Výsledky vyhledávání - "Heather L. Martin"

Akademický článek

Affimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles

Autor: Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson

Publikováno v: iScience, Vol 27, Iss 8, Pp 110461- (2024)

Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric

Externí odkaz: https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47

Zobrazit plný text záznamu

Akademický článek

Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition

Autor: Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson

Publikováno v: Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)

Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing

Externí odkaz: https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6

Zobrazit plný text záznamu

Akademický článek

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools

Externí odkaz: https://doaj.org/article/9fb0e318fb534431a1e30f0ac4d27ca1

Zobrazit plný text záznamu

Akademický článek

In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin

Autor: Matteo Santoro, Walter Maetzler, Petros Stathakos, Heather L. Martin, Markus A. Hobert, Tim W. Rattay, Thomas Gasser, John V. Forrester, Daniela Berg, Kevin J. Tracey, Gernot Riedel, Peter Teismann

Publikováno v: Neurobiology of Disease, Vol 91, Iss , Pp 59-68 (2016)

High-mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that is released during tissue damage from immune and non-immune cells — including microglia and neurons. HMGB1 can contribute to progression of numerous chronic inflammatory and

Externí odkaz: https://doaj.org/article/4abb6cad582648929eac5ff3eeb821c5

Zobrazit plný text záznamu

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
'Nature Communications ', vol: 12, pages: 4045-1-4045-15 (2021)
Nature Communications

RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable pockets have proven difficult to identify. Here, we identify two RAS-binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7c3a7099793492e3c58ab8d5138de3
https://doaj.org/article/9fb0e318fb534431a1e30f0ac4d27ca1

Zobrazit plný text záznamu

Akademický článek

High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers.

Autor: Heather L Martin, Matthew Adams, Julie Higgins, Jacquelyn Bond, Ewan E Morrison, Sandra M Bell, Stuart Warriner, Adam Nelson, Darren C Tomlinson

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88338 (2014)

Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The us

Externí odkaz: https://doaj.org/article/662c944ba0d54a6e9808ab389a227357

Zobrazit plný text záznamu

Abstract B24: Development of small-molecule RAS inhibitors using Affimer reagents

Autor: Holly Foster, Rachel Trowbridge, Alexander L. Breeze, Katarzyna Z. Haza, Kevin W. Tipping, Richard Foster, Thomas A. Edwards, Heather L. Martin, Michael J. McPherson, Darren C. Tomlinson, Christian Tiede, Chi Trinh

Publikováno v: Molecular Cancer Research. 18:B24-B24

Ras proteins are small GTPases that are mutationally activated in around 30% of all human cancers. Oncogenic mutations in Ras trigger uncontrolled cellular differentiation and division through uninhibited Ras-GTP signaling. Despite major efforts in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ef1ea7ab65b882fb43ac7191e63b6bf
https://doi.org/10.1158/1557-3125.ras18-b24

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání