Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Heather N. Andrews"'
Autor:
Jill E. Kucab, Valentina Evdokimova, Sandra E. Dunn, C. Blake Gilks, Christy Brookes, Torsten O. Nielsen, Leonard M. Neckers, Heather N. Andrews, David G. Huntsman, Nikita Makretsov, Forrest D. Hsu, Maggie C.U. Cheang, Joseph Ragaz, Chris Bajdik
Publikováno v:
Cancer Research. 64:286-291
Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are under way to identify uPA inhibitors. By screening a chemical library of >1000 compounds, 17-
Autor:
Jennifer E. Quinn, Paula M. Gilmore, Richard D. Kennedy, Michael Carty, Paul B. Mullan, Denis Paul Harkin, Heather N. Andrews, Nuala McCabe
Publikováno v:
Biochemical Society Transactions. 31:257-262
BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor gene that is mutated in the germline of women with a genetic predisposition to breast and ovarian cancer. In this review, we examine the role played by BRCA1 in mediating the cellular
Autor:
Daniel A. Haber, Nuala McCabe, Amy J. Pace, Paul B. Mullan, Heather N. Andrews, Stewart McWilliams, Patrick G. Johnston, Beverly H. Koller, D. Paul Harkin, Jennifer E. Quinn, Paula M. Gilmore, Šárka Šebelová
Publikováno v:
Journal of Biological Chemistry. 277:26225-26232
BRCA1 is a tumor suppressor gene implicated in transcriptional regulation. We have generated cell lines with inducible expression of BRCA1 as a tool to identify downstream targets that may be important mediators of BRCA1 function. Oligonucleotide arr
Publikováno v:
Breast Cancer Research and Treatment. 59:199-209
Our previous studies have shown that social housing conditions can significantly alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study extended our investigations to the molecular level by examining stressor effects
Publikováno v:
Neurotoxicology and Teratology. 22:89-102
Stressful life events and the ability to cope with stress may play a role in the progression of breast cancer; however, the complex relationship between stressors and tumor growth is difficult to investigate in humans. Our studies have utilized the a
Autor:
Nancy Dos, Santos, Golareh, Habibi, Michelle, Wang, Jennifer H, Law, Heather N, Andrews, Daniel, Wei, Timothy, Triche, Shoukat, Dedhar, Sandra E, Dunn
Publikováno v:
Translational Oncogenomics
Urokinase-type plasminogen activator (uPA) is associated with cancer recurrence where the most evidence comes from studies in breast cancer. According to the European Organization for Research and Treatment of Cancer, uPA is considered one of the mos
Publikováno v:
Psychosomatic medicine. 68(6)
OBJECTIVE To identify possible hormonal factors involved in the differential responses to chemotherapy observed in our tumor model, we investigated if the timing among tumor cell injection, rehousing, and chemotherapy administration differentially af
Publikováno v:
Breast cancer research and treatment. 94(1)
Elevated urokinase-type plasminogen activator (uPA) expression in breast tumors predicts poor survival. We found celecoxib (25 microM) significantly reduced uPA protein and mRNA in MDA-MB-231 breast cancer cells following 72 h of treatment. Celecoxib
Autor:
Paul B. Mullan, Jennifer E. Quinn, Nuala McCabe, Richard D. Kennedy, Stewart McWilliams, Michael Carty, W. Paul Duprex, Edison T. Liu, Julia J. Gorski, D. Paul Harkin, Patrick G. Johnston, Heather N. Andrews, Paula M. Gilmore
Publikováno v:
Cancer research. 64(12)
BRCA1 has been implicated in a number of cellular processes, including transcriptional regulation, DNA damage repair, cell cycle arrest, and apoptosis. We identified mitogen-activated protein kinase (MAPK) kinase kinase 3 (MEKK3), an upstream regulat
Autor:
Torsten O, Nielsen, Heather N, Andrews, Maggie, Cheang, Jill E, Kucab, Forrest D, Hsu, Joseph, Ragaz, C Blake, Gilks, Nikita, Makretsov, Chris D, Bajdik, Christy, Brookes, Leonard M, Neckers, Valentina, Evdokimova, David G, Huntsman, Sandra E, Dunn
Publikováno v:
Cancer research. 64(1)
Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are under way to identify uPA inhibitors. By screening a chemical library of1000 compounds, 17-al