Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Heather L Parrish"'
Autor:
Mark S Lee, Peter J Tuohy, Caleb Y Kim, Philip P Yost, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
Publikováno v:
eLife, Vol 12 (2024)
CD4+ T cell activation is driven by five-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling module
Externí odkaz:
https://doaj.org/article/e90d0627576a424cb17384af3076cd76
Autor:
Mark S Lee, Peter J Tuohy, Caleb Y Kim, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
Publikováno v:
eLife, Vol 11 (2022)
CD4+ T cells use T cell receptor (TCR)–CD3 complexes, and CD4, to respond to peptide antigens within MHCII molecules (pMHCII). We report here that, through ~435 million years of evolution in jawed vertebrates, purifying selection has shaped motifs
Externí odkaz:
https://doaj.org/article/ee02f986cdcb478ea9094352a35c5524
Autor:
Heather L Parrish, Caleb R Glassman, Madeline M Keenen, Neha R Deshpande, Matthew P Bronnimann, Michael S Kuhns
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150876 (2016)
Externí odkaz:
https://doaj.org/article/7effbf4322de4f2f945e7aa920a526a2
Publikováno v:
eLife, Vol 4 (2015)
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4+ T-cell compartment to bind self- and foreign-pMHC changes over the
Externí odkaz:
https://doaj.org/article/39ce88f28202492da7e89724c9b008bc
Autor:
Heather L Parrish, Caleb R Glassman, Madeline M Keenen, Neha R Deshpande, Matthew P Bronnimann, Michael S Kuhns
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132333 (2015)
CD4 interactions with class II major histocompatibility complex (MHC) molecules are essential for CD4+ T cell development, activation, and effector functions. While its association with p56lck (Lck), a Src kinase, is important for these functions CD4
Externí odkaz:
https://doaj.org/article/79b89e2d99744b9a8f4351238c1166a5
Autor:
Mark S. Lee, Peter J. Tuohy, Caleb Y. Kim, Philip P. Yost, Katrina Lichauco, Heather L. Parrish, Koenraad Van Doorslaer, Michael S. Kuhns
CD4+T cell activation is driven by 5-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14564fc5ec47a4b6e4f8898f9ce5494
https://doi.org/10.1101/2023.05.05.539613
https://doi.org/10.1101/2023.05.05.539613
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(10)
T cells play a central role in adaptive immunity by recognizing peptide Ags presented by MHC molecules (pMHC) via their clonotypic TCRs. αβTCRs are heterodimers, consisting of TCRα and TCRβ subunits that are composed of variable (Vα, Vβ) and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94329f179ad78942856d08e401f75cad
https://pubmed.ncbi.nlm.nih.gov/36426940
https://pubmed.ncbi.nlm.nih.gov/36426940
T-cells play a central role in adaptive immunity by recognizing peptide-antigens presented in MHC molecules (pMHC) via their clonotypic T-cell receptors (TCRs). αβTCRs are heterodimers, consisting of TCRα and TCRβ subunits that are composed of va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aff12a154029203a36eb27a347a5c9a
https://doi.org/10.1101/2022.05.24.493299
https://doi.org/10.1101/2022.05.24.493299
Autor:
Monika A. Niewczas, Mark S. Lee, Martin A. Thelin, Heather L. Parrish, Alborz Karimzadeh, Neha R. Deshpande, Thomas Serwold, Shio Kobayashi, Michael S. Kuhns
Publikováno v:
Proc Natl Acad Sci U S A
T cells express clonotypic T cell receptors (TCRs) that recognize peptide antigens in the context of class I or II MHC molecules (pMHCI/II). These receptor modules associate with three signaling modules (CD3γε, δε, and ζζ), and work in concert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1aeb34b344f7b17f7e57142d2db538