Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heather M. Heerssen"'
Publikováno v:
The Journal of Neuroscience. 31:15026-15034
Synaptic connections can be stably maintained for prolonged periods, yet can be rapidly disassembled during the developmental refinement of neural circuitry and following cytological insults that lead to neurodegeneration. To date, the molecular mech
Autor:
Heather M. Heerssen, Christoph Karch, Fiona L. Watson, Michael E. Greenberg, Tae Kyung Kim, Rosalind A. Segal, Stephanie L. Courchesne, Maria F. Pazyra-Murphy, Aymeric Hans, Katharina E. Cosker
Publikováno v:
The Journal of Neuroscience. 29:6700-6709
Survival and maturation of dorsal root ganglia sensory neurons during development depend on target-derived neurotrophins. These target-derived signals must be transmitted across long distances to alter gene expression. Here, we address the possibilit
Autor:
Heather M. Heerssen, Rosalind A. Segal
Publikováno v:
Trends in Neurosciences. 25:160-165
Neurotrophins were originally identified as target-derived factors that regulate the survival and differentiation of innervating neurons. However, neurotrophins can also be released by presynaptic cells to stimulate postsynaptic neurons. Recent studi
Autor:
Daniel B. Moheban, Scott L. Pomeroy, Anita Bhattacharyya, Claire M. Sauvageot, Michael Z. Lin, Heather M. Heerssen, Rosalind A. Segal, Fiona L. Watson
Publikováno v:
The Journal of Neuroscience. 19:7889-7900
Target-derived neurotrophins initiate signals that begin at nerve terminals and cross long distances to reach the cell bodies and regulate gene expression. Neurotrophin receptors, Trks, themselves serve as retrograde signal carriers. However, it is n
Summary Background Among the most prominent molecular constituents of a recycling synaptic vesicle is the clathrin triskelion, composed of clathrin light chain (Clc) and clathrin heavy chain (Chc). Remarkably, it remains unknown whether clathrin is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45be3ef82cc314388416770e9447b782
https://europepmc.org/articles/PMC2699046/
https://europepmc.org/articles/PMC2699046/
Publikováno v:
Nature neuroscience. 7(6)
Mutations that alter dynein function are associated with neurodegenerative diseases, but it is not known why defects in dynein-dependent transport impair neuronal survival. Here we show that dynein function in axons is selectively required for the su
Autor:
Anita Bhattacharyya, Michael Z. Lin, Heather M. Heerssen, Rosalind A. Segal, Laura J. Klesse, Fiona L. Watson
Publikováno v:
Nature neuroscience. 4(10)
Growth factors synthesized and released by target tissues promote survival and differentiation of innervating neurons. This retrograde signal begins when growth factors bind receptors at nerve terminals. Activated receptors are then endocytosed and t
Autor:
Fiona L. Watson, Heather M. Heerssen, Anita Bhattacharyya, Laura Klesse, Michael Z. Lin, Rosalind A. Segal
Publikováno v:
Nature Neuroscience. 5:1017-1017