Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Heather Sheppard"'
Autor:
Sara G. Danielli, Yun Wei, Michael A. Dyer, Elizabeth Stewart, Heather Sheppard, Marco Wachtel, Beat W. Schäfer, Anand G. Patel, David M. Langenau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Rhabdomyosarcoma (RMS) is a pediatric tumor that resembles undifferentiated muscle cells; yet the extent to which cell state heterogeneity is shared with human development has not been described. Using single-cell/nucleus RNA sequencing from
Externí odkaz:
https://doaj.org/article/e29faed2ad884c858ba654d0b6fb5c27
Autor:
Richard H. Chapple, Xueying Liu, Sivaraman Natarajan, Margaret I. M. Alexander, Yuna Kim, Anand G. Patel, Christy W. LaFlamme, Min Pan, William C. Wright, Hyeong-Min Lee, Yinwen Zhang, Meifen Lu, Selene C. Koo, Courtney Long, John Harper, Chandra Savage, Melissa D. Johnson, Thomas Confer, Walter J. Akers, Michael A. Dyer, Heather Sheppard, John Easton, Paul Geeleher
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a bette
Externí odkaz:
https://doaj.org/article/fc1c31cafd514273af4f2d422016e1f2
Autor:
Christopher E. Grant, Amy L. Flis, Leila Toulabi, Adriana Zingone, Emily Rossi, Krist Aploks, Heather Sheppard, Bríd M. Ryan
Publikováno v:
Molecular Oncology, Vol 18, Iss 6, Pp 1631-1648 (2024)
Dopamine (DA) acts in various key neurological and physiological processes as both a neurotransmitter and circulating hormone. Over the past several decades, the DA signaling network has been shown to regulate the progression of several types of soli
Externí odkaz:
https://doaj.org/article/14bcc8545fa94d06aaec7e94a26f8d35
Autor:
Timothy I. Shaw, Jessica Wagner, Liqing Tian, Elizabeth Wickman, Suresh Poudel, Jian Wang, Robin Paul, Selene C. Koo, Meifen Lu, Heather Sheppard, Yiping Fan, Francis H. O’Neill, Ching C. Lau, Xin Zhou, Jinghui Zhang, Stephen Gottschalk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Immunotherapy with chimeric antigen receptor T cells for pediatric solid and brain tumors is constrained by available targetable antigens. Cancer-specific exons present a promising reservoir of targets; however, these have not been explored
Externí odkaz:
https://doaj.org/article/a7f623660f4c451a9230c9fee62ee7a1
Autor:
Jorge Ibanez, Nikhil Hebbar, Unmesha Thanekar, Zhongzhen Yi, Haley Houke, Meghan Ward, Chris Nevitt, Liqing Tian, Stephen C. Mack, Heather Sheppard, Jason Chiang, M. Paulina Velasquez, Giedre Krenciute
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103422- (2024)
Summary: Immune synapse (IS) formation determines T cell antitumor activity. Here, we present a protocol for characterizing the IS formation between chimeric antigen receptor (CAR) T cells and tumor cells by measuring the IS size and calcium flux by
Externí odkaz:
https://doaj.org/article/8b928a25c09a49fd8380df49b4e3b51d
Autor:
Jie Fang, Shivendra Singh, Changde Cheng, Sivaraman Natarajan, Heather Sheppard, Ahmed Abu-Zaid, Adam D. Durbin, Ha Won Lee, Qiong Wu, Jacob Steele, Jon P. Connelly, Hongjian Jin, Wenan Chen, Yiping Fan, Shondra M. Pruett-Miller, Jerold E. Rehg, Selene C. Koo, Teresa Santiago, Joseph Emmons, Stefano Cairo, Ruoning Wang, Evan S. Glazer, Andrew J. Murphy, Taosheng Chen, Andrew M. Davidoff, Carolina Armengol, John Easton, Xiang Chen, Jun Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that re
Externí odkaz:
https://doaj.org/article/518df2bf603d4dbaa5922a65b63e4a51
Autor:
Ane Korff, Xiaojing Yang, Kevin O’Donovan, Abner Gonzalez, Brett J.W. Teubner, Haruko Nakamura, James Messing, Fen Yang, Alexandre F. Carisey, Yong-Dong Wang, Tushar Patni, Heather Sheppard, Stanislav S. Zakharenko, Yuh Min Chook, J. Paul Taylor, Hong Joo Kim
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Mutations in HNRNPH2 cause an X-linked neurodevelopmental disorder with features that include developmental delay, motor function deficits, and seizures. More than 90% of patients with hnRNPH2 have a missense mutation within or adjacent to the nuclea
Externí odkaz:
https://doaj.org/article/fa138194ad644570a89384252f1d094a
Autor:
Stephen Gottschalk, Phuong Nguyen, Christopher DeRenzo, Giedre Krenciute, Alex N Beckett, Peter Chockley, Shondra M Pruett-Miller, Peter Vogel, Heather Sheppard
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells. Limited studies have evaluated CD47-chimeric antigen receptor (CAR) T cells, and the role o
Externí odkaz:
https://doaj.org/article/0dce8e42cb164bc3af9c4f217878a8e2
Autor:
Richard H. Chapple, Xueying Liu, Sivaraman Natarajan, Margaret I.M. Alexander, Yuna Kim, Anand G. Patel, Christy W. LaFlamme, Min Pan, William C. Wright, Hyeong-Min Lee, Yinwen Zhang, Meifen Lu, Selene C. Koo, Courtney Long, John Harper, Chandra Savage, Melissa D. Johnson, Thomas Confer, Walter J. Akers, Michael A. Dyer, Heather Sheppard, John Easton, Paul Geeleher
Neuroblastoma is a common pediatric cancer, where preclinical studies have suggested chemotherapy resistance is driven by a mesenchymal-like gene expression program. However, the poor clinical outcomes imply we need a better understanding of the rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ac36f096d7467cac33a3f05a5d353e
https://doi.org/10.1101/2023.04.13.536639
https://doi.org/10.1101/2023.04.13.536639
Autor:
Yen-Nien Liu, Jiaoti Huang, Heather Sheppard-Tillman, Juan Juan Yin, Wei-Yu Chen, Yung-Sheng Chang
(A and B) TWIST1 (A) and miR-1 (B) expressions in patient samples at different clinical stages in the prostate cancer samples collected and analyzed at MSKCC. * vs. T2A. * p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30454a95df9e3b983249b78acd455c9b
https://doi.org/10.1158/0008-5472.22406153
https://doi.org/10.1158/0008-5472.22406153