Genomic and clinical predictors of lacosamide response in refractory epilepsies

Autor: Heavin, Sinéad B., McCormack, Mark, Wolking, Stefan, Slattery, Lisa, Walley, Nicole, Avbersek, Andreja, Novy, Jan, Sinha, Saurabh R., Radtke, Rod, Doherty, Colin, Auce, Pauls, Craig, John, Johnson, Michael R., Koeleman, Bobby P. C., Krause, Roland, Kunz, Wolfram S., Marson, Anthony G., O'Brien, Terence J., Sander, Josemir W., Sills, Graeme J., Stefansson, Hreinn, Striano, Pasquale, Zara, Federico, EPIGEN Consortium, EpiPGX Consortium, Depondt, Chantal, Sisodiya, Sanjay, Goldstein, David, Lerche, Holger, Cavalleri, Gianpiero L., Delanty, Norman

Publikováno v: Epilepsia open, vol. 4, no. 4, pp. 563-571
Epilepsia Open, 0(0). (2019).
Epilepsia Open, Vol 4, Iss 4, Pp 563-571 (2019)
Epilepsia Open
Epilepsia Open, 4(4), 563. Wiley-Blackwell Publishing Ltd

Objective: Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting. Methods: We tested the association of clinical predictors with t

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https://serval.unil.ch/resource/serval:BIB_E8A0DD5EBEC6.P001/REF.pdf

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Genomic and clinical predictors of lacosamide response in refractory epilepsies.

Autor: Heavin SB; School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland., McCormack M; School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland.; Luxembourg Centre for Systems Biomedicine University of Luxembourg Esch-sur-Alzette Luxembourg., Wolking S; Department of Neurology and Epileptology Hertie Institute for Clinical Brain Research University of Tübingen Tübingen Germany., Slattery L; School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland., Walley N; Centre for Human Genome Variation Duke University Durham NC USA., Avbersek A; Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK.; Chalfont Centre for Epilepsy Buckinghamshire UK., Novy J; Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK.; Chalfont Centre for Epilepsy Buckinghamshire UK., Sinha SR; Centre for Human Genome Variation Duke University Durham NC USA., Radtke R; Centre for Human Genome Variation Duke University Durham NC USA., Doherty C; School of Medicine Trinity College Dublin Dublin Ireland.; Department of Neurology St James's Hospital Dublin Ireland., Auce P; Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK., Craig J; Department of Neurosciences Belfast Health and Social Care Trust Belfast UK., Johnson MR; Division of Brain Sciences Imperial College Faculty of Medicine London UK., Koeleman BPC; Center of Molecular Medicine University Medical Center Utrecht Utrecht The Netherlands., Krause R; Luxembourg Centre for Systems Biomedicine University of Luxembourg Esch-sur-Alzette Luxembourg., Kunz WS; Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University of Bonn Bonn Germany., Marson AG; Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK., O'Brien TJ; The Departments of Neuroscience and Neurology The Alfred Hospital Monash University Victoria Australia., Sander JW; Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK.; Chalfont Centre for Epilepsy Buckinghamshire UK.; Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands., Sills GJ; Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK., Stefansson H; deCODE Genetics/Amgen Inc Reykjavik Iceland., Striano P; Pediatric Neurology and Muscular Diseases Unit DINOGMI-Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Institute 'G. Gaslini' University of Genova Genova Italy., Zara F; Laboratory of Neurogenetics and Neuroscience Institute G. Gaslini Genova Italy., Depondt C; Department of Neurology Hôpital Erasme Université Libre de Bruxelles Brussels Belgium., Sisodiya S; Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK.; Chalfont Centre for Epilepsy Buckinghamshire UK., Goldstein D; Institute for Genomic Medicine Columbia University New York NY USA., Lerche H; Department of Neurology and Epileptology Hertie Institute for Clinical Brain Research University of Tübingen Tübingen Germany., Cavalleri GL; School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland.; Division of Brain Sciences Imperial College Faculty of Medicine London UK., Delanty N; School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland.; The FutureNeuro SFI Research Centre Royal College of Surgeons in Ireland Dublin Ireland.; Division of Neurology Beaumont Hospital Dublin Ireland.

Publikováno v: Epilepsia open [Epilepsia Open] 2019 Sep 25; Vol. 4 (4), pp. 563-571. Date of Electronic Publication: 2019 Sep 25 (Print Publication: 2019).