Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Heather M Syred"'
Autor:
Judith Zich, Karen May, Konstantinos Paraskevopoulos, Onur Sen, Heather M Syred, Sjaak van der Sar, Hitesh Patel, James J Moresco, Ali Sarkeshik, John R Yates, Juri Rappsilber, Kevin G Hardwick
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1006009 (2016)
Externí odkaz:
https://doaj.org/article/e09d946afa2c43359a9576b99b1746b3
Autor:
Judith Zich, Karen May, Konstantinos Paraskevopoulos, Onur Sen, Heather M Syred, Sjaak van der Sar, Hitesh Patel, James J Moresco, Ali Sarkeshik, John R Yates, Juri Rappsilber, Kevin G Hardwick
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005834 (2016)
The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). M
Externí odkaz:
https://doaj.org/article/d8fbeccbac424c65aaf49c96458f0809
Autor:
Helen Kang, Juan Carlos Acosta, Xuejun Jiang, Noor Gammoh, Andrew J. Finch, Du Lam, Heather M. Syred, Jane Fraser, Eric C. Holland, Cindy Puente, Tatsuya Ozawa
Publikováno v:
Gammoh, N, Fraser, J, Puente, C, Syred, H M, Kang, H, Ozawa, T, Lam, D, Acosta, J C, Finch, A J, Holland, E & Jiang, X 2016, ' Suppression of autophagy impedes glioblastoma development and induces senescence ', Autophagy, vol. 12, no. 9, pp. 1431-1439 . https://doi.org/10.1080/15548627.2016.1190053
The function of macroautophagy/autophagy during tumor initiation or in established tumors can be highly distinct and context-dependent. To investigate the role of autophagy in gliomagenesis, we utilized a KRAS-driven glioblastoma mouse model in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bddfa1165822cdad54a263c486bd1ee
https://doi.org/10.1080/15548627.2016.1190053
https://doi.org/10.1080/15548627.2016.1190053
Autor:
Andrew J. Finch, Ioannis Kasioulis, Catherine H. Botting, Anne Seawright, Peri Tate, Veronica van Heyningen, Joseph Shaw, Sally L. Shirran, Matthew Fuszard, Patricia L. Yeyati, Ian R. Adams, Ian J. Jackson, Heather M. Syred
Publikováno v:
Kasioulis, I, Syred, H M, Tate, P, Finch, A, Shaw, J, Seawright, A, Fuszard, M, Botting, C H, Shirran, S, Adams, I R, Jackson, I J, Van Heyningen, V & Yeyati, P L 2014, ' Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis ', Molecular Biology of the Cell, vol. 25, no. 8, pp. 1216-1233 . https://doi.org/10.1091/mbc.E13-08-0471
Molecular Biology of the Cell
Molecular Biology of the Cell
Chromatin remodeling enzymes can also have nonhistone roles, broadening their biological functions. It is shown that Kdm3a binding to cellular chaperones in the cytoplasm is relevant for morphogenetic events leading to infertility in enzymatically nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef5f8251f9eb7ef680e108fd3289e22
https://doi.org/10.1091/mbc.e13-08-0471
https://doi.org/10.1091/mbc.e13-08-0471
Autor:
Judith Zich, Karen May, Konstantinos Paraskevopoulos, Onur Sen, Heather M Syred, Sjaak van der Sar, Hitesh Patel, James J Moresco, Ali Sarkeshik, John R Yates, Juri Rappsilber, Kevin G Hardwick
Publikováno v:
PLoS Genetics
Hardwick, K, Rappsilber, J, Van Der Sar, S, Syred, H M, Sen, O, Paraskevopoulos, K, May, K, Zich, J, Patel, H, Moresco, J J, Sarkeshik, A & Yates III, J R 2016, ' Mps1Mph1 kinase phosphorylates Mad3 to inhibit Cdc20Slp1-APC/C and maintain spindle checkpoint arrests ', PLoS Genetics, vol. 12, no. 2, e1005834 . https://doi.org/10.1371/journal.pgen.1005834
PLoS Genetics, Vol 12, Iss 2, p e1005834 (2016)
Hardwick, K, Rappsilber, J, Van Der Sar, S, Syred, H M, Sen, O, Paraskevopoulos, K, May, K, Zich, J, Patel, H, Moresco, J J, Sarkeshik, A & Yates III, J R 2016, ' Mps1Mph1 kinase phosphorylates Mad3 to inhibit Cdc20Slp1-APC/C and maintain spindle checkpoint arrests ', PLoS Genetics, vol. 12, no. 2, e1005834 . https://doi.org/10.1371/journal.pgen.1005834
PLoS Genetics, Vol 12, Iss 2, p e1005834 (2016)
The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d7c58fd48ac02009a322fec44e79355d
https://pubmed.ncbi.nlm.nih.gov/27101248
https://pubmed.ncbi.nlm.nih.gov/27101248
Publikováno v:
Molecular & Cellular Proteomics : MCP
Microtubules dramatically change their dynamics and organization at the entry into mitosis. Although this change is mediated by microtubule-associated proteins (MAPs), how MAPs themselves are regulated is not well understood. Here we used an integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5bb5070bea2b34d93dcd1d914d5434a
https://pubmed.ncbi.nlm.nih.gov/23893837
https://pubmed.ncbi.nlm.nih.gov/23893837
Autor:
Atlanta G. Cook, Kevin G. Hardwick, Juri Rappsilber, Laura Milne, Alicja M. Sochaj, Judith Zich, Heather M. Syred, Hiro Ohkura
Publikováno v:
Current Biology
Zich, J, Sochaj, A M, Syred, H M, Milne, L, Cook, A G, Ohkura, H, Rappsilber, J & Hardwick, K G 2012, ' Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex ', Current Biology, vol. 22, no. 4, pp. 296–301 . https://doi.org/10.1016/j.cub.2011.12.049
Zich, J, Sochaj, A M, Syred, H M, Milne, L, Cook, A G, Ohkura, H, Rappsilber, J & Hardwick, K G 2012, ' Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex ', Current Biology, vol. 22, no. 4, pp. 296–301 . https://doi.org/10.1016/j.cub.2011.12.049
Summary Defects in chromosome segregation result in aneuploidy, which can lead to disease or cell death [1, 2]. The spindle checkpoint delays anaphase onset until all chromosomes are attached to spindle microtubules in a bipolar fashion [3, 4]. Mad2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b422babab53da54d1e50ca17232280b