Výsledky vyhledávání - "Heather Sahm"

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the 'active state' of its GTPase domain

Autor: Heather Sahm, Zhong Yin Zhang, Todd A. Stone, Sheng Zhang, Kurt W. Vogel, Mu Wang, Dali Liu, Mark R. Cookson, Jingling Liao, Christopher Burlak, Quyen Q. Hoang, R. Jeremy Nichols, Mark Federici, Chun Xiang Wu, Steve Riddle

Publikováno v: Proceedings of the National Academy of Sciences. 111:4055-4060

Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase domain of LRRK2 leads to overactivation of its kinase domain. However, the mechanism by which this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9656b51240703e2457e787d01c943f
https://doi.org/10.1073/pnas.1323285111

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Targeted quantitative analysis of superoxide dismutase 1 in cisplatin-sensitive and cisplatin-resistant human ovarian cancer cells

Autor: Heather Sahm, Tony J. Tegeler, Bei Nie, Jong Won Kim, Jin Sam You, Mu Wang, Dawn P. G. Brown

Publikováno v: Journal of Chromatography B. 878:700-704

Protein quantification in a complex protein mixture presents a daunting task in biochemical analysis. Antibody-based immunoassays are traditional methods for protein quantification. However, there are issues associated with accuracy and specificity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c464fc70667e9b412d2fafbacf0e8b1
https://doi.org/10.1016/j.jchromb.2010.01.013

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Proteomic Characterization of Cerebrospinal Fluid from Ataxia-Telangiectasia (A-T) Patients Using a LC/MS-Based Label-Free Protein Quantification Technology

Autor: Thomas O. Crawford, Jinsam You, Guihong Qi, Monika Dzieciatkowska, Heather Sahm, Lawrence M. Gelbert, Kerry G. Bemis, Mu Wang, Cynthia Rothblum-Oviatt, Howard M. Lederman

Publikováno v: International Journal of Proteomics

Cerebrospinal fluid (CSF) has been used for biomarker discovery of neurodegenerative diseases in humans since biological changes in the brain can be seen in this biofluid. Inactivation of A-T-mutated protein (ATM), a multifunctional protein kinase, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4c0cacd468b0016b44e534745d4908
https://pubmed.ncbi.nlm.nih.gov/22084690

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A Potential Biomarker Panel of Multiple Myeloma Identified Using Label-Free Mass Spectrometry-Based Quantitative Proteomics

Autor: Colin D. Crean, Rafat Abonour, Heather Sahm, Attaya Suvannasankha, Sherif S. Farag, Mu Wang

Publikováno v: Blood. 118:2890-2890

Abstract 2890 Background: Multiple myeloma is an incurable and fatal hematologic malignancy. Recent gene microarray studies showed distinct gene expression profiles defining MM subgroups and their association with cytogenetic abnormalities and treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::122673fc690cde0066d8e42e68559b1c
https://doi.org/10.1182/blood.v118.21.2890.2890

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