Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Heather M Raimer"'
Autor:
Nadine Michel, Heather M. Raimer Young, Naomi D. Atkin, Umar Arshad, Reem Al-Humadi, Sandeep Singh, Arkadi Manukyan, Lana Gore, Ian E. Burbulis, Yuh-Hwa Wang, Michael J. McConnell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Neurons are overproduced during cerebral cortical development. Neural progenitor cells (NPCs) divide rapidly and incur frequent DNA double-strand breaks (DSBs) throughout cortical neurogenesis. Although half of the neurons born during neurod
Externí odkaz:
https://doaj.org/article/afbddd025bee472c8522a305ded18559
Akademický článek
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Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background DNA double-stranded breaks (DSBs) are potentially deleterious events in a cell. The end structures (blunt, 3′- and 5′-overhangs) at DSB sites contribute to the fate of their repair and provide critical information concerning t
Externí odkaz:
https://doaj.org/article/043c9c61b7184bf08508b27b64fd45d4
Autor:
Michel, Nadine1,2 (AUTHOR), Young, Heather M. Raimer2 (AUTHOR), Atkin, Naomi D.2 (AUTHOR), Arshad, Umar2 (AUTHOR), Al-Humadi, Reem2 (AUTHOR), Singh, Sandeep2 (AUTHOR), Manukyan, Arkadi2 (AUTHOR), Gore, Lana3 (AUTHOR), Burbulis, Ian E.2,4 (AUTHOR), Wang, Yuh-Hwa2 (AUTHOR), McConnell, Michael J.3 (AUTHOR) mikemc@libd.org
Publikováno v:
Scientific Reports. 7/15/2022, Vol. 12 Issue 1, p1-14. 14p.
Autor:
Paweł Ł. Janczyk, Eliza Żyłkiewicz, Henry De Hoyos, Thomas West, Daniel R. Matson, Won-Chan Choi, Heather M. Raimer Young, Zygmunt S. Derewenda, P. Todd Stukenberg
Publikováno v:
Molecular Biology of the Cell. 34
Dynein inactivates the spindle assembly checkpoint (SAC) by transporting checkpoint proteins away from kinetochores toward spindle poles in a process known as "stripping." We find that inhibition of Aurora A kinase, which is localized to spindle pole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f47bfa91ecbdfc006b52a821be925c
https://doi.org/10.1091/mbc.e21-09-0438
https://doi.org/10.1091/mbc.e21-09-0438
Publikováno v:
Genes, Chromosomes and Cancer. 60:808-821
An initiating DNA double strand break (DSB) event precedes the formation of cancer-driven chromosomal abnormalities, such as gene rearrangements. Therefore, measuring DNA breaks at rearrangement-participating regions can provide a unique tool to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f459713c343ef04ad269d6e706e283
https://doi.org/10.1002/gcc.22993
https://doi.org/10.1002/gcc.22993
Autor:
Anita Salamon, Kirill S. Lobachev, Karol Szlachta, Heather M Raimer, Arkadi Manukyan, Yuh-Hwa Wang, Wenying Guo, Sandeep Singh
Publikováno v:
Nucleic Acids Research
DNA double-stranded breaks (DSBs) trigger human genome instability, therefore identifying what factors contribute to DSB induction is critical for our understanding of human disease etiology. Using an unbiased, genome-wide approach, we found that gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0144379b630550b75fa2922a13ab3b8
http://europepmc.org/articles/PMC7337936
http://europepmc.org/articles/PMC7337936
Autor:
Philip J. Smaldino, Amy Krans, Yi-Ju Tseng, Yuh-Hwa Wang, Adam E. Richardson, Katelyn M. Green, James P. Vaughn, Meredith E. Sharlow, Eric D. Routh, Peter K. Todd, Melissa A. Smaldino, Siara N. Sandwith, Antonio E. Chambers, Michael A. Reisinger, Heather M Raimer
Publikováno v:
The Journal of Biological Chemistry
GGGGCC (G4C2) hexanucleotide repeat expansions in the endosomal trafficking gene C9orf72 are the most common genetic cause of ALS and frontotemporal dementia. Repeat-associated non-AUG (RAN) translation of this expansion through near-cognate initiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3ff8599557e7269f89d5bb5b0f3c3c
http://europepmc.org/articles/PMC8326427
http://europepmc.org/articles/PMC8326427
Autor:
Katelyn M. Green, Melissa A. Smaldino, Peter K. Todd, Amy Krans, Meredith E. Sharlow, Michael A. Reisinger, Antonio E. Chambers, Yi-Ju Tseng, Yuh-Hwa Wang, Heather M Raimer, Siara N. Sandwith, Eric D. Routh, Philip J. Smaldino, James P. Vaughn, Adam E. Richardson
GGGGCC (G4C2) hexanucleotide repeat expansions (HRE) in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG (RAN) translation of this expansion generates toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1356fcf6b9169f89aae2d66393fd98f
https://doi.org/10.1101/2021.04.25.441260
https://doi.org/10.1101/2021.04.25.441260
Autor:
Stefan Bekiranov, Arkadi Manukyan, Sandeep Singh, Yuh-Hwa Wang, Karol Szlachta, Heather M Raimer, Manikarna Dinda
Publikováno v:
J Biol Chem
DNA double-stranded breaks (DSBs) are strongly associated with active transcription, and promoter-proximal pausing of RNA polymerase II (Pol II) is a critical step in transcriptional regulation. Mapping the distribution of DSBs along actively express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7865dc6de0ba638ef1aaf0837ccd81d
https://europepmc.org/articles/PMC7086017/
https://europepmc.org/articles/PMC7086017/