Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Heather Tillman"'
Autor:
Lindsay Jones Talbot, Ashley Chabot, Amy Funk, Phuong Nguyen, Jessica Wagner, Aaron Ross, Heather Tillman, Andrew Davidoff, Stephen Gottschalk, Christopher DeRenzo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The outcome for metastatic pediatric osteosarcoma (OS) remains poor. Thus, there is an urgent need to develop novel therapies, and immunotherapy with CAR T cells has the potential to meet this challenge. However, there is a lack of preclinical models
Externí odkaz:
https://doaj.org/article/ced770436fb748028e4dab2bed3ec06b
Autor:
Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf, David Finkelstein, Geoffrey Neale, Eda Machado, Rosario Mosca, Yvan Campos, Heather Tillman, Martine F. Roussel, Jason Andrew Weesner, Leigh Ellen Fremuth, Xiaohui Qiu, Min-Joon Han, Gerard C. Grosveld, Alessandra d’Azzo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by
Externí odkaz:
https://doaj.org/article/642d6aea132848be83c0cf12d1e5c471
Autor:
Shivendra Singh, Ahmed Abu-Zaid, Wenwei Lin, Jonathan Low, Alireza Abdolvahabi, Hongjian Jin, Qiong Wu, Bailey Cooke, Jie Fang, John Bowling, Sivaraja Vaithiyalingam, Duane Currier, Mi-Kyung Yun, Dinesh M. Fernando, Julie Maier, Heather Tillman, Purva Bulsara, Zhaohua Lu, Sourav Das, Anang Shelat, Zhenmei Li, Brandon Young, Richard Lee, Zoran Rankovic, Andrew J. Murphy, Stephen W. White, Andrew M. Davidoff, Taosheng Chen, Jun Yang
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101996- (2021)
Summary: Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with
Externí odkaz:
https://doaj.org/article/06c582be98bb44abbf752e112dc13534
Autor:
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 159 (2022)
Interest in the structure, function, and evolutionary relations of circulating and intracellular globins dates back more than 60 years to the first determination of the three-dimensional structure of these proteins. Non-erythrocytic globins have been
Externí odkaz:
https://doaj.org/article/7342d090c6d2456abfab3e5b28021b3b
Autor:
Yvona Ward, Ross Lake, Farhoud Faraji, Jamie Sperger, Philip Martin, Cameron Gilliard, Kimberly P. Ku, Tamara Rodems, David Niles, Heather Tillman, JuanJuan Yin, Kent Hunter, Adam G. Sowalsky, Joshua Lang, Kathleen Kelly
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 808-822 (2018)
Summary: Tumor cells initiate platelet activation leading to the secretion of bioactive molecules, which promote metastasis. Platelet receptors on tumors have not been well-characterized, resulting in a critical gap in knowledge concerning platelet-p
Externí odkaz:
https://doaj.org/article/1fabd7efcb354c6caf48359b54284e84
Autor:
Stephen Gottschalk, Giedre Krenciute, Heather Tillman, Shondra M. Pruett-Miller, Shaina N. Porter, Jinghui Zhang, Deanna Langfitt, Alejandro Allo Anido, Timothy I. Shaw, Elizabeth Wickman, Jessica Wagner
Supplementary Figures 11-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06511e0197d3fe464aa58e26157b9748
https://doi.org/10.1158/2326-6066.22543755
https://doi.org/10.1158/2326-6066.22543755
Autor:
Stephen Gottschalk, Giedre Krenciute, Heather Tillman, Shondra M. Pruett-Miller, Shaina N. Porter, Jinghui Zhang, Deanna Langfitt, Alejandro Allo Anido, Timothy I. Shaw, Elizabeth Wickman, Jessica Wagner
Chimeric antigen receptor (CAR) T-cell therapy has had limited success in early-phase clinical studies for solid tumors. Lack of efficacy is most likely multifactorial, including a limited array of targetable antigens. We reasoned that targeting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa6c137e1bf563b38b7fdce7fae87d2
https://doi.org/10.1158/2326-6066.c.6550398
https://doi.org/10.1158/2326-6066.c.6550398
Autor:
Scott E. Snyder, Barry L. Shulkin, Yuanyuan Han, Amy L. Vāvere, Shana V. Stoddard, Alan B. Packard, Jason L.J. Dearling, Armita Bahrami, Jieun Kim, Jitendra K. Mishra, Elizabeth Stewart, Heather Tillman, Victor Amador Diaz, Paul E. Mead, Elizabeth R. Butch
The cell membrane glycolipid GD2 is expressed by multiple solid tumors, including 88% of osteosarcomas and 98% of neuroblastomas. However, osteosarcomas are highly heterogeneous, with many tumors exhibiting GD2 expression on 64Cu]Cu-Bn-NOTA-hu14.18K3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c691788cdb0ca4cb75bdc5df01132e4b
https://doi.org/10.1158/0008-5472.c.6510882.v1
https://doi.org/10.1158/0008-5472.c.6510882.v1
Autor:
Scott E. Snyder, Barry L. Shulkin, Yuanyuan Han, Amy L. Vāvere, Shana V. Stoddard, Alan B. Packard, Jason L.J. Dearling, Armita Bahrami, Jieun Kim, Jitendra K. Mishra, Elizabeth Stewart, Heather Tillman, Victor Amador Diaz, Paul E. Mead, Elizabeth R. Butch
Combined Supplementary Data file containing: Figure S1-Detailed ex vivo biodistribution data for three additional PDX tumors. Only summary data included in the manuscript Table 1. Figure S2-Multimodality imaging protocol. Figure S3-Ex vivo biodistrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8271733131230e0cd0bc92cfbc9d205
https://doi.org/10.1158/0008-5472.22421295
https://doi.org/10.1158/0008-5472.22421295
Autor:
Kathleen Kelly, Robert Vessella, Colm Morrissey, Eva Corey, Ross Lake, Lei Fang, Kris Ylaya, Stephen Hewitt, Ben Barrett, Heather Tillman, Yen-Nien Liu, JuanJuan Yin
Supplemental Figure 1.(A) In vitro growth assay for DU145/RasB1 and DU145/RasB1Fn14shRNA cell lines. (B) Average body weight of mice bearing DU145/RasB1 tumors (n= 9mice) or DU145/RasB1Fn14shRNA tumors over time after tumor cell inoculation (shRNA1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b4806bd3832de5573a2944679f814a
https://doi.org/10.1158/0008-5472.22401308
https://doi.org/10.1158/0008-5472.22401308