Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Heba M. Abo-Salem"'
1
Akademický článek
Anti colorectal cancer activity and in silico studies of novel pyridine nortopsentin analog as cyclin dependent kinase 6 inhibitor
Autor: Heba Abdelmegeed, Heba M. Abo-Salem, Ehab M. Zayed, Eslam R. El-Sawy
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Nortopsentins are a vital class of deep-sea sponge metabolites which can be used as leads for antitumor agents. Although their action has been studied in several diseases’ contexts, their cytotoxic activity against colorectal carcinoma has
Externí odkaz: https://doaj.org/article/a17545607e19480182618fc532f24f18
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2
Akademický článek
Synthesis, bioactivity assessment, molecular docking and ADMET studies of new chromone congeners exhibiting potent anticancer activity
Autor: Heba M. Abo-Salem, Sahar S. M. El Souda, Heba I. Shafey, Khairy M. A. Zoheir, Khadiga M. Ahmed, Kh. Mahmoud, Karima F. Mahrous, Nagwa M. Fawzy
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)
Abstract In consideration of the chromones' therapeutic potential and anticancer activity, a new series of chromanone derivatives have been synthesized through a straightforward reaction between 6-formyl-7-hydroxy-5-methoxy-2-methylchromone (2) and v
Externí odkaz: https://doaj.org/article/27809bcf930940b8a8a8b071cc3f25dd
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3
Akademický článek
Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors
Autor: Mohammed Abdalla Hussein, Rita M. Borik, Mohamed S. Nafie, Heba M. Abo-Salem, Sylvia A. Boshra, Zahraa N. Mohamed
Publikováno v: Molecules, Vol 28, Iss 16, p 6052 (2023)
The current work was conducted to synthesize several novel anti-inflammatory quinazolines having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors. The thioureido derivative 3 was formed when compound 2 was treated with sulfamerazine.
Externí odkaz: https://doaj.org/article/f8463908097e40f680939308612b4ebc
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5
Akademický článek
Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of Bis(Indolyl)Pyridines Analogues of the Marine Alkaloid Nortopsentin
Autor: Heba M. Abo-Salem, Hayam A. Abd El Salam, Anhar Abdel-Aziem, Mohamed S. Abdel-Aziz, Eslam Reda El-Sawy
Publikováno v: Molecules, Vol 26, Iss 14, p 4112 (2021)
An efficient and simple protocol for the synthesis of a new class of diverse bis(indolyl)pyridines analogues of the marine alkaloid nortopsentin has been reported. A one-pot four-component condensation of 3-cyanocarbomethylindole, various aldehyde, 3
Externí odkaz: https://doaj.org/article/4b1ce2d83e6e4ca39fccf8039bfdb2db
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6
Akademický článek
Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective in vitro Anticancer Effects
Autor: Heba M. Abo-Salem, Amr Nassrallah, Ahmed A.F. Soliman, Manal S. Ebied, Mohamed E. Elawady, Sayeda A. Abdelhamid, Eslam R. El-Sawy, Yazeed A. Al-Sheikh, Mourad A. M. Aboul-Soud
Publikováno v: Molecules, Vol 25, Iss 5, p 1124 (2020)
The present work aims to design and synthesize novel series of spiro pyrazole-3,3’-oxindoles analogues and investigate their bioactivity as antioxidant and antimicrobial agents, as well as antiproliferative potency against selected human cancerous
Externí odkaz: https://doaj.org/article/3d8b7f5c955d4f22b8e3cd1b5e905c41
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7
Akademický článek
Synthesis and biological activity of novel series of 4-methoxy, and 4,9-dimethoxy-5-substituted furo[2,3-g]-1,2,3-benzoxathiazine-7,7-dioxide derivatives
Autor: Eslam R. El-Sawy, Manal S. Ebaid, Heba M. Abo-Salem, Salwa El-Hallouty, Emad M. Kassem, Adel H. Mandour
Publikováno v: Journal of Advanced Research, Vol 5, Iss 3, Pp 337-346 (2014)
A novel series of 4-methoxy, and 4,9-dimethoxy-5-substituted furo[2,3-g]-1,2,3-benzoxathiazine-7,7-dioxide derivatives 3a,b, 10a–g and 11a–g were prepared in good yields via the reaction of 4-methoxy (1a) and 4,7-dimethoxy-5-acetyl-6-hydroxybenzo
Externí odkaz: https://doaj.org/article/ff1003bb87f44230b80919e37ae64c7d
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8
Chitosan Schiff base electrospun fabrication and molecular docking assessment for nonleaching antibacterial nanocomposite production
Autor: Eman AboBakr Ali, Heba M. Abo-Salem, Amany A. Arafa, Ahmed A. Nada
Publikováno v: Cellulose. 30:3505-3522
In this work, new chitosan derivative nanofibers that exhibit antibacterial properties were successfully fabricated. The two CS Schiff base derivatives (CS-APC and CS-2APC) were prepared by incorporating 4-amino antipyrine moiety in two different rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f9d99d9b861404e8c4cb8912e8b1910
https://doi.org/10.1007/s10570-023-05124-9
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9
Pulmonary Phospholipid Components as Promising Natural Inhibitors against COVID-19 Mpro; Molecular Docking Analysis Based Study
Autor: Mohammed A. Hussein, Heba M. Abo-Salem, Ahmed M. Moro, Ebtsam A. Abdel-Wahab, Ali A Ali, Shaimaa A. Abdelkawy
Publikováno v: Asian Journal of Chemistry. 34:2191-2197
The ongoing pandemic of COVID-19 caused by the severe acute respiratory syndrome SARS-CoV-2 has become a global crisis. Phospholipids are structural components of mammalian cell membranes that suppress viral attachment to the plasma membrane and subs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bb261775338fe024cfec3ef300f4a51
https://doi.org/10.14233/ajchem.2022.23691
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