Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Heather M. Madsen"'
Autor:
Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, Sheri L. Bonar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57328f6e5ea96fc972d684f2e92281c
https://doi.org/10.1016/j.bmcl.2011.04.120
https://doi.org/10.1016/j.bmcl.2011.04.120
Autor:
Sarah E. Smith, Scott J. Bowen, Scott A. Long, David Beidler, Marvin J. Meyers, Atli Thorarensen, Heather M. Madsen, Joseph J. McDonald, Susan Foltin, Barbara A. Schweitzer, Tenbrink Ruth E, Jane L. Wang, Mark C. Walker, Matthew James Pelc
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH k(inact)/K(i) potency values greater than 1500M(-1)s(-1). The two novel spirocyclic cores, 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438967a60497c300b8da344350b5239
https://pubmed.ncbi.nlm.nih.gov/21924614
https://pubmed.ncbi.nlm.nih.gov/21924614
Autor:
Rajesh V. Devraj, Heather M. Madsen, Heidi M. Morgan, Laura D. Marrufo, Gary D. Anderson, Shaun R. Selness, Dean Messing, Elizabeth G. Webb, Joseph B. Monahan, Jian Zhang, Devadas Balekudru, Jerry Z. Yang, Huey S. Shieh, Li Xing
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(13)
A novel series of highly potent and selective p38 MAP kinase inhibitors was developed originating from a substituted N-aryl-6-pyrimidinone scaffold. SAR studies coupled with in vivo evaluations in rat arthritis model culminated in the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c50bfd334c3732636cf4d80aaa2300c
https://pubmed.ncbi.nlm.nih.gov/21620699
https://pubmed.ncbi.nlm.nih.gov/21620699
Autor:
Matthew James Pelc, Heather M. Madsen, Joseph J. McDonald, Scott J. Bowen, Barbara A. Schweitzer, David Beidler, Atli Thorarensen, Tenbrink Ruth E, Jane L. Wang
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
Fatty acid amide hydrolase (FAAH) has attracted significant attention due to its promise as an analgesic target. This has resulted in the discovery of numerous chemical classes as inhibitors of this potential therapeutic target. In this paper we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3e5e4475461d15a8771bc5fc71c1c6
https://pubmed.ncbi.nlm.nih.gov/19765986
https://pubmed.ncbi.nlm.nih.gov/19765986