Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heather L. McFarland"'
Autor:
David J. Willock, Natasha M. Galea, Heather L. McFarland, Colin M. Hayman, Philip C. Bulman Page
Publikováno v:
Synlett. 2002:0583-0587
A synthesis of the tricyclic ring system of the daphnane and tigliane diterpenes, incorporating C-18 and the C-13 oxygen functionality found in phorbol and related compounds is described. The convergent synthesis utilizes an intramolecular Diels-Alde
Autor:
Peter Ballard, Michael James, Daniel S. James, Peter D. Smith, Simon J. Brown, M. Raymond V. Finlay, Michael J. Waring, Paula Perkins, Andrew D. Campbell, Heather L. McFarland, David Perkins, Gordon S. Currie, Gillian M. Lamont, Graham Richmond, Matthew R. Box, David Whittaker, Mark J. Anderton, Richard A. Ward, Teresa Klinowska, Scott G. Lamont, Nicola Colclough, Stuart L. Wells, Darren Cross, Gail L. Wrigley, George B. Hill, Nathaniel G. Martin, Paul D. Kemmitt, Susan Ashton, Lorraine A. Hassall, Paul A. Bethel, Robert Hugh Bradbury, Sam Butterworth, Christopher G. Chorley, Martine J. Mellor, Matthew Grist, Jonathon P. Orme
Publikováno v:
Journal of medicinal chemistry. 57(20)
Epidermal growth factor receptor (EGFR) inhibitors have been used clinically in the treatment of non-small-cell lung cancer (NSCLC) patients harboring sensitizing (or activating) mutations for a number of years. Despite encouraging clinical efficacy
Publikováno v:
Tetrahedron Letters. 38:6913-6916
A synthesis of the tetracyclic ring system of phorbol and other tigliane diterpenes has been achieved in six steps using an unusual intramolecular Diels-Alder reaction both as the key stereocontrolling process and to introduce a double bond appropria
Autor:
Joanne Wilson, J. Matthew Wood, A. Nigel Brooks, Hill Kathryn Jane, Alfred A. Rabow, Graeme Walker, Andrew G. Thomason, Barry R. Hayter, Nicholas J. Howe, Stuart L. Wells, Glenn Hatter, David A. Jude, Sarah A. Loddick, Gorkhn Sharma-Singh, Scott G. Lamont, Heather L. McFarland, Dawn Trueman, Natalie Stratton, Zaieda Parveen, Nicola Broadbent, Carr Gregory Richard, David G. Acton, Robert Hugh Bradbury, Rhys D.O. Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the triazolopyridazine moiety in the previously-described lead androgen receptor downregulator 6-[4-(4-cyanobenzyl)piperazin-1-yl]-3-(tri
Publikováno v:
ChemInform. 28
A synthesis of the tetracyclic ring system of phorbol and other tigliane diterpenes has been achieved in six steps using an unusual intramolecular Diels-Alder reaction both as the key stereocontrolling process and to introduce a double bond appropria
Autor:
Nicola Colclough, Mark J. Anderton, Martine J. Mellor, Rob H. Bradbury, Heather L. McFarland, Richard A. Ward, Sam Butterworth, M Ray V. Finlay, Darren Cross, Pete G. Ballard, Michael J. Waring, Susan Ashton
Publikováno v:
Cancer Research. 74:4744-4744
Small molecule inhibitors of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase such as gefitinib and erlotinib have been employed successfully in the treatment of non-small cell lung cancer (NSCLC) patients harboring an activating mutation
Autor:
Heather L. McFarland, Peter Ballard, Claudio Chuaqui, Susan Ashton, M. Raymond V. Finlay, Sam Butterworth, Martine J. Mellor, Darren Cross, Nicola Colclough, Rob H. Bradbury, Richard A. Ward, Mark J. Anderton, Michael J. Waring
Publikováno v:
Molecular Cancer Therapeutics. 12:B94-B94
Small molecule inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase such as gefitinib and erlotinib have been employed successfully in the treatment of non-small cell lung cancer (NSCLC) patients harboring an activating mutation