Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Heather M. Gransee"'
Autor:
Sepideh Jahanian, Miguel Pareja-Cajiao, Heather M. Gransee, Gary C. Sieck, Carlos B. Mantilla
Publikováno v:
Experimental Gerontology, Vol 194, Iss , Pp 112483- (2024)
Autophagy is a ubiquitous process through which damaged cytoplasmic structures are recycled and degraded within cells. Aging can affect autophagy regulation in different steps leading to the accumulation of damaged organelles and proteins, which can
Externí odkaz:
https://doaj.org/article/399e59a7720a422690c405e48ca43646
Autor:
Maria A. Gonzalez Porras, Heather M. Gransee, Travis T. Denton, Dunxin Shen, Kevin L. Webb, C. Jeffrey Brinker, Achraf Noureddine, Gary C. Sieck, Carlos B. Mantilla
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Impaired autophagy, a cellular digestion process that eliminates proteins and damaged organelles, has been implicated in neurodegenerative diseases, including motor neuron disorders. Motor neuron targeted upregulation of autophagy may serve
Externí odkaz:
https://doaj.org/article/619ee3b19e7e4d9793f0aae67eed638a
Autor:
Karim Azzag, Heather M. Gransee, Alessandro Magli, Aline M. S. Yamashita, Sudheer Tungtur, Aaron Ahlquist, Wen-Zhi Zhan, Chiemelie Onyebu, Sarah M. Greising, Carlos B. Mantilla, Rita C. R. Perlingeiro
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2503 (2024)
The diaphragm muscle is essential for breathing, and its dysfunctions can be fatal. Many disorders affect the diaphragm, including muscular dystrophies. Despite the clinical relevance of targeting the diaphragm, there have been few studies evaluating
Externí odkaz:
https://doaj.org/article/17c45b6794d542dca7f2ba7badd4c6c9
Autor:
Pangdra Vang, Amrit Vasdev, Wen‐Zhi Zhan, Heather M. Gransee, Gary C. Sieck, Carlos B. Mantilla
Publikováno v:
Physiological Reports, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Sarcopenia is the age‐related decline of skeletal muscle mass and function. Diaphragm muscle (DIAm) sarcopenia may contribute to respiratory complications, a common cause of morbidity and mortality in the elderly. From 6 to 24 months (mo)
Externí odkaz:
https://doaj.org/article/e40d8652eb3c42759b2c97c9d44df6a6
Autor:
Carlos B. Mantilla, Leonid G. Ermilov, Sarah M. Greising, Heather M. Gransee, Wen-Zhi Zhan, Gary C. Sieck
Publikováno v:
Journal of Neurophysiology. 129:781-792
Neurotrophin brain-derived neurotrophic factor (BDNF) enhances neuromuscular transmission via activation of tropomyosin-related kinase receptor B (TrkB). Rat phrenic nerve-diaphragm muscle preparations were used to determine the rapid effect of BDNF
Publikováno v:
J Neurophysiol
Unilateral C(2) hemisection (C(2)SH) disrupts descending inspiratory-related drive to phrenic motor neurons and thus, silences rhythmic diaphragm muscle (DIAm) activity. There is gradual recovery of rhythmic DIAm EMG activity over time post-C(2)SH, c
Publikováno v:
J Neurophysiol
Ventilatory deficits are common in old age and may result from neuromuscular dysfunction. Signaling via the tropomyosin-related kinase receptor B (TrkB) regulates neuromuscular transmission and, in young mice, is important for the generation of trans
Autor:
Heather M. Gransee, Maria A. Gonzalez Porras, Travis T. Denton, Dunxin Shen, Gary C. Sieck, Carlos B. Mantilla
Publikováno v:
The FASEB Journal. 36
Autor:
Emily C. Ducaji, Julie Sang, Miguel Pareja‐Cajiao, Heather M. Gransee, Gary C. Sieck, Carlos B. Mantilla
Publikováno v:
The FASEB Journal. 36
Autor:
Miguel Pareja‐Cajiao, Maria A. Barrera, Rachel A. Ducaji, Heather M. Gransee, Nathan J. Hellyer, Gary C. Sieck, Carlos B. Mantilla
Publikováno v:
The FASEB Journal. 36