Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Heather S. Carr"'
Publikováno v:
Journal of Biological Chemistry. 299:104645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a311caf7efe60902f4146540ea4e844b
https://doi.org/10.1016/j.jbc.2023.104645
https://doi.org/10.1016/j.jbc.2023.104645
Autor:
Kimiya Memarzadeh, Jeffrey A. Frost, Heather S. Carr, Courtney Olsen, Andrew J. Bean, Arzu Ulu
Publikováno v:
Endocrinology. 160:1031-1043
The G(i)-coupled somatostatin receptor 2 (SST(2)) is a G protein–coupled receptor (GPCR) that mediates many of somatostatin’s neuroendocrine actions. Upon stimulation, SST(2) is rapidly internalized and transported to early endosomes before being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2148c17fffa01d374b08732cd7be549
https://doi.org/10.1210/en.2018-00865
https://doi.org/10.1210/en.2018-00865
Publikováno v:
Endocrinology
The somatostatin receptor 2A (SST2) is a G-protein-coupled receptor (GPCR) that is expressed in neuroendocrine tissues within the gastrointestinal tract and brain, and is commonly overexpressed in many neuroendocrine tumors. Moreover, SST2 agonists a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08352441cb162daa92a8372b0cff0a16
https://doi.org/10.1210/endocr/bqaa229
https://doi.org/10.1210/endocr/bqaa229
Autor:
Jeffrey A. Frost, Heather S. Carr
Publikováno v:
Journal of the Endocrine Society
Somatostatin receptor 2A (Sst2A) agonists are the primary pharmacological treatment for growth hormone (GH) secreting pituitary tumors to inhibit GH secretion and limit the destructive effects of these tumors. Sst2A agonists are also widely used as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432dd330e3890d89faf9937452e5fdab
http://europepmc.org/articles/PMC7207474
http://europepmc.org/articles/PMC7207474
Autor:
Lina Guerra, Heather S Carr, Agneta Richter-Dahlfors, Maria G Masucci, Monica Thelestam, Jeffrey A Frost, Teresa Frisan
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2254 (2008)
BackgroundExposure of adherent cells to DNA damaging agents, such as the bacterial cytolethal distending toxin (CDT) or ionizing radiations (IR), activates the small GTPase RhoA, which promotes the formation of actin stress fibers and delays cell dea
Externí odkaz:
https://doaj.org/article/13685e220b60404b877b4cb86ec0367a
Publikováno v:
Molecular Biology of the Cell
Mechanisms accounting for the role of Net1 in cell proliferation have not been described. This study shows that Net1 plays a Rho GTPase–independent role in controlling mitotic spindle assembly and kinetochore attachment and is required for centroso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef6584eafc1ef4ca1f4c9b0dafa6e74
https://doi.org/10.1091/mbc.e13-01-0061
https://doi.org/10.1091/mbc.e13-01-0061
Publikováno v:
Molecular and Cellular Biology. 33:2773-2786
Net1 is a RhoA guanine nucleotide exchange factor (GEF) that is overexpressed in a subset of human cancers and contributes to cancer cell motility and invasion in vitro. However, the molecular mechanism accounting for its role in cell motility and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334ae7bedac31321049e0c849c1cd1d6
https://doi.org/10.1128/mcb.00175-13
https://doi.org/10.1128/mcb.00175-13
Publikováno v:
Journal of Cellular Biochemistry. 105:167-175
Raf-1 is an important effector of Ras mediated signaling and is a critical regulator of the ERK/MAPK pathway. Raf-1 activation is controlled in part by phosphorylation on multiple residues, including an obligate phosphorylation site at serine 338. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c5a4d45f521dd406c6c3f39f3ad2a1
https://doi.org/10.1002/jcb.21809
https://doi.org/10.1002/jcb.21809
Autor:
Lisa Sharek, Rafael Garcia-Mata, Adi D. Dubash, Keith Burridge, Jeffrey A. Frost, Heather S. Carr
Publikováno v:
Molecular and Cellular Biology. 27:8683-8697
Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote transformation. Net1 contains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b551f96c6c0692c06174aa6e107dee
https://doi.org/10.1128/mcb.00157-07
https://doi.org/10.1128/mcb.00157-07
Publikováno v:
Journal of Cell Science.
Net1 isoform A (Net1A) is a RhoA GEF that is required for cell motility and invasion in multiple cancers. Nuclear localization of Net1A negatively regulates its activity, and we have recently shown that Rac1 stimulates Net1A relocalization to the pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832ed23fab8cc98a7b0da3b704488866
https://doi.org/10.1242/jcs.158121
https://doi.org/10.1242/jcs.158121