Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Heather Skor"'
Autor:
Haig Bozigian, Gordon Loewen, Evan Smith, Dimitri E. Grigoriadis, Christopher F. O'Brien, Heather Skor
Publikováno v:
Drugs in R&D
Background Tetrabenazine (TBZ) activity is thought to result from four isomeric dihydrotetrabenazine (HTBZ) metabolites ([+]-α-HTBZ, [−]-α-HTBZ, [+]-β-HTBZ, [−]-β-HTBZ). Each isomer has a unique profile of vesicular monoamine transporter 2 (V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845369d5bd4fa809b25b75656d161a5e
http://europepmc.org/articles/PMC5629142
http://europepmc.org/articles/PMC5629142
Autor:
Ravi Visswanathan, Heather Skor
Publikováno v:
Eliminating Bottlenecks for Efficient Bioanalysis: Practices and Applications in Drug Discovery and Development. :66-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3991dcf4207ab51c0c95150bab07fb6a
https://doi.org/10.4155/fseb2013.13.89
https://doi.org/10.4155/fseb2013.13.89
Autor:
Susan Binford, Heather Skor, Angelica Linton, Sadayappan V. Rahavendran, Stephanie T. Shi, Amy K. Patick, Javier Gonzalez, Jim Nonomiya, Hui Li, Koleen J. Herlihy, Rebecca Irvine, Joanne P. Graham, Tatlock John H, Cristina Lewis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2544-2552
PF-00868554 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, which exerts its inhibitory effect by binding to the thumb base domain of the protein. It is a potent and selective inhibitor, with a mean 50% inhibitory concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d5d989d1dcca84d656040423788e62
https://doi.org/10.1128/aac.01599-08
https://doi.org/10.1128/aac.01599-08
Autor:
Javier Gonzalez, Jim Nonomiya, Angelica Linton, Leena Patel, Hui Li, Fannie Chau, Hans E. Parge, Sadayappan V. Rahavendran, Heather Skor, Michael J. Hickey, Tanya Michelle Jewell, Matthew Drowns, Stephanie T. Shi, Robert P. Hunter, Cristina Lewis, Sarah Ludlum, Tatlock John H, Koleen J. Herlihy, Xiu Yu
Publikováno v:
Journal of Medicinal Chemistry. 52:1255-1258
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516b6514f4d3e027e767a1cee7f347f3
https://doi.org/10.1021/jm8014537
https://doi.org/10.1021/jm8014537
Autor:
Tatlock John H, Cristina Lewis, Mel Abreo, Stephanie T. Shi, Michele Yang, Shella A. Fuhrman, Heather Skor, Sarah Ludlum, Tanya Michelle Jewell, Mike Goble, Angelica Linton, Julie Blazel, Allen J. Borchardt, Ravi Rahavendran, Hui Li, Javier Gonzalez, Matthew Drowns, Leena Patel
Publikováno v:
Journal of Medicinal Chemistry. 50:3969-3972
The discovery and optimization of a novel class of carbon-linked dihydropyrones as allosteric HCV NS5B polymerase inhibitors are presented. Replacement of the sulfur linker atom with carbon reduced compound acidity and greatly increased cell permeati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c3227fff4427d1e8157ee4b507c61e
https://doi.org/10.1021/jm0704447
https://doi.org/10.1021/jm0704447
Publikováno v:
Handbook of LC-MS Bioanalysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef80393a5d4c30e635323c6a3e1a5235
https://doi.org/10.1002/9781118671276.ch50
https://doi.org/10.1002/9781118671276.ch50
Autor:
John E. Blume, W. Daniel Hillis, Heather Skor, William F. Smith, Lisa J. Croner, Athit Kao, Bruce Wilcox, Ryan Preston, Ryan W. Benz, Roslyn Dillon, Scott R. Schreckengaust, Naveen Babbar, Phong Cun, Genna Boragine, Stefanie N. Kairs, Ted Burrell, Jia You, David B. Agus, Ellen B. Christie, Jeffrey J. Jones
Publikováno v:
Clinical Colorectal Cancer. 15:186-194.e13
Introduction Colorectal cancer (CRC) testing programs reduce mortality; however, approximately 40% of the recommended population who should undergo CRC testing does not. Early colon cancer detection in patient populations ineligible for testing, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a540bf6d002db1a9dd930c61c75ebf1
https://doi.org/10.1016/j.clcc.2016.02.004
https://doi.org/10.1016/j.clcc.2016.02.004
Autor:
Leslie Nguyen, Bhasker Shetty, Minerva R. Batugo, Heather Skor, Zhongzhou Shen, Sylvia Vekich, Sadayappan V. Rahavendran
Publikováno v:
Bioanalysis. 4(9)
Background: Initial pharmacokinetic (PK) studies of discovery compounds are conducted in mice to demonstrate exposure prior to conducting efficacy studies. PK information obtained from a single mouse by serial blood microsampling, dried blood spot co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6774ba597d2defca200e745074e400a
https://pubmed.ncbi.nlm.nih.gov/22612688
https://pubmed.ncbi.nlm.nih.gov/22612688
Autor:
Kutbuddin S. Doctor, William F. Smith, Bruce Wilcox, Jeffrey J. Jones, Heather Skor, John E. Blume, Thomas P. Stockfisch, Scott R. Schreckengaust, Ryan W. Benz, Lisa J. Croner, Roslyn Dillon
Publikováno v:
Gastroenterology. 144:S-527
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df3d90144b6602cb396b8bec661a9d70
https://doi.org/10.1016/s0016-5085(13)61959-9
https://doi.org/10.1016/s0016-5085(13)61959-9
Autor:
Hui Li, John Tatlock, Angelica Linton, Javier Gonzalez, Tanya Jewell, Leena Patel, Sarah Ludlum, Matthew Drowns, Sadayappan V. Rahavendran, Heather Skor, Robert Hunter, Stephanie T. Shi, Koleen J. Herlihy, Hans Parge, Michael Hickey, Xiu Yu, Fannie Chau, Jim Nonomiya, Cristina Lewis
Publikováno v:
Journal of Medicinal Chemistry; Mar2009, Vol. 52 Issue 5, p1255-1258, 4p