Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heba Ghozlan"'
Autor:
Daniel Nierenberg, Orielyz Flores, David Fox, Yuen Yee Li Sip, Caroline Finn, Heba Ghozlan, Amanda Cox, K. Kai McKinstry, Lei Zhai, Annette R. Khaled
Publikováno v:
ACS Omega, Vol 6, Iss 8, Pp 5591-5606 (2021)
Externí odkaz:
https://doaj.org/article/35acfb6f98cf4aacb5ca982787442537
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Maintenance of the cellular proteome or proteostasis is an essential process that when deregulated leads to diseases like neurological disorders and cancer. Central to proteostasis are the molecular chaperones that fold proteins into functional 3-dim
Externí odkaz:
https://doaj.org/article/52288da60eef492cbd50815caba58ac6
Autor:
Amanda Cox, Ana Martini, Heba Ghozlan, Rebecca Moroose, Xiang Zhu, Eunkyung Lee, Amr S Khaled, Louis Barr, Carlos Alemany, Na'im Fanaian, Elizabeth Griffith, Ryan Sause, S A Litherland, Annette R Khaled
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0264651 (2022)
Herein we report the use of Chaperonin-Containing TCP-1 (CCT or TRiC) as a marker to detect circulating tumor cells (CTCs) that are shed from tumors during oncogenesis. Most detection methods used in liquid biopsy approaches for enumeration of CTCs f
Externí odkaz:
https://doaj.org/article/dc1dd0aa85834c73b0b242631d9dba77
Autor:
Daniel Nierenberg, Orielyz Flores, David Fox, Yuen Yee Li Sip, Caroline M. Finn, Heba Ghozlan, Amanda Cox, Melanie Coathup, Karl Kai McKinstry, Lei Zhai, Annette R. Khaled
Publikováno v:
Biomimetics, Vol 7, Iss 4, p 219 (2022)
Optimizing the biological identity of nanoparticles (NPs) for efficient tumor uptake remains challenging. The controlled formation of a protein corona on NPs through protein absorption from biofluids could favor a biological identity that enables tum
Externí odkaz:
https://doaj.org/article/14948fc2c5f841329c43e0ba2b9cbce6
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Uncontrolled proliferation as a result of dysregulated cell cycling is one of the hallmarks of cancer. Therapeutically targeting pathways that control the cell cycle would improve patient outcomes. However, the development of drug resistance and a li
Externí odkaz:
https://doaj.org/article/f89bf346212a4bac85efd5b5fd299707
Autor:
Annette R. Khaled, James Velazquez, Lam Truong, Colten Frank, Carolyn Dang, Amanda Cox, Heba Ghozlan, Eunkyung Lee, Amr S. Khaled, Priya K. Gopalan
Publikováno v:
Cancer Research. 83:2463-2463
Protein folding complexes are a vital link between the expression of tumor-promoting oncogenes and oncogenic cancer behavior known as the hallmarks of cancer. Of these, the eukaryotic type II chaperonin, Chaperonin-Containing TCP-1 (CCT or TRiC) fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67130094438b56960b12d17904a477c
https://doi.org/10.1158/1538-7445.am2023-2463
https://doi.org/10.1158/1538-7445.am2023-2463
Autor:
Annette R. Khaled, Orielyz Flores, Amanda J. Cox, Heba Ghozlan, K. Kai McKinstry, Caroline Finn, Lei Zhai, Yuen Yee Li Sip, David Fox, Daniel Nierenberg
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 8, Pp 5591-5606 (2021)
ACS Omega, Vol 6, Iss 8, Pp 5591-5606 (2021)
Nanoparticle-mediated cancer drug delivery remains an inefficient process. The protein corona formed on nanoparticles (NPs) controls their biological identity and, if optimized, could enhance cancer cell uptake. In this study, a hyperbranched polyest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d8f2453e2e0f7a1f8c729798a6a473
https://doi.org/10.1021/acsomega.0c05998
https://doi.org/10.1021/acsomega.0c05998
Autor:
Amanda Cox, Ana Martini, Heba Ghozlan, Rebecca Moroose, Xiang Zhu, Eunkyung Lee, Amr S. Khaled, Louis Barr, Carlos Alemany, Na’im Fanaian, Elizabeth Griffith, Ryan Sause, S. A. Litherland, Annette R. Khaled
Publikováno v:
PloS one. 17(6)
Herein we report the use of Chaperonin-Containing TCP-1 (CCT or TRiC) as a marker to detect circulating tumor cells (CTCs) that are shed from tumors during oncogenesis. Most detection methods used in liquid biopsy approaches for enumeration of CTCs f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf95ed3957192e4d69ff4aeba252b1
https://pubmed.ncbi.nlm.nih.gov/35749519
https://pubmed.ncbi.nlm.nih.gov/35749519
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Frontiers in Oncology
Uncontrolled proliferation as a result of dysregulated cell cycling is one of the hallmarks of cancer. Therapeutically targeting pathways that control the cell cycle would improve patient outcomes. However, the development of drug resistance and a li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44e452659e5bdb8ae395dd1da7ac073
https://www.frontiersin.org/articles/10.3389/fonc.2021.663877/full
https://www.frontiersin.org/articles/10.3389/fonc.2021.663877/full
Publikováno v:
Cancer Research. 81:1967-1967
CCT is a protein folding complex that interacts with known oncoproteins, but its role as a driver of oncogenesis is unknown. Elucidating interactions of CCT with cell cycle regulators could reveal the oncogenic potential of the chaperonin. CCT is mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be542e39a33113361aac79afe2d842c5
https://doi.org/10.1158/1538-7445.am2021-1967
https://doi.org/10.1158/1538-7445.am2021-1967