Výsledky vyhledávání - "Heather L. Howie"

Akademický článek

Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice

Autor: Angelo D’Alessandro, Heather L. Howie, Ariel M. Hay, Karolina H. Dziewulska, Benjamin C. Brown, Matthew J. Wither, Matthew Karafin, Elizabeth F. Stone, Steven L. Spitalnik, Eldad A. Hod, Richard O. Francis, Xiaoyun Fu, Tiffany Thomas, James C. Zimring

Publikováno v: JCI Insight, Vol 6, Iss 14 (2021)

Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (approximately 5%). Its prevalence is hypothesized to be due to conferring resistance to malaria. However, G6PD

Externí odkaz: https://doaj.org/article/4e5a19c76334443c86760cff369b5572

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Akademický článek

Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice

Autor: Heather L. Howie, Ariel M. Hay, Karen de Wolski, Hayley Waterman, Jenna Lebedev, Xiaoyun Fu, Rachel Culp-Hill, Angelo D'Alessandro, James D. Gorham, Matthew S. Ranson, John D. Roback, Peter C. Thomson, James C. Zimring

Publikováno v: Blood Advances, Vol 3, Iss 15, Pp 2272-2285 (2019)

Abstract: Red blood cells (RBCs) are the most numerous cell type in the body and serve a vital purpose of delivering oxygen to essentially all tissues. In addition to the central role of RBCs in health and disease, RBC storage is a requirement for th

Externí odkaz: https://doaj.org/article/af97ca379a834d02bbdaa7b73bbe84ad

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Akademický článek

Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice

Autor: Arijita Jash, Chomkan Usaneerungrueng, Heather L. Howie, Annie Qiu, Chance John Luckey, James C. Zimring, Krystalyn E. Hudson

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Red blood cells expressing alloantigens are well known to be capable of inducing robust humoral alloantibody responses both in transfusion and pregnancy. However, the majority of transfusion recipients and pregnant women never make alloantibodies, ev

Externí odkaz: https://doaj.org/article/e83375f4a15647e8989d97fb982d5cc4

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Akademický článek

IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice

Autor: Paurvi Shinde, Heather L. Howie, Tamara C. Stegmann, Ariel M. Hay, Hayley R. Waterman, Zoltan Szittner, Arthur E. H. Bentlage, Linda Kapp, Suzanne N. Lissenberg-Thunnissen, Gillian Dekkers, Richard B. M. Schasfoort, Sarah J. Ratcliffe, Mark E. Smolkin, Gestur Vidarsson, C. Ellen van der Schoot, Krystalyn E. Hudson, James C. Zimring

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

It has long been appreciated that immunoglobulins are not just the effector endpoint of humoral immunity, but rather have a complex role in regulating antibody responses themselves. Donor derived anti-RhD IgG has been used for over 50 years as an imm

Externí odkaz: https://doaj.org/article/5ced9a8f9c86426f90e7e02309b97636

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Akademický článek

Innate B-1 B Cells Are Not Enriched in Red Blood Cell Autoimmune Mice: Importance of B Cell Receptor Transgenic Selection

Autor: Amanda L. Richards, Heather L. Howie, Linda M. Kapp, Jeanne E. Hendrickson, James C. Zimring, Krystalyn E. Hudson

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Autoimmune hemolytic anemia (AIHA) results from breakdown of humoral tolerance to RBC antigens. Past analyses of B-cell receptor transgenic (BCR-Tg) mice that recognize RBC autoantigens led to a paradigm in which autoreactive conventional B-2 B cells

Externí odkaz: https://doaj.org/article/7e63e4d371154f0483dc997dc82b1e18

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Akademický článek

Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells

Autor: Karen de Wolski, Xiaoyoun Fu, Larry J. Dumont, John D. Roback, Hayley Waterman, Katherine Odem-Davis, Heather L. Howie, James C. Zimring

Publikováno v: Haematologica, Vol 101, Iss 5 (2016)

Transfusion of red blood cells is a very common inpatient procedure, with more than 1 in 70 people in the USA receiving a red blood cell transfusion annually. However, stored red blood cells are a non-uniform product, based upon donor-to-donor variat

Externí odkaz: https://doaj.org/article/304a1cf697f14b1a9f56528236486966

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