Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Heather R. Shive"'
Autor:
Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L. Calkins, Jami Shaffer, Emily M. Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T. Charles Gregory, Shelley Orwick, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E. Carson, Heather R. Shive, James S. Blachly, Rosa Lapalombella, Leonard I. Zon, Bradley W. Blaser
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112528- (2023)
Summary: Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically barcoded genome editing of synthetic target arrays for lineage tracing (GESTALT)
Externí odkaz:
https://doaj.org/article/b0783af216d541e48c1e8e6815eda5bc
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Cancer cells frequently co-opt molecular programs that are normally activated in specific contexts, such as embryonic development and the response to injury. Determining the impact of cancer-associated mutations on cellular phenotypes within
Externí odkaz:
https://doaj.org/article/d3788dc81fb141b086f44ef0c27d2700
Autor:
Laura E. Schultz, Jeffrey A. Haltom, Maira P. Almeida, Wesley A. Wierson, Staci L. Solin, Trevor J. Weiss, Jordan A. Helmer, Elizabeth J. Sandquist, Heather R. Shive, Maura McGrail
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumor
Externí odkaz:
https://doaj.org/article/d7541aa813124c06aaa550fd7eeed8b0
Cancer cells frequently co-opt molecular programs that are normally activated in specific contexts, such as embryonic development and the response to injury. Determining the impact of cancer-associated mutations on cellular phenotypes within these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92290d44547daab546e41ef7e540e844
https://doi.org/10.1101/2021.08.20.457131
https://doi.org/10.1101/2021.08.20.457131
Autor:
Heather R. Shive, John S. House, Jordan L. Ferguson, Dereje D. Jima, Aubrie A. Selmek, Dillon T. Lloyd
Publikováno v:
Clinical Cancer Research. 28:PR011-PR011
Contributions of the microenvironment to soft tissue sarcoma progression are relatively undefined, representing a major impediment to identifying essential regulatory networks in sarcomagenesis. Furthermore, genetic and molecular characteristics that
Publikováno v:
Journal of Oncology
Journal of Oncology, Vol 2019 (2019)
Journal of Oncology, Vol 2019 (2019)
Successful cell replication requires both cell cycle completion and accurate chromosomal segregation. The tumor suppressor BRCA2 is positioned to influence both of these outcomes, and thereby influence genomic integrity, during meiotic and mitotic ce
Autor:
Kerry L Simon, Matthew R Cook, Brian D Husbands, Mackenzie E Long, Jessica A Hokamp, Timothy H Helms, Heather R Shive, Sarah Lumbrezer Johnson, Eric Hostnik, Laura E Selmic
Publikováno v:
Journal of Feline Medicine and Surgery Open Reports. 8:205511692211219
Case summary A 7-year-old male castrated domestic shorthair cat presented with a 5-day history of inappetence. A mid-abdominal mass was palpated and, on exploratory laparotomy, a cystic mass arising from the root of the mesentery was observed. The ma
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87177 (2014)
Germline mutations in the tumor suppressor genes BRCA2 and TP53 significantly influence human cancer risk, and cancers from humans who inherit one mutant allele for BRCA2 or TP53 often display loss of the wildtype allele. In addition, BRCA2-associate
Externí odkaz:
https://doaj.org/article/973eb28bbb9e404a8cf74a78890a0358
Pathologic Lesions of the Budgett Frog (Lepidobatrachus laevis), an Emerging Laboratory Animal Model
Publikováno v:
Comp Med
Lepidobatrachus laevis, commonly called the Budgett frog, is a member of the horned frog family (Ceratophryidae), which has become increasingly popular among amphibian hobbyists. L. laevis is also used in biologic research on embryonic development, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076ecb7dc86ec90b0181778907eaf4e7
https://europepmc.org/articles/PMC7287390/
https://europepmc.org/articles/PMC7287390/
Autor:
Jordan L. Ferguson, Heather R. Shive
Publikováno v:
Journal of visualized experiments : JoVE
Investigation of intercellular interactions often requires discrete labeling of specific cell populations and precise protein localization. The zebrafish embryo is an excellent tool for examining such interactions with an in vivo model. Whole-mount i