Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Heather N. Frost"'
Autor:
Beau Bruneau, Kristin Surdam, Amy Bland, Amy Krueger, Andrew Wise, Ani Cotarlan, Asher Leviton, Elena Jouravleva, Grace Fitzgerald, Heather N. Frost, Honora F. Cutler, Joshua Buddle, Luis G. Diaz, Michele Cohen, Nancy A. Sacco, Ryan Washington, Susan Mauermann, Victor Chen, Andrea Bastek
Publikováno v:
Contemporary Clinical Trials Communications, Vol 40, Iss , Pp 101291- (2024)
Background: This Site Feasibility Task Force convened to assess the complex and burdensome process of site feasibility in clinical trials. The objective was to create mutual understanding of challenges and provide suggestions for improving collaborat
Externí odkaz:
https://doaj.org/article/d23830b9612b476b8897b8a2ef239bfc
Autor:
Anthony Wood, Simon Bailey, David Austen Perry, Heather N. Frost, Yvette M. Fobian, Sylvie K. Sakata, F. Christopher Bi, Xiaolan Ling, Leslie Sloan
Publikováno v:
Drug Discovery Today. 19:289-294
Confronted with the need to significantly raise the productivity of remotely located chemistry CROs Pfizer embraced a commitment to continuous improvement which leveraged the tools from both Lean Six Sigma and queue management theory to deliver posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d992a73f109b53b2684d53e89334534
https://doi.org/10.1016/j.drudis.2013.07.017
https://doi.org/10.1016/j.drudis.2013.07.017
Autor:
Kuang Tongtao, Wang Zhibo, Yuanqiang Long, Jian Li, Xin Ran, Jinshan Chen, David W. Piotrowski, Hua Yi, Cristiano Ruch Werneck Guimarães, Chonggang Liu, Frank Rong, Shai Li, Heather N. Frost, Guoyun Bai, Junwei Shen, Jieyang Tan, James Federico, Hua Yu, Kexin Xu, Li Chen, Liu Bo, Ai Chaowu, Yingfu Li, Chen Yuanwei, Zhilong Jiang, Geng Xi, Hongyun Qiao, Carrie Whitney-Pickett, Magee Thomas Victor, Bo Shan, Kai Wu, Matthew D. Troutman, Mark C. Noe, Dale Gordon Mcleod, Youpei Chen, Jing Du, Gilles H. Goetz, Dapeng Zhao, Qiu Gao, Li Xiaoyong, Changqing Shi
Publikováno v:
Tetrahedron Letters. 54:3298-3301
We report novel syntheses of 12-membered macrocyclic templates and a library of 4000 macrocyclic analogs. The key macrocyclization step was performed at up to 100 g scale without resorting to syringe pumps, flow reactors or large volumes of solvent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e188654e519db141ac2ddc51f9b94f
https://doi.org/10.1016/j.tetlet.2013.04.058
https://doi.org/10.1016/j.tetlet.2013.04.058
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094fb50746e9612e49cef7a5bc7bf6
https://doi.org/10.1016/j.bmcl.2013.03.012
https://doi.org/10.1016/j.bmcl.2013.03.012
Autor:
Joel M. Hawkins, Lulin Wei, Dennis E. Bourassa, Peter Robert Rose, Jeffery W. Raggon, A. Morgan Stewart, Heather N. Frost, James E. Phillips, Jennifer Lea Rutherford, Michael J. Castaldi, Barbara J. Sitter, Stephen S. Massett, Phillip J. Johnson, Michael G. Vetelino, Thomas Andrew Brandt, David H. Brown Ripin, Karin Neumann
Publikováno v:
Organic Process Research & Development. 9:440-450
The synthesis of the anti-cancer compound 2-methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)phenylamino]quinazolin-6-yl}-E-allyl)acetamide (CP-724,714) (1) on multikilogram scale using several different synthetic routes is described. Applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5fded034f53a5be141f6f46ced0a248
https://doi.org/10.1021/op050039u
https://doi.org/10.1021/op050039u
Autor:
Timothy D. White, Jay F. Stearns, Heather N. Frost, Ashwin M. Krishnan, James E. Phillips, Ruggeri Sally G, James L. Colony, Duane J. Mazur, Weiling Cai, Teresa W. Makowski, David H. Brown Ripin, Peter M. Kendall, James P. Hudspeth
Publikováno v:
Organic Process Research & Development. 9:51-56
Two routes for the synthesis of cis-N-protected-3-methylamino-4-methylpiperidine (3) were examined: a route hinging on the electrochemical oxidation of carbamate 1 to install a ketone at the 3 position of the piperidine followed by reductive aminatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d7c980f02c5aa5a94d2e5d6999c2fb
https://doi.org/10.1021/op049808k
https://doi.org/10.1021/op049808k
Autor:
Heather N. Frost, David H. Brown Ripin
Publikováno v:
Practical Synthetic Organic Chemistry: Reactions, Principles, and Techniques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e5a22c6cacf63699dc70204d336e0b
https://doi.org/10.1002/9781118093559.ch17
https://doi.org/10.1002/9781118093559.ch17
Autor:
Maxime Bergeron, Heather N. Frost, Xavier Pigeon, Francis Barabé, Pascal Dube, Jean-François Paquin
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f714d32022d384703684c510377de7d
https://doi.org/10.1002/chin.201021042
https://doi.org/10.1002/chin.201021042
Autor:
Teresa W. Makowski, Ruth E. McDermott, Paige Roanne Palmer Brooks, Michael C. Wirtz, Crystal G. Bashore, Michael G. Vetelino, John A. Ragan, David C. Whritenour, Jotham Wadsworth Coe, Heather N. Frost, Steven J. Brenek, Jennifer Lea Rutherford
Publikováno v:
Organic letters. 8(26)
[Structure: see text] The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80965a90b4448a18d3169e58916042b
https://pubmed.ncbi.nlm.nih.gov/17165901
https://pubmed.ncbi.nlm.nih.gov/17165901
Publikováno v:
ChemInform. 35
Three families of ligands were prepared for use in Pd-catalyzed aryl aminations and possibly other Pd-catalyzed reactions. The first series is derived from diarylsulfones, the second from trityl imidazole, and the third from 2-bromobenzophenone. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c81b2fe5f7b61f28ee12535d1d7e35
https://doi.org/10.1002/chin.200438083
https://doi.org/10.1002/chin.200438083