Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Heather N. Orth"'
Autor:
Matthew C. Pickering, V. Michael Holers, Alex Woodell, Heather N. Orth, Beth Coughlin, Lynne M. Mitchell, Bärbel Rohrer, Jonathan P. Hannan, Liudmila Kulik, James M. Kovacs, Joshua M. Thurman, Siranush A. Sargsyan, Dennis E. Hourcade, Maria Wong, Brandon Renner
Publikováno v:
Journal of Clinical Investigation. 123:2218-2230
During complement activation the C3 protein is cleaved, and C3 activation fragments are covalently fixed to tissues. Tissue-bound C3 fragments are a durable biomarker of tissue inflammation, and these fragments have been exploited as addressable bind
Autor:
Kathrin E. Coleman, Claudia R. Amura, Heather N. Orth, Viviana P. Ferreira, Claudio Cortes, Amanda Holland-Neidermyer, V. Michael Holers, Ryan Goldberg, Joshua M. Thurman, Kathryn Pierce, Michael K. Pangburn, Brandon Renner, Hector Molina
Publikováno v:
The Journal of Immunology. 185:3086-3094
Congenital and acquired deficiencies of complement regulatory proteins are associated with pathologic complement activation in several renal diseases. To elucidate the mechanisms by which renal tubular epithelial cells (TECs) control the complement s