Výsledky vyhledávání - "Heather Seidle"

Akademický článek

Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation.

Autor: Arthur Tsang, Heather Seidle, Safdar Jawaid, Weidong Zhou, Clint Smith, Robin D Couch

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20884 (2011)

Deliberate and natural outbreaks of infectious disease, the prevalence of antibiotic resistant strains, and the ease by which antibiotic resistant bacteria can be intentionally engineered all underscore the necessity of effective vaccines and continu

Externí odkaz: https://doaj.org/article/762c7dbd72bc48609a976f459be7d882

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Akademický článek

Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

Autor: Safdar Jawaid, Heather Seidle, Weidong Zhou, Hafsa Abdirahman, Maher Abadeer, Joseph H Hix, Monique L van Hoek, Robin D Couch

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8288 (2009)

Deliberate and natural outbreaks of infectious disease underscore the necessity of effective vaccines and antimicrobial/antiviral therapeutics. The prevalence of antibiotic resistant strains and the ease by which antibiotic resistant bacteria can be

Externí odkaz: https://doaj.org/article/6451db2cede94690b0d6693703a99824

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Characterization of a nonspecific phosphopantetheinyl transferase from Pseudomonas syringae pv. syringae FF5

Autor: Ronald J. Parry, Robin Couch, Heather Seidle

Publikováno v: Archives of Biochemistry and Biophysics. 446:167-174

The 4'-phosphopantetheinyl transferases (PPTases) catalyze the transfer of a 4'-phosphopantetheine moiety from coenzyme A to phosphopantetheine-dependent carrier proteins. The carrier proteins (CPs) are required for the biosynthesis of peptides synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b8fefde8f1dc3b3fd783602977f62
https://doi.org/10.1016/j.abb.2005.12.007

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Characterization of Cfa1, a Monofunctional Acyl Carrier Protein Involved in the Biosynthesis of the Phytotoxin Coronatine

Autor: Heather Seidle, Vidhya Rangaswamy, Ronald J. Parry, Carol L. Bender, Robin Couch

Publikováno v: Journal of Bacteriology. 186:2499-2503

Cfa1 was overproduced in Escherichia coli and Pseudomonas syringae , and the degree of 4′-phosphopantetheinylation was determined. The malonyl-coenzyme A:acyl carrier protein transacylase (FabD) of P. syringae was overproduced and shown to catalyze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb966941ade410f6d05422586d4611fd
https://doi.org/10.1128/jb.186.8.2499-2503.2004

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Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity

Autor: Safdar, Jawaid, Monica, Gertz, Carlin, Corsino, Jamie, Cheung, Heather, Seidle, Robin D, Couch

Publikováno v: Indian journal of biochemistrybiophysics. 47(6)

While statins, hydroxymethylglutaryl-coenzyme A reductase (HMGCR) inhibitors, are clinically proven to reduce plasma cholesterol levels, a wide variation in inter-individual response to statin therapy has been observed. Pharmacogenetic studies have i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e4480c5f263fa36cef088a8cec47d52
https://pubmed.ncbi.nlm.nih.gov/21355415

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Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation

Autor: Clint B. Smith, Heather Seidle, Arthur Tsang, Robin D. Couch, Safdar Jawaid, Weidong Zhou

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e20884 (2011)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e25f3cd623145ab1c1b2de086255a10
https://pubmed.ncbi.nlm.nih.gov/21694781

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Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine

Autor: Heather Seidle, Christopher T. Walsh, Robin Couch, Sarah E. O'Connor, Ronald J. Parry

Publikováno v: Journal of bacteriology. 186(1)

Several pathovars of Pseudomonas syringae produce the phytotoxin coronatine (COR), which contains an unusual amino acid, the 1-amino-2-ethylcyclopropane carboxylic acid called coronamic acid (CMA), which is covalently linked to a polyketide-derived c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ecb89bf6a10c6334d0b3880b35c35f
https://pubmed.ncbi.nlm.nih.gov/14679222

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