Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Heather Mulder"'
Autor:
Andrew J. Murphy, Changde Cheng, Justin Williams, Timothy I. Shaw, Emilia M. Pinto, Karissa Dieseldorff-Jones, Jack Brzezinski, Lindsay A. Renfro, Brett Tornwall, Vicki Huff, Andrew L. Hong, Elizabeth A. Mullen, Brian Crompton, Jeffrey S. Dome, Conrad V. Fernandez, James I. Geller, Peter F. Ehrlich, Heather Mulder, Ninad Oak, Jamie Maciezsek, Carolyn M. Jablonowski, Andrew M. Fleming, Prahalathan Pichavaram, Christopher L. Morton, John Easton, Kim E. Nichols, Michael R. Clay, Teresa Santiago, Jinghui Zhang, Jun Yang, Gerard P. Zambetti, Zhaoming Wang, Andrew M. Davidoff, Xiang Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing (n = 85 tumors from 61 patients with matched germlin
Externí odkaz:
https://doaj.org/article/946f460fad5e41959f9465bb4f236137
Autor:
Sonali Narang, Nikki A. Evensen, Jason Saliba, Joanna Pierro, Mignon L. Loh, Patrick A. Brown, Pandurang Kolekar, Heather Mulder, Ying Shao, John Easton, Xiaotu Ma, Aristotelis Tsirigos, William L. Carroll
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background The NSD2 p.E1099K (EK) mutation is shown to be enriched in patients with relapsed acute lymphoblastic leukemia (ALL), indicating a role in clonal evolution and drug resistance. Results To uncover 3D chromatin architecture-related
Externí odkaz:
https://doaj.org/article/2fa3e7fe8efc458a83cdfba95749aef0
Autor:
Qian Dong, Cheng Chen, Nan Song, Na Qin, Noel-Marie Plonski, Emily R. Finch, Kyla Shelton, John Easton, Heather Mulder, Emily Plyer, Geoffrey Neale, Emily Walker, Qian Li, I-Chan Huang, Jinghui Zhang, Hui Wang, Melissa M. Hudson, Leslie L. Robison, Kirsten K. Ness, Zhaoming Wang
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background DNA methylation (DNAm) plays an important role in lipid metabolism, however, no epigenome-wide association study (EWAS) of lipid levels has been conducted among childhood cancer survivors. Here, we performed EWAS analysis with lon
Externí odkaz:
https://doaj.org/article/b732bfd52f4840fc9346c01ff04bd7c9
Autor:
Nan Song, Qian Dong, Cheng Chen, Qian Li, Heather Mulder, Emily Plyler, John Easton, Emily Walker, Scott Olson, Geoffrey Neale, Kevin R. Krull, Deo Kumar Srivastava, Kirsten K. Ness, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, I‐Chan Huang, Zhaoming Wang
Publikováno v:
Cancer Communications, Vol 43, Iss 2, Pp 290-293 (2023)
Externí odkaz:
https://doaj.org/article/64181acdb1b04303a3793f9c774a95a2
Autor:
Nan Song, Jin-Ah Sim, Qian Dong, Yinan Zheng, Lifang Hou, Zhenghong Li, Chia-Wei Hsu, Haitao Pan, Heather Mulder, John Easton, Emily Walker, Geoffrey Neale, Carmen L. Wilson, Kirsten K. Ness, Kevin R. Krull, Deo Kumar Srivastava, Yutaka Yasui, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, I-Chan Huang, Zhaoming Wang
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1389-1403 (2022)
Social epigenomics is an emerging field in which social scientist collaborate with computational biologists, especially epigeneticists, to address the underlying pathway for biological embedding of life experiences. This social epigenomics study incl
Externí odkaz:
https://doaj.org/article/4a3ef1b8c9a2438b9efa0c88297cce92
Autor:
Qian Dong, Nan Song, Na Qin, Cheng Chen, Zhenghong Li, Xiaojun Sun, John Easton, Heather Mulder, Emily Plyler, Geoffrey Neale, Emily Walker, Qian Li, Xiaotu Ma, Xiang Chen, I-Chan Huang, Yutaka Yasui, Kirsten K. Ness, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, Zhaoming Wang
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is associated with specific treatment exposures, unfavorable health behaviors, and presence of certain chronic health conditions. To better understand in
Externí odkaz:
https://doaj.org/article/7166156b1ce147cd98ceb6950072237e
Autor:
Nan Song, Chia-Wei Hsu, Haitao Pan, Yinan Zheng, Lifang Hou, Jin-ah Sim, Zhenghong Li, Heather Mulder, John Easton, Emily Walker, Geoffrey Neale, Carmen L. Wilson, Kirsten K. Ness, Kevin R. Krull, Deo Kumar Srivastava, Yutaka Yasui, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, I-Chan Huang, Zhaoming Wang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background It is well-established that cancer treatment substantially increases the risk of long-term adverse health outcomes among childhood cancer survivors. However, there is limited research on the underlying mechanisms. To elucidate the
Externí odkaz:
https://doaj.org/article/6d7d4d0aa6d44bc4bafc6e3d4edd8e50
Autor:
Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Elizabeth Stewart, Xin Zhou, Jongrye Jeon, Lyra Griffiths, Rosa Nguyen, Jackie Norrie, John Easton, Heather Mulder, Donald Yergeau, Yanling Liu, Jianrong Wu, Collin Van Ryn, Arlene Naranjo, Michael D. Hogarty, Marcin M. Kamiński, Marc Valentine, Shondra M. Pruett-Miller, Alberto Pappo, Jinghui Zhang, Michael R. Clay, Armita Bahrami, Peter Vogel, Seungjae Lee, Anang Shelat, Jay F. Sarthy, Michael P. Meers, Rani E. George, Elaine R. Mardis, Richard K. Wilson, Steven Henikoff, James R. Downing, Michael A. Dyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
Externí odkaz:
https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61
Autor:
Xiang Chen, Armita Bahrami, Alberto Pappo, John Easton, James Dalton, Erin Hedlund, David Ellison, Sheila Shurtleff, Gang Wu, Lei Wei, Matthew Parker, Michael Rusch, Panduka Nagahawatte, Jianrong Wu, Shenghua Mao, Kristy Boggs, Heather Mulder, Donald Yergeau, Charles Lu, Li Ding, Michael Edmonson, Chunxu Qu, Jianmin Wang, Yongjin Li, Fariba Navid, Najat C. Daw, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Jinghui Zhang, Michael A. Dyer
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 104-112 (2014)
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To define the landscape of somatic mutations in pediatric osteosarcoma, we performed whole-geno
Externí odkaz:
https://doaj.org/article/40f55a27461a4869b9e264b8b60dc172
Autor:
Noel-Marie Plonski, Cheng Chen, Qian Dong, Na Qin, Nan Song, Hemang M. Parikh, Kyla Shelton, Emily R. Finch, John Easton, Heather Mulder, Jinghui Zhang, Geoffrey Neale, Emily Walker, Hui Wang, Kevin Krull, Kirsten K. Ness, Melissa M. Hudson, Leslie L. Robison, Qian Li, AnnaLynn Williams, Zhaoming Wang
36 Importance: We previously demonstrated that some cancer therapies are strong risk factors for 37 epigenetic age acceleration (EAA) among childhood cancer survivors, and EAA is associated with chronic 38 health conditions (CHCs). However, these dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6784f7195f37dfe8db36085a13bc17