Výsledky vyhledávání - "Heather L Schuback"

Supplemental Figure 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

Demographic Information of Patient Cohort. A) Age category of patients. B) Cytogenetic category.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5073cf6db09b01277dbc1eb3e614631c
https://doi.org/10.1158/0008-5472.22410521.v1

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Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

Patient Characteristics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1730c4808a820a6068d5be1f2e47d6
https://doi.org/10.1158/0008-5472.22410509

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Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

List of all segment variations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21d77850adb8344d7aeb4f0c594fc83
https://doi.org/10.1158/0008-5472.22410503

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Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

Clonal cluster analysis. Mutations were clustered using DBSCAN based on the VAF and graphed according to timepoint. Panels A-T illustrate possible scenarios of how individual mutations may originate, evolve, and resolve based on VAF.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa9f69b815765f6fabdb41f9b5be176
https://doi.org/10.1158/0008-5472.22410512

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Supplemental Figure 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

Clonal evolution of mutations from diagnosis to relapse. These graphs depict the Variant Allele Frequency (VAF) of each patient's mutations at diagnosis and relapse. Note: Mutations absent at diagnosis or relapse are depicted with VAF of zero. Gene n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec810271ec787c2a63ed9eb89e084a4
https://doi.org/10.1158/0008-5472.22410515.v1

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Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

List of all verified mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6022b2319c98a06948b71d603d02d9f9
https://doi.org/10.1158/0008-5472.22410506.v1

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Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

Publikováno v: Cancer research. 76(8)

The genomic and clinical information used to develop and implement therapeutic approaches for acute myelogenous leukemia (AML) originated primarily from adult patients and has been generalized to patients with pediatric AML. However, age-specific mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5769382bff1d5005bcfed063e3504b73
https://pubmed.ncbi.nlm.nih.gov/26941285

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CBFA2T3-GLIS2 Fusion Is Prevalent in Younger Patients with Acute Myeloid Leukemia and Associated with High-Risk of Relapse and Poor Outcome: A Children’s Oncology Group Report

Autor: Richard Aplenc, Amy Heerema-McKenney, Kristen L. Miller, Susana C. Raimondi, Soheil Meshinchi, Betsy A. Hirsch, Robert B. Gerbing, Samir B. Kahwash, Heather L Schuback, Todd A. Alonzo, Alan S. Gamis

Publikováno v: Blood. 124:13-13

The cryptic CBA2T3-GLIS2 fusion generated by the inv(16)(p13.3q24.3) was initially identified in megakaryocytic leukemia and later implicated in other acute myeloid leukemia (AML) subtypes. Presence of this fusion may lead to altered expression of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba061981fc3a6bbec2c500ef900e9b71
https://doi.org/10.1182/blood.v124.21.13.13

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