Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Heather M. Schellinck"'
Publikováno v:
Journal of Alzheimer's disease : JAD. 88(1)
Although Alzheimer’s disease is most often studied in terms of memory impairments, olfactory dysfunction begins in the early stages. We tested olfactory learning, sensitivity, and response bias using signal detection methods in 12-month-old male an
Publikováno v:
Chemical Senses. 41:433-440
Deficits in odor identification and detection are early symptoms of Alzheimer's disease (AD). Two transgenic mouse models of AD, the 5XFAD and the 3×Tg-AD mice and their wildtype controls, were assessed for olfactory detection with decreasing concen
Autor:
Heather M. Schellinck
Publikováno v:
Behavioural processes. 155
This paper briefly reviews the literature that describes olfactory acuity and odour discrimination learning. The results of current studies that examined the role of the neurotransmitters noradrenalin and acetylcholine in odour discrimination learnin
Publikováno v:
Alzheimer's & Dementia. 12
Autor:
Georgina Archbold, Diego Restrepo, Weihong Lin, Burton M. Slotnick, Heather M. Schellinck, Stephen R. Price
Publikováno v:
European Journal of Neuroscience. 31:1108-1116
Although it is now established that sensory neurons in both the main olfactory epithelium and the vomeronasal organ may be activated by both general and pheromonal odorants, it remains unclear what initiates sampling by the vomeronasal organ. Anterog
Publikováno v:
Behavioural Brain Research. 152:327-334
Polysialylated neural cell adhesion molecule (PSA-NCAM) is predominantly expressed during development where it regulates biological functions including axon targeting and neuronal precursor cell migration. Although dramatically down regulated after b
Publikováno v:
Behavioural Brain Research. 142:157-165
We assessed the long-term behavioural effects of a single acute or repetitive inflammatory pain experienced during infancy. Groups of male and female CD1 mice were subjected to either an acute single pain, i.e. a tail clip or sham pain at P8, or acut
Publikováno v:
Behavioural brain research. 270
While olfactory delayed matching-to-sample tasks have been used to assess working memory in rats, no such tasks have been tested in mice. Olfactory delayed matching-to-sample learning was assessed in male and female 5XFAD mice, a model of Alzheimer's
Publikováno v:
Chemical Senses. 26:663-672
The present paper describes a quick and efficient method for assessing olfactory discrimination learning in mice. In training mice received trials in which one odor (CS+) was paired with sugar and another odor (CS-) was paired with no sugar. When the