affecting both safety and efficacy of biopharmaceuticals and is associated with protein immunogenicity. Size exclusion high performance liquid chromatography (SE-HPLC) has always been the gold standard technique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98635a0ad4f135474bbb7b4be67836b
https://pubmed.ncbi.nlm.nih.gov/28578190

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