Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Heather M, Wallace"'
Improved strategies to counter the COVID-19 pandemic: Lockdowns vs. primary and community healthcare
Autor:
Konstantinos Farsalinos, Konstantinos Poulas, Dimitrios Kouretas, Apostolos Vantarakis, Michalis Leotsinidis, Dimitrios Kouvelas, Anca Oana Docea, Ronald Kostoff, Grigorios T. Gerotziafas, Michael N. Antoniou, Riccardo Polosa, Anastastia Barbouni, Vassiliki Yiakoumaki, Theodoros V. Giannouchos, Pantelis G. Bagos, George Lazopoulos, Boris N. Izotov, Victor A. Tutelyan, Michael Aschner, Thomas Hartung, Heather M. Wallace, Félix Carvalho, Jose L. Domingo, Aristides Tsatsakis
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 1-9 (2021)
COVID-19 pandemic mitigation strategies are mainly based on social distancing measures and healthcare system reinforcement. However, many countries in Europe and elsewhere implemented strict, horizontal lockdowns because of extensive viral spread in
Externí odkaz:
https://doaj.org/article/f4792fabd3904a5eb21b2c47ad43692c
Autor:
Oluwaseun Akinyele, Heather M. Wallace
Publikováno v:
Medical Sciences, Vol 10, Iss 3, p 51 (2022)
The polyamines putrescine, spermidine and spermine are nutrient-like polycationic molecules involved in metabolic processes and signaling pathways linked to cell growth and cancer. One important pathway is the PI3K/Akt pathway where studies have show
Externí odkaz:
https://doaj.org/article/661599cef1264b029cce6298ac9ae079
Autor:
Michael Aschner, Monica M.B. Paoliello, Jose L. Domingo, Demetrios A. Spandidos, Angela Mally, Heather M Wallace, Valerii N. Rakitskii, Thomas Hartung, Aristides Tsatsakis
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 1607- (2020)
Externí odkaz:
https://doaj.org/article/a5cc3864741b4e6abc5977bed5769006
Autor:
EFSA Scientific Committee, Simon J More, Vasileios Bampidis, Diane Benford, Claude Bragard, Thorhallur I Halldorsson, Antonio F Hernández‐Jerez, Susanne Hougaard Bennekou, Kostas P Koutsoumanis, Kyriaki Machera, Hanspeter Naegeli, Søren S Nielsen, Josef R Schlatter, Dieter Schrenk, Vittorio Silano, Dominique Turck, Maged Younes, Ursula Gundert‐Remy, George E N Kass, Juliane Kleiner, Anna Maria Rossi, Rositsa Serafimova, Linda Reilly, Heather M Wallace
Publikováno v:
EFSA Journal, Vol 17, Iss 6, Pp n/a-n/a (2019)
Abstract The Scientific Committee confirms that the Threshold of Toxicological Concern (TTC) is a pragmatic screening and prioritisation tool for use in food safety assessment. This Guidance provides clear step‐by‐step instructions for use of the
Externí odkaz:
https://doaj.org/article/225b40c36dbb4d8d859c557d35dea98b
Autor:
Oluwaseun Akinyele, Heather M. Wallace
Publikováno v:
Biomolecules, Vol 11, Iss 5, p 743 (2021)
Breast cancer is a complex heterogeneous disease with multiple underlying causes. The polyamines putrescine, spermidine, and spermine are polycationic molecules essential for cell proliferation. Their biosynthesis is upregulated in breast cancer and
Externí odkaz:
https://doaj.org/article/f0b037bf2eb64eaaac07393dfed19ccf
Autor:
Misael Corral, Heather M. Wallace
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 499 (2020)
Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells. Polyamine transport also contributes to the
Externí odkaz:
https://doaj.org/article/163262b87bf74456b9c6bd287f80866f
Improved strategies to counter the COVID-19 pandemic: Lockdowns vs. primary and community healthcare
Autor:
Heather M. Wallace, Victor A. Tutelyan, Riccardo Polosa, José L. Domingo, Pantelis G. Bagos, Ronald N. Kostoff, Anastastia Barbouni, George Lazopoulos, Félix Carvalho, Dimitrios Kouvelas, Izotov Bn, Vassiliki Yiakoumaki, Konstantinos Poulas, Theodoros V. Giannouchos, Apostolos Vantarakis, Michalis Leotsinidis, Michael Aschner, Konstantinos Farsalinos, Aristides M. Tsatsakis, Grigorios T. Gerotziafas, Anca Oana Docea, Thomas Hartung, Michael Antoniou, Dimitrios Kouretas
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1-9 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • The COVID-19 pandemic has challenged the healthcare capacity of many countries. • Strict, horizontal lockdowns have adverse social, economic and health effects that have not been fully considered. • Primary
Highlights • The COVID-19 pandemic has challenged the healthcare capacity of many countries. • Strict, horizontal lockdowns have adverse social, economic and health effects that have not been fully considered. • Primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c115b04e38a9a5b21f214379cfeb8ed
https://doi.org/10.1016/j.toxrep.2020.12.001
https://doi.org/10.1016/j.toxrep.2020.12.001
Autor:
Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4614
The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). OAZ1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce39be386fe80d10da9fb9252770da08
https://pubmed.ncbi.nlm.nih.gov/35563006
https://pubmed.ncbi.nlm.nih.gov/35563006
Publikováno v:
Toxicology Letters. 302:28-34
Increasing evidence shows that discrepancies exist among in vitro cytotoxicity methods resulting in unreliable drug toxicity profiles. This is particularly criticial for cell lines such as gliomas which are histologically and genetically heterogeneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c8223d01bd5bd0ae779e2c95618546
https://doi.org/10.1016/j.toxlet.2018.12.004
https://doi.org/10.1016/j.toxlet.2018.12.004
Publikováno v:
Biochemical Journal. 476:245-259
Glioblastoma (GB) represents the most common and aggressive form of malignant primary brain tumour associated with high rates of morbidity and mortality. In the present study, we considered the potential use of idebenone (IDE), a Coenzyme Q10 analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ef8259ab3cf075cc9b3c4b4042ff3e
https://doi.org/10.1042/bcj20180384
https://doi.org/10.1042/bcj20180384