Výsledky vyhledávání - "Heather L. Evans-Marin"

Akademický článek

Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development.

Autor: Heather L Evans-Marin, Anthony T Cao, Suxia Yao, Feidi Chen, Chong He, Han Liu, Wei Wu, Maria G Gonzalez, Sara M Dann, Yingzi Cong

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134100 (2015)

T cells reactive to microbiota regulate the pathogenesis of inflammatory bowel disease (IBD). As T cell trafficking to intestines is regulated through interactions between highly specific chemokine-chemokine receptors, efforts have been made to devel

Externí odkaz: https://doaj.org/article/0bb56e5259414e2b932243e97eae744a

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Microbiota‐Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis

Autor: Heather L. Evans-Marin, Debbie M. Roeleveld, Shahla Abdollahi-Roodsaz, Jose U. Scher, Sergei B. Koralov, R. Rogier, Marije I. Koenders, Peter M. van der Kraan, Julia Manasson

Publikováno v: Arthritis & Rheumatology, 70, 12, pp. 1971-1983
Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & Rheumatology, 70, 1971-1983

Objective Intestinal microbiota are associated with the development of inflammatory arthritis. The aim of this study was to dissect intestinal mucosal immune responses in the preclinical phase of arthritis and determine whether the presence of Th17 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd27c596ce609867c9ee2c4d33fa67b4
https://doi.org/10.1002/art.40657

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Commensal A4 bacteria inhibit intestinal Th2-cell responses through induction of dendritic cell TGF-β production

Autor: Zhanju Liu, Heather L. Evans-Marin, Yingzi Cong, Mingming Sun, Han Liu, Ye Zhao, Wei Wu, Suxia Yao, Hou Pu Liu, L. Wayne Duck, Charles O. Elson, Feidi Chen, Anthony T. Cao, Qing Zhao

Publikováno v: European Journal of Immunology. 46:1162-1167

It has been shown that while commensal bacteria promote Th1, Th17 and Treg cells in lamina propria (LP) in steady-state conditions, they suppress mucosal Th2 cells. However, it is still unclear whether there are specific commensal organisms down-regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248777c73c1ac87ec4297b144dacf16b
https://doi.org/10.1002/eji.201546160

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THU0079 THE MICROBIOME OF NEW-ONSET RHEUMATOID ARTHRITIS (NORA) PATIENTS DRIVES TLR4-DEPENDENT TH17 RESPONSES

Autor: Marije I. Koenders, Heather L. Evans-Marin, P. Girija, R. Rogier, Shahla Abdollahi-Roodsaz, Joyce Aarts, Sergei B. Koralov, Julia Manasson, P.M. van der Kraan, Jose U. Scher

Publikováno v: Annals of the Rheumatic Diseases. 79:251.2-252

Background:Intestinal microbiota plays a prominent role in shaping the T cell immune response. Increasing evidence suggests that the gut microbiota is perturbed in patients with RA, and a variety of animal models demonstrated involvement of (mouse) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f2ce90964e6553d18b2d489664eb5de
https://doi.org/10.1136/annrheumdis-2020-eular.5269

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OP0329 Involvement of t helper 17 cells in inflammatory arthritis depends on the host intestinal microbiota

Autor: Heather L. Evans-Marin, R. Rogier, Marije I. Koenders, Debbie M. Roeleveld, Shahla Abdollahi-Roodsaz, Jose U. Scher

Publikováno v: Oral Presentations.

Background Intestinal microbiota have been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T helper 17 (Th17) cells. We therefore reasoned that the efficiacy of Th17-targeted ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c8c10fd07a34d997800b9c90665f2cb
https://doi.org/10.1136/annrheumdis-2017-eular.5522

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FRI0072 Alteration of the intestinal microbiome in the preclinical phase of experimental arthritis and the efficacy of microbiota modulation in established arthritis in mice

Autor: Marije I. Koenders, R. Rogier, P.M. van der Kraan, Jose U. Scher, Heather L. Evans-Marin, W.B. van den Berg, Shahla Abdollahi-Roodsaz

Publikováno v: Poster Presentations.

Background The composition of intestinal microbiota is perturbed in patients with new-onset rheumatoid arthritis (RA) and those with chronic RA. However, it is not known whether the changes in the intestinal microbiome precede the development of arth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29f6e7f84a1e3b2d3ae1ddaba1a847bf
https://doi.org/10.1136/annrheumdis-2017-eular.5533

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07.04 Partial elimination of intestinal microbiota dampens t helper 17 cell differentiation and established collagen-induced arthritis in mice

Autor: Fons A. J. van de Loo, Heather L. Evans-Marin, Peter M. van der Kraan, Birgitte Walgreen, R. Rogier, Marije I. Koenders, Shahla Abdollahi-Roodsaz, Monique M. Helsen, Peter L E M van Lent, Jose U. Scher, Liduine van den Bersselaar, Wim B. van den Berg

Publikováno v: Genes and environment.

Background/objectives Both germ-free condition and administration of oral antibiotics before the onset of arthritis modulate T cell differentiation and attenuate arthritis in mice. However, it is not known whether and how the modulation of intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74bb9b22cdd0b01cf528b672417a454c
https://doi.org/10.1136/annrheumdis-2016-211054.4

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Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis

Autor: Birgitte Walgreen, R. Rogier, Julia Manasson, Liduine van den Bersselaar, Fons A. J. van de Loo, Wim B. van den Berg, Marije I. Koenders, Steven B. Abramson, Peter M. van der Kraan, Jose U. Scher, Peter L E M van Lent, Monique M. Helsen, Shahla Abdollahi-Roodsaz, Heather L. Evans-Marin

Publikováno v: Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports

Perturbations of the intestinal microbiome have been observed in patients with new-onset and chronic autoimmune inflammatory arthritis. However, it is currently unknown whether these alterations precede the development of arthritis or are rather a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb4700c6b278a9b77632261420b6333
https://hdl.handle.net/2066/179543

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TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation

Autor: Yingzi Cong, Houpu Liu, Anthony T. Cao, Cathryn R. Nagler, Zhanju Liu, Andrew T. Stefka, Heather L. Evans-Marin, Hongwei Qin, Suxia Yao, Charles O. Elson

Publikováno v: Journal of Leukocyte Biology. 96:895-905

Tregs play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3+ Tregs accumulate in the inflamed lesions in experimental colitis and in IBD patients. Treg production of the proinflammatory cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41030e84a14f318a5cfffaff5b22faee
https://doi.org/10.1189/jlb.3a0114-056rr

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Microbiota Regulation of Inflammatory Bowel Disease

Autor: Heather L. Evans-Marin, Yingzi Cong

Publikováno v: Inflammation & Allergy-Drug Targets. 13:65-73

The intestines harbor over trillions of commensal bacteria, which co-evolve and form a mutualistic relationship with the host, with microbial-host interaction shaping immune adaption and bacterial communities. The intestinal microbiota not only benef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b3281ad3ad2789547b23706dae5984
https://doi.org/10.2174/1871528113666140118202140

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