Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Heather P Harding"'
Publikováno v:
eLife, Vol 13 (2024)
Activating transcription factor 6 (ATF6) is one of three endoplasmic reticulum (ER) transmembrane stress sensors that mediate the unfolded protein response (UPR). Despite its crucial role in long-term ER stress adaptation, regulation of ATF6 alpha (
Externí odkaz:
https://doaj.org/article/9433481c101a4529abf93bc4343026a9
Autor:
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitu
Externí odkaz:
https://doaj.org/article/39116a8baac7473c85e71501c8fe0c4e
Autor:
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron
Publikováno v:
eLife, Vol 8 (2019)
The eukaryotic translation initiation factor 2α (eIF2α) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as the Integrated Stress Response (ISR). A role for uncharged tRNAs as activating ligands o
Externí odkaz:
https://doaj.org/article/a51ed5f0188c4cd88251aec3835f683c
Autor:
Yusuke Sekine, Alisa Zyryanova, Ana Crespillo-Casado, Niko Amin-Wetzel, Heather P Harding, David Ron
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166278 (2016)
The eukaryotic translation initiation factor eIF2B promotes mRNA translation as a guanine nucleotide exchange factor (GEF) for translation initiation factor 2 (eIF2). Endoplasmic reticulum (ER) stress-mediated activation of the kinase PERK and the re
Externí odkaz:
https://doaj.org/article/c9a0df4ecf364e80835ef16107a8a831
Autor:
Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Juan Perez, Linda M Hendershot, Heather P Harding, David Ron
Publikováno v:
eLife, Vol 4 (2015)
DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. Site-specific proteolysis and crosslinking were used to probe the architecture of oligomers formed by the endoplasmic reticulum (ER) Hsp70, BiP. These we
Externí odkaz:
https://doaj.org/article/645adf268a244bb8b406109511db4a8a
Autor:
Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J Clarke, Heather P Harding, Stefan J Marciniak, Randy J Read, David Ron
Publikováno v:
eLife, Vol 4 (2015)
Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R
Externí odkaz:
https://doaj.org/article/d50ab94c81404b48bb62ce3b1f3927bf
Autor:
Satoshi Tsunoda, Edward Avezov, Alisa Zyryanova, Tasuku Konno, Leonardo Mendes-Silva, Eduardo Pinho Melo, Heather P Harding, David Ron
Publikováno v:
eLife, Vol 3 (2014)
Protein folding homeostasis in the endoplasmic reticulum (ER) requires efficient protein thiol oxidation, but also relies on a parallel reductive process to edit disulfides during the maturation or degradation of secreted proteins. To critically exam
Externí odkaz:
https://doaj.org/article/676eee2fd8be4f8abfed0abf85054431
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109144- (2021)
Summary: Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their secretion remain obscure. We report on a genome-wide CRISPR-Cas9 screen for genes affecting
Externí odkaz:
https://doaj.org/article/46a4f8ba641a46db88d9469383794bcc
Autor:
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitus and sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d816924c4de0973bffb20d6391665e67
https://www.repository.cam.ac.uk/handle/1810/345813
https://www.repository.cam.ac.uk/handle/1810/345813
Autor:
Rosine Dushime, Yunhuang Zhu, Hanzhi Wu, Daniel Saez, Kirtikar Shukla, Heather Brown-Harding, Maique W. Biavatti, Kimberly J. Nelson, Leslie B. Poole, William T. Lowther, Paul B. Jones, Cristina M. Furdui, Allen W. Tsang
Publikováno v:
Antioxidants, Vol 9, Iss 12, p 1220 (2020)
Chlamydia trachomatis (Ct) is a bacterial intracellular pathogen responsible for a plethora of diseases ranging from blindness to pelvic inflammatory diseases and cervical cancer. Although this disease is effectively treated with antibiotics, concern
Externí odkaz:
https://doaj.org/article/a49d12c40471419c9a0bd156d0737692