Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Heather Schmidt"'
Autor:
Changxu Fan, Xiaoyun Xing, Samuel J. H. Murphy, Jennifer Poursine-Laurent, Heather Schmidt, Bijal A. Parikh, Jeesang Yoon, Mayank N. K. Choudhary, Naresha Saligrama, Sytse J. Piersma, Wayne M. Yokoyama, Ting Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Comparative genomics has revealed the rapid expansion of multiple gene families involved in immunity. Members within each gene family often evolved distinct roles in immunity. However, less is known about the evolution of their epigenome and
Externí odkaz:
https://doaj.org/article/2e1544ec47b24a0fa0e54cc35c3f6b85
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Understanding how heterogeneous β-cell function impacts diabetes is imperative for therapy development. Standard single-cell RNA sequencing analysis illuminates some factors driving heterogeneity, but new strategies are required
Externí odkaz:
https://doaj.org/article/cb66e9ebff3f4a4795a0f4944d648a14
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here the authors show transposable elements, formerly considered junk DNA, are a source of CTCF binding sites that contribute to species-specific 3D-genome structure, and may impact gene regulation during the course of mammalian evolution.
Externí odkaz:
https://doaj.org/article/3e5b04c52e4b40f4bb3b5cc423a9dd70
Autor:
Mario A. Miranda, Celine L. St Pierre, Juan F. Macias-Velasco, Huyen Anh Nguyen, Heather Schmidt, Lucian T. Agnello, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Iron is a critical component of metabolic homeostasis, but consumption of dietary iron has increased dramatically in the last 30 years, corresponding with the rise of metabolic disease. While the link between iron metabolism and m
Externí odkaz:
https://doaj.org/article/40fed4ce4ae24cfeb19bfe9e6fc0fc02
Autor:
Mario A. Miranda, Caryn Carson, Celine L. St. Pierre, Juan F. Macias‐Velasco, Jing W. Hughes, Marcus Kunzmann, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Physiological Reports, Vol 8, Iss 20, Pp n/a-n/a (2020)
Abstract Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are unknown. High fat‐fed SM/J mice spontaneously tr
Externí odkaz:
https://doaj.org/article/ac1457641c834e28b3bd00915e615bb4
Autor:
Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108237- (2020)
Summary: We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed SM/J mice initially develop poor glucose homeostasis relative to controls. Strikingly, their glycemic dysfunction resolves by 30 weeks of age despite persiste
Externí odkaz:
https://doaj.org/article/a6b2ac652f3f4af58c41b82a97fc3808
Autor:
Christopher A. Miller, Christopher Tricarico, Zachary L. Skidmore, Geoffrey L. Uy, Yi-Shan Lee, Anjum Hassan, Michelle D. O'Laughlin, Heather Schmidt, Ling Tian, Eric J. Duncavage, Malachi Griffith, Obi L. Griffith, John S. Welch, Lukas D. Wartman
Publikováno v:
Blood Advances, Vol 2, Iss 11, Pp 1295-1299 (2018)
Externí odkaz:
https://doaj.org/article/77dac94e86d74c30978bfc528a44e654
Autor:
Obi L. Griffith, Szeman Ruby Chan, Malachi Griffith, Kilannin Krysiak, Zachary L. Skidmore, Jasreet Hundal, Julie A. Allen, Cora D. Arthur, Daniele Runci, Mattia Bugatti, Alexander P. Miceli, Heather Schmidt, Lee Trani, Krishna-Latha Kanchi, Christopher A. Miller, David E. Larson, Robert S. Fulton, William Vermi, Richard K. Wilson, Robert D. Schreiber, Elaine R. Mardis
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 249-260 (2016)
Estrogen receptor alpha-positive (ERα+) luminal tumors are the most frequent subtype of breast cancer. Stat1−/− mice develop mammary tumors that closely recapitulate the biological characteristics of this cancer subtype. To identify transforming
Externí odkaz:
https://doaj.org/article/6737bbc4d4f249dfa5517ca827b51afa
Autor:
Heather Schmidt
Publikováno v:
Collected Essays on Learning and Teaching, Vol 7, Iss 2 (2014)
We explored student motivations for attending university, including how motivations may change over the course of one’s postsecondary career, by conducting semi-structured interviews with 8 upper-year undergraduates. Participants were also asked to
Externí odkaz:
https://doaj.org/article/69053568975444009e98c122c6999df6
Autor:
Heather Schmidt
Publikováno v:
Collected Essays on Learning and Teaching, Vol 7, Iss 1 (2014)
Cultural safety reflects the extent to which an individual feels that their culture is respected, accepted and understood by the larger society in which they live.The concept was originally developed in the context of Indigenous Peoples, but it could
Externí odkaz:
https://doaj.org/article/c73044d5fe5c44ec95fd3edde6c07bf9