Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Heather M O'Hagan"'
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0313769 (2024)
Epithelial-to-mesenchymal (EMT) transition is one of the best-known examples of tumor cell plasticity. EMT enhances cancer cell metastasis, which is the main cause of colorectal cancer (CRC)-related mortality. Therefore, understanding underlying mole
Externí odkaz:
https://doaj.org/article/eb270a837cdb4fb09ec914bb4aded435
Autor:
Shruthi Sriramkumar, Tara X Metcalfe, Tim Lai, Xingyue Zong, Fang Fang, Heather M O'Hagan, Kenneth P Nephew
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0271584 (2022)
Ovarian cancer (OC) is a lethal gynecological malignancy with a five-year survival rate of only 46%. Development of resistance to platinum-based chemotherapy is a common cause of high mortality rates among OC patients. Tumor and transcriptomic hetero
Externí odkaz:
https://doaj.org/article/24b51e4e96a748f1b856bef82aac4f3c
Autor:
Jae-Hyeok Kang, Nizam Uddin, Seungmo Kim, Yi Zhao, Ki-Chun Yoo, Min-Jung Kim, Sung-Ah Hong, Sangsu Bae, Jeong-Yeon Lee, Incheol Shin, Young Woo Jin, Heather M. O’Hagan, Joo Mi Yi, Su-Jae Lee
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Triple-negative breast cancer (TNBC), the most aggressive subtype, presents a critical challenge due to the absence of approved targeted therapies. Hence, there is an urgent need to identify effective therapeutic targets for this condition.
Externí odkaz:
https://doaj.org/article/6c5a1e8d71c14b51abf556d24cb132c7
Publikováno v:
PLoS Genetics, Vol 4, Iss 8, p e1000155 (2008)
Chronic exposure to inducers of DNA base oxidation and single and double strand breaks contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage, such tumors often contain epigenetically silenced genes with aberrant pr
Externí odkaz:
https://doaj.org/article/56ccb0a21b204080a9192dc0cb52e225
Autor:
Ahmed H. Ghobashi, Truc T. Vuong, Jane W. Kimani, Christopher A. Ladaika, Peter C. Hollenhorst, Heather M. O’Hagan
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107630- (2023)
Summary: Colorectal cancer (CRC) develops in part through the deregulation of different signaling pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally, the lysine methyltransferase enhancer of zeste homologue 2 (EZ
Externí odkaz:
https://doaj.org/article/8c89486deec245ebab43998162055371
Autor:
Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew, Heather M. O’Hagan
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is u
Externí odkaz:
https://doaj.org/article/85d7608e424a4ee082a8b2bdd7825bec
Publikováno v:
Epigenetics, Vol 14, Iss 12, Pp 1209-1223 (2019)
Chronic inflammation is strongly associated with an increased risk of developing colorectal cancer. DNA hypermethylation of CpG islands alters the expression of genes in cancer cells and plays an important role in carcinogenesis. Chronic inflammation
Externí odkaz:
https://doaj.org/article/2bf073048d954c348f2a2b9a572917e0
Autor:
Heather M. O'Hagan, John J. Turchi, Kenneth P. Nephew, Katherine S. Pawelczak, Pamela S. VanderVere-Carozza, Samuel A. Miller, Ahmed H. Ghobashi, Timothy D. Matthews, Shruthi Sriramkumar
RPA inhibition reduces RING1A localization to sites of cisplatin-induced DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b041054b6f93fc455c2155e4854fa6
https://doi.org/10.1158/1541-7786.22526583.v1
https://doi.org/10.1158/1541-7786.22526583.v1
Autor:
Heather M. O'Hagan, Gabriel E. Zentner, Philip A. Cole, Jay H. Kalin, Sha Cao, Helai P. Mohammad, Xiaoyu Lu, Ning Ding, Shruthi Sriramkumar, Sudha S. Savant, Robert A. Policastro, Samuel A. Miller
Supplementary Table S1: Mutational status of common oncogenes in CRC and STAD cell lines. Supplementary Figure S1: Mutant PIK3CA does not regulate LSD1 expression. Supplementary Figure S2: DNase signal is not generally depleted at TSS's, and LSD1 doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f941c62abdac958080c3361122a6fbc
https://doi.org/10.1158/1541-7786.22516900
https://doi.org/10.1158/1541-7786.22516900
Autor:
Heather M. O'Hagan, Gabriel E. Zentner, Philip A. Cole, Jay H. Kalin, Sha Cao, Helai P. Mohammad, Xiaoyu Lu, Ning Ding, Shruthi Sriramkumar, Sudha S. Savant, Robert A. Policastro, Samuel A. Miller
Activation of the epithelial-to-mesenchymal transition (EMT) program is a critical mechanism for initiating cancer progression and migration. Colorectal cancers contain many genetic and epigenetic alterations that can contribute to EMT. Mutations act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7928fb146a73ac07f46fae05ff391c9
https://doi.org/10.1158/1541-7786.c.6541534
https://doi.org/10.1158/1541-7786.c.6541534