Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heather N. Andrews"'
Autor:
Jill E. Kucab, Valentina Evdokimova, Sandra E. Dunn, C. Blake Gilks, Christy Brookes, Torsten O. Nielsen, Leonard M. Neckers, Heather N. Andrews, David G. Huntsman, Nikita Makretsov, Forrest D. Hsu, Maggie C.U. Cheang, Joseph Ragaz, Chris Bajdik
Publikováno v:
Cancer Research. 64:286-291
Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are under way to identify uPA inhibitors. By screening a chemical library of >1000 compounds, 17-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7756af3e1bfcecd8b5f69a78b1f4b5c2
https://doi.org/10.1158/0008-5472.can-03-1242
https://doi.org/10.1158/0008-5472.can-03-1242
Autor:
Jennifer E. Quinn, Paula M. Gilmore, Richard D. Kennedy, Michael Carty, Paul B. Mullan, Denis Paul Harkin, Heather N. Andrews, Nuala McCabe
Publikováno v:
Biochemical Society Transactions. 31:257-262
BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor gene that is mutated in the germline of women with a genetic predisposition to breast and ovarian cancer. In this review, we examine the role played by BRCA1 in mediating the cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d3bf3fce9730739622c5ec266732757
https://doi.org/10.1042/bst0310257
https://doi.org/10.1042/bst0310257
Autor:
Daniel A. Haber, Nuala McCabe, Amy J. Pace, Paul B. Mullan, Heather N. Andrews, Stewart McWilliams, Patrick G. Johnston, Beverly H. Koller, D. Paul Harkin, Jennifer E. Quinn, Paula M. Gilmore, Šárka Šebelová
Publikováno v:
Journal of Biological Chemistry. 277:26225-26232
BRCA1 is a tumor suppressor gene implicated in transcriptional regulation. We have generated cell lines with inducible expression of BRCA1 as a tool to identify downstream targets that may be important mediators of BRCA1 function. Oligonucleotide arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db037831379704e8b36d9f0d628b19d6
https://doi.org/10.1074/jbc.m201316200
https://doi.org/10.1074/jbc.m201316200
Publikováno v:
Breast Cancer Research and Treatment. 59:199-209
Our previous studies have shown that social housing conditions can significantly alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study extended our investigations to the molecular level by examining stressor effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1986c1261fa1a407fbf5909adb38e6b
https://doi.org/10.1023/a:1006314010958
https://doi.org/10.1023/a:1006314010958
Publikováno v:
Neurotoxicology and Teratology. 22:89-102
Stressful life events and the ability to cope with stress may play a role in the progression of breast cancer; however, the complex relationship between stressors and tumor growth is difficult to investigate in humans. Our studies have utilized the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba4692ce7e13b667207aeec59bbd726
https://doi.org/10.1016/s0892-0362(99)00049-5
https://doi.org/10.1016/s0892-0362(99)00049-5
Autor:
Nancy Dos, Santos, Golareh, Habibi, Michelle, Wang, Jennifer H, Law, Heather N, Andrews, Daniel, Wei, Timothy, Triche, Shoukat, Dedhar, Sandra E, Dunn
Publikováno v:
Translational Oncogenomics
Urokinase-type plasminogen activator (uPA) is associated with cancer recurrence where the most evidence comes from studies in breast cancer. According to the European Organization for Research and Treatment of Cancer, uPA is considered one of the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::737597bce4f74e5acfb4599dbe9c4a61
https://pubmed.ncbi.nlm.nih.gov/23645983
https://pubmed.ncbi.nlm.nih.gov/23645983
Publikováno v:
Psychosomatic medicine. 68(6)
OBJECTIVE To identify possible hormonal factors involved in the differential responses to chemotherapy observed in our tumor model, we investigated if the timing among tumor cell injection, rehousing, and chemotherapy administration differentially af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985dfcec6d37074b1b6f43a66a11c23e
https://pubmed.ncbi.nlm.nih.gov/17132842
https://pubmed.ncbi.nlm.nih.gov/17132842
Publikováno v:
Breast cancer research and treatment. 94(1)
Elevated urokinase-type plasminogen activator (uPA) expression in breast tumors predicts poor survival. We found celecoxib (25 microM) significantly reduced uPA protein and mRNA in MDA-MB-231 breast cancer cells following 72 h of treatment. Celecoxib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90282af103b8e0c5e234c560fc1f3695
https://pubmed.ncbi.nlm.nih.gov/16172791
https://pubmed.ncbi.nlm.nih.gov/16172791
Autor:
Paul B. Mullan, Jennifer E. Quinn, Nuala McCabe, Richard D. Kennedy, Stewart McWilliams, Michael Carty, W. Paul Duprex, Edison T. Liu, Julia J. Gorski, D. Paul Harkin, Patrick G. Johnston, Heather N. Andrews, Paula M. Gilmore
Publikováno v:
Cancer research. 64(12)
BRCA1 has been implicated in a number of cellular processes, including transcriptional regulation, DNA damage repair, cell cycle arrest, and apoptosis. We identified mitogen-activated protein kinase (MAPK) kinase kinase 3 (MEKK3), an upstream regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096c1824a75420aed6793e19abc39ff5
https://pubmed.ncbi.nlm.nih.gov/15205325
https://pubmed.ncbi.nlm.nih.gov/15205325
Autor:
Torsten O, Nielsen, Heather N, Andrews, Maggie, Cheang, Jill E, Kucab, Forrest D, Hsu, Joseph, Ragaz, C Blake, Gilks, Nikita, Makretsov, Chris D, Bajdik, Christy, Brookes, Leonard M, Neckers, Valentina, Evdokimova, David G, Huntsman, Sandra E, Dunn
Publikováno v:
Cancer research. 64(1)
Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are under way to identify uPA inhibitors. By screening a chemical library of1000 compounds, 17-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::285563df634236803e489967eed25ad4
https://pubmed.ncbi.nlm.nih.gov/14729636
https://pubmed.ncbi.nlm.nih.gov/14729636