Výsledky vyhledávání - "Heather S Tillman"

Akademický článek

Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis

Autor: Sabrin Albeituni, Ninad Oak, Heather S. Tillman, Alexa Stroh, Camille Keenan, Mackenzie Bloom, Kim E. Nichols

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundPrimary hemophagocytic lymphohistiocytosis (pHLH) is an inherited inflammatory syndrome driven by the exuberant activation of interferon-gamma (IFNg)-producing CD8 T cells. Towards this end, ruxolitinib treatment or IFNg neutralization (aIF

Externí odkaz: https://doaj.org/article/bfcb86898f21404aaaff92d705f7b380

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Akademický článek

Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Multi-omic profiling is a powerful approach to dissecting molecular mechanisms in disease. Here the authors generate whole proteome, phosphoproteome and transcriptome profiles from two mouse models of high-grade glioma driven by different oncogenes,

Externí odkaz: https://doaj.org/article/61f32b7ce86246f7a09c004f13127043

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Akademický článek

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production

Publikováno v: JCI Insight, Vol 5, Iss 17 (2020)

Prader-Willi syndrome (PWS) is a developmental disorder caused by loss of maternally imprinted genes on 15q11-q13, including melanoma antigen gene family member L2 (MAGEL2). The clinical phenotypes of PWS suggest impaired hypothalamic neuroendocrine

Externí odkaz: https://doaj.org/article/33ac474ecbe5477698ac12c206bee3aa

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ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma

Publikováno v: Neuro-Oncology.

Background Pediatric high-grade glioma (pHGG) is largely incurable and accounts for most brain tumor-related deaths in children. Radiation is a standard therapy, yet the benefit from this treatment modality is transient, and most children succumb to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::704ecd48a622ac941565f97e50f714af
https://doi.org/10.1093/neuonc/noad064

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Akademický článek

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Autor: Supreet Agarwal, Paul G. Hynes, Heather S. Tillman, Ross Lake, Wassim G. Abou-Kheir, Lei Fang, Orla M. Casey, Amir H. Ameri, Philip L. Martin, Juan Juan Yin, Phillip J. Iaquinta, Wouter R. Karthaus, Hans C. Clevers, Charles L. Sawyers, Kathleen Kelly

Publikováno v: Cell Reports, Vol 13, Iss 10, Pp 2147-2158 (2015)

Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53-null mouse model of prostate cancer, we show that two clas

Externí odkaz: https://doaj.org/article/10f129a7fb434bc989882304f60a11d9

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Akademický článek

TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation.

Autor: Orla M Casey, Lei Fang, Paul G Hynes, Wassim G Abou-Kheir, Philip L Martin, Heather S Tillman, Gyorgy Petrovics, Hibah O Awwad, Yvona Ward, Ross Lake, Luhua Zhang, Kathleen Kelly

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41668 (2012)

Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the pr

Externí odkaz: https://doaj.org/article/2af905f70f1c48d0bae2e21c214b0f61

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