Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Heather M, Murray"'
Autor:
Sheri L. Booten, Gustavo Buchele, Mariam Aghajan, Todd Machemer, Brett P. Monia, Richard S. Geary, Nicholas J. Viney, Sue Murray, Merrill D. Benson, Sebastien A. Burel, Sotirios Tsimikas, Shuling Guo, Eugene Schneider, Shiangtung W. Jung, Brenda F. Baker, Heather M. Murray, Li-Jung Tai, Rosie Z. Yu
Publikováno v:
ESC heart failure, vol 8, iss 1
ESC Heart Failure, Vol 8, Iss 1, Pp 652-661 (2021)
ESC Heart Failure
ESC Heart Failure, Vol 8, Iss 1, Pp 652-661 (2021)
ESC Heart Failure
AimsAmyloidogenic transthyretin (ATTR) amyloidosis is a fatal disease characterized by progressive cardiomyopathy and/or polyneuropathy. AKCEA-TTR-LRx (ION-682884) is a ligand-conjugated antisense drug designed for receptor-mediated uptake by hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff308bcce12264c19717432639a3fe9f
https://escholarship.org/uc/item/41n576q7
https://escholarship.org/uc/item/41n576q7
Autor:
Naveed Sattar, Heather M Murray, Paul Welsh, Gerard J Blauw, Brendan M Buckley, Stuart Cobbe, Anton J M de Craen, Gordon D Lowe, J Wouter Jukema, Peter W Macfarlane, Michael B Murphy, David J Stott, Rudi G J Westendorp, James Shepherd, Ian Ford, Chris J Packard, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Study Group
Publikováno v:
PLoS Medicine, Vol 6, Iss 6, p e1000099 (2009)
BACKGROUND: Circulating inflammatory markers may more strongly relate to risk of fatal versus nonfatal cardiovascular disease (CVD) events, but robust prospective evidence is lacking. We tested whether interleukin (IL)-6, C-reactive protein (CRP), an
Externí odkaz:
https://doaj.org/article/0d733b123362413581963ddbd615e44f
Autor:
Sheri L. Booten, W. Brad Wan, Guillermo Vasquez, Susan F. Murray, Audrey Low, Punit P. Seth, Thazha P. Prakash, Heather M. Murray, Alfred E. Chappell, Jeff Crosby, Sebastien A. Burel, Todd Machemer, Armand Soriano, Hans Gaus, Michael T. Migawa, Patrick Cauntay, Jill Hsiao, Jinghua Yu, Mark J. Graham, Recaldo L. Carty, Mariam Aghajan, Michael E. Østergaard, Garth A. Kinberger, Karsten Schmidt, Eric E. Swayze
Publikováno v:
Journal of Medicinal Chemistry. 59:2718-2733
The comprehensive structure-activity relationships of triantennary GalNAc conjugated ASOs for enhancing potency via ASGR mediated delivery to hepatocytes is reported. Seventeen GalNAc clusters were assembled from six distinct scaffolds and attached t
Autor:
Guillermo Vasquez, Heather M. Murray, Walt F. Lima, Andres Berdeja, Eric E. Swayze, W. Brad Wan, Hans Gaus, Josh G. Nichols, Punit P. Seth, Christopher E. Hart, Michael T. Migawa, Sam Lee
Publikováno v:
Nucleic Acids Research
Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)-modified gapmer antisense oligonucleotides (ASOs) with control of the chirality of each of the PS linkages within the 10-base gap. The stereoselectivity was d
Autor:
Walt F. Lima, Edward Wancewicz, Eric E. Swayze, Punit P. Seth, Melanie Bell, Aaron J. Donner, Heather M. Murray, Sarah Greenlee, Noah Post
Publikováno v:
Nucleic acid therapeutics. 27(4)
Phosphorothioate (PS) modified antisense oligonucleotides (ASOs) have progressed rapidly in the clinic for treating a variety of disease indications. We previously demonstrated that the activity of PS ASOs in the liver can be enhanced by co-infusion
Autor:
Alfred E. Chappell, Jinghua Yu, Audrey Low, Hans Gaus, Heather M. Murray, Karsten Schmidt, Eric E. Swayze, Punit P. Seth, Garth A. Kinberger, Thazha P. Prakash, Guillermo Vasquez
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
Antisense oligonucleotides (ASOs) conjugated to trivalent GalNAc ligands show 10-fold enhanced potency for suppressing gene targets expressed in hepatocytes. Trivalent GalNAc is a high affinity ligand for the asialoglycoprotein receptor (ASGR)-a C-ty
Autor:
Walt F. Lima, Sagar S. Damle, Cheryl L De Hoyos, Heather M. Murray, Christopher E. Hart, Xue-hai Liang, Stanley T. Crooke, Gene Hung
Publikováno v:
Nucleic Acids Research
Viable constitutive and tamoxifen inducible liver-specific RNase H1 knockout mice that expressed no RNase H1 activity in hepatocytes showed increased R-loop levels and reduced mitochondrial encoded DNA and mRNA levels, suggesting impaired mitochondri
Autor:
Garth A. Kinberger, Mark J. Graham, Punit P. Seth, Eric E. Swayze, Walt F. Lima, Heather M. Murray, Alfred E. Chappell, Thazha P. Prakash, Stan Riney
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(12)
Chemical modifications are essential to improve metabolic stability and pharmacokinetic properties of siRNA to enable their systemic delivery. We investigated the effect of combing the phosphorothioate (PS) modification with metabolically stable phos
Autor:
Hans Gaus, Hong Sun, Walt F. Lima, Heather M. Murray, Andres Berdeja, Stanley T. Crooke, Thazha P. Prakash, Josh G. Nichols, Hongjiang Wu
Publikováno v:
Journal of Biological Chemistry. 284:2535-2548
Human Dicer is an integral component of the RNA interference pathway. Dicer processes premicro-RNA and double-strand RNA to, respectively, mature micro-RNA and short interfering RNA (siRNA) and transfers the processed products to the RNA-induced sile
Autor:
Hans Gaus, Garth A. Kinberger, Punit P. Seth, Audrey Low, Guillermo Vasquez, Jinghua Yu, Michael E. Østergaard, Karsten Schmidt, Eric E. Swayze, Michael T. Migawa, W. Brad Wan, Heather M. Murray, Thazha P. Prakash
Publikováno v:
Bioconjugate chemistry. 26(8)
Conjugation of triantennary N-acetyl galactosamine (GalNAc) to oligonucleotide therapeutics results in marked improvement in potency for reducing gene targets expressed in hepatocytes. In this report we describe a robust and efficient solution-phase