Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Heather M Froggatt"'
Autor:
Heather M Froggatt, Kaitlyn N Burke, Ryan R Chaparian, Hector A Miranda, Xinyu Zhu, Benjamin S Chambers, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009951 (2021)
Influenza A viruses encode their genomes across eight, negative sense RNA segments. The six largest segments produce mRNA transcripts that do not generally splice; however, the two smallest segments are actively spliced to produce the essential viral
Externí odkaz:
https://doaj.org/article/5f9db5129dae43e99d5e7c7d6e8b2e01
Publikováno v:
FEBS J
The productive replication of human influenza viruses is almost exclusively restricted to cells in the respiratory tract. However, a key aspect of the host response to viral infection is the production of inflammatory cytokines and chemokines that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538b5e1819b57cd05e68968b5dab474e
https://doi.org/10.1111/febs.16363
https://doi.org/10.1111/febs.16363
Autor:
Brooke Schuster, Mason R Firpo, Dominique Missiakas, Susan Baker, Hyun Lee, Jennifer K. DeMarco, Marco Vignuzzi, Krysten A. Jones, Bjoern Meyer, Vishnu Nair, Robert Jedrzejczak, Savaş Tay, Bryan C. Dickinson, Jason Botten, Emily A. Bruce, Vincent Mastrodomenico, Amornrat O'Brien, Kenneth E. Palmer, Madaline M. Schmidt, Bryan C. Mounce, Nir Drayman, Christopher B. Brooke, Nicholas S. Heaton, Natalia Maltseva, Saara-Anne Azizi, Glenn Randall, Heather M. Froggatt, Andrzej Joachimiak, Siquan Chen, Rahul S. Kathayat, Steve Dvorkin, Anastasia Tomatsidou, Miguel Ángel Muñoz-Alía, William E. Severson, Kevin Furlong, Vlad Nicolaescu, Kemin Tan, Kyu-yeon Han
Publikováno v:
bioRxiv
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest path to clinical use is repurposing of drugs that have an established safety profile in humans. Here, we first screened a library of 1,900 clinically safe dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d54f7b1f5ec0a952b5543913632dda0
https://doi.org/10.1126/science.abg5827
https://doi.org/10.1126/science.abg5827
Publikováno v:
Science
GPER1 in utero to the rescue! Several common pathogens, including influenza A virus (IAV), can activate systemic type I interferon (IFN) signaling during pregnancy. Such infections would be expected to cause birth defects and fetal mortality, but mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef454472f85452a55d12de70a101e609
https://doi.org/10.1126/science.aba9001
https://doi.org/10.1126/science.aba9001
Publikováno v:
Sci Signal
The type I interferon (IFN) response is an important component of the innate immune response to viral infection. Precise control of IFN responses is critical because insufficient expression of IFN-stimulated genes (ISGs) can lead to a failure to rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5823b06d2693417764ab9ffa886cf42d
https://doi.org/10.1126/scisignal.abe1194
https://doi.org/10.1126/scisignal.abe1194
Publikováno v:
Journal of Virology
In late 2019, a human coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, likely from a zoonotic reservoir. This virus causes COVID-19, has infected millions of people, and has led to hundreds of thousands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7c8f5e2819975fa9eb6273255ab37d
Autor:
Brooke Schuster, Vishnu Nair, Jason Botten, Susan C. Baker, Bryan C. Mounce, Kemin Tan, Mason R Firpo, Savaş Tay, Madaline M. Schmidt, Heather M. Froggatt, Emily A. Bruce, Nir Drayman, Siquan Chen, Sarra-Anne Azizi, Steve Dvorkin, Kevin Furlong, Krysten A. Jones, Glenn Randall, Vlad Nicolaescu, Nicholas S. Heaton, Bryan C. Dickinson, Natalia Maltseva, Rahul S. Kathayat, Christopher B. Brooke, Miguel Ángel Muñoz-Alía, Andrzej Jaochimiak, Vincent Mastrodomenico, Robert Jedrzejczak
Publikováno v:
Science
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest path to clinical use is repurposing of drugs that have an established safety profile in humans. Here, we first screened a library of 1,900 clinically safe dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ddfda4f670d92e5c0ff15b956476b7
https://pubmed.ncbi.nlm.nih.gov/34285133
https://pubmed.ncbi.nlm.nih.gov/34285133
In late 2019 a human coronavirus, now known as SARS-CoV-2, emerged, likely from a zoonotic reservoir. This virus causes COVID-19 disease, has infected millions of people, and has led to hundreds of thousands of deaths across the globe. While the best
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e308e403092336f5b91b7e84c0102654
https://doi.org/10.1101/2020.06.24.169565
https://doi.org/10.1101/2020.06.24.169565
Publikováno v:
Journal of Virology
The COVID-19 pandemic has already led to more than 700,000 deaths and innumerable changes to daily life worldwide. Along with development of a vaccine, identification of effective antivirals to treat infected patients is of the highest importance. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::344d535dcbd91f66c3b8ec1f3327b4d3
https://pubmed.ncbi.nlm.nih.gov/32843534
https://pubmed.ncbi.nlm.nih.gov/32843534
Autor:
Xinyu Zhu, Hector A. Miranda, Benjamin S. Chambers, Heather M. Froggatt, Ryan R. Chaparian, Nicholas S. Heaton, Kaitlyn N. Burke
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009951 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009951 (2021)
Influenza A viruses encode their genomes across eight, negative sense RNA segments. The six largest segments produce mRNA transcripts that do not generally splice; however, the two smallest segments are actively spliced to produce the essential viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f94f5fdacecb7b40645c647faaf7afa
https://doi.org/10.1371/journal.ppat.1009951
https://doi.org/10.1371/journal.ppat.1009951