Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Heather L Machado"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Breast tumorigenesis relies on complex interactions between tumor cells and their surrounding microenvironment, orchestrated by tightly regulated transcriptional networks. C/EBPβ is a key transcription factor that regulates the proliferation and dif
Externí odkaz:
https://doaj.org/article/b96b09612f8a473890d8ea6e75c0eb46
Autor:
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Yunah Kim, Emmanuelle Ruiz, Emad Kandil, Heather L. Machado, Suzana D. Savkovic
Publikováno v:
Metabolites, Vol 12, Iss 3, p 250 (2022)
Obesity, characterized by augmented inflammation and tumorigenesis, is linked to genetic predispositions, such as FOXO3 polymorphisms. As obesity is associated with aberrant macrophages infiltrating different tissues, including the colon, we aimed to
Externí odkaz:
https://doaj.org/article/8360caa076894cf0a3351031caf80f12
Autor:
Ayman M. Ibrahim, Matthew A. Moss, Zane Gray, Michelle D. Rojo, Caitlin M. Burke, Kathryn L. Schwertfeger, Camila O. dos Santos, Heather L. Machado
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Myeloid cell heterogeneity remains poorly studied in breast cancer, and particularly in premalignancy. Here, we used single cell RNA sequencing to characterize macrophage diversity in mouse pre-invasive lesions as compared to lesions undergoing local
Externí odkaz:
https://doaj.org/article/b4a1669710614bc09b7acf844aab3c82
Autor:
Ying Wang, Thomas S Chaffee, Rebecca S LaRue, Danielle N Huggins, Patrice M Witschen, Ayman M Ibrahim, Andrew C Nelson, Heather L Machado, Kathryn L Schwertfeger
Publikováno v:
eLife, Vol 9 (2020)
Tissue-resident macrophages in the mammary gland are found in close association with epithelial structures and within the adipose stroma, and are important for mammary gland development and tissue homeostasis. Macrophages have been linked to ductal d
Externí odkaz:
https://doaj.org/article/b6cd20f4110c43bd9da5cbeb9507aef0
Autor:
Kylie L Mills, Angelica M Gomes, Courtney R Standlee, Michelle D Rojo, Peter Carmeliet, Zhen Lin, Heather L Machado
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208550 (2018)
Mammary gland development is a complex and dynamic process that occurs mainly postnatally. Ductal elongation and branching morphogenesis are regulated by a plethora of factors, including cytokines, hormones, growth factors and the extracellular matri
Externí odkaz:
https://doaj.org/article/8e94b03588c14fdf8e336603a4a60e3a
Autor:
Michelle D. Rojo, Caitlin M. Burke, Alexa M. Dow, Kathryn L. Schwertfeger, Heather L. Machado
Publikováno v:
Cancer Research. 82:3162-3162
Throughout mammary gland development, there are distinct stages that are “hot spots” of breast cancer risk. During these critical windows, tissue resident macrophages function to maintain the homeostatic balance within the stromal microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0627614af63cfc254336dece7121c0
https://doi.org/10.1158/1538-7445.am2022-3162
https://doi.org/10.1158/1538-7445.am2022-3162
Autor:
Darby R. Graham, Kelly D. Hebert, Emma E. Newton, Angelica M. Gomes, Fariba Behbod, Heather L. Machado
Publikováno v:
Cancer Research. 82:861-861
Axl is a receptor tyrosine kinase (RTK) that is activated by its ligand Gas6 and regulates proliferation, cell survival, and clearance of apoptotic cells in both normal physiology and a number of disease states. In breast cancer, Axl is overexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd0543bbc43fc46037aeb186e710965
https://doi.org/10.1158/1538-7445.am2022-861
https://doi.org/10.1158/1538-7445.am2022-861
Autor:
Ashkan Shahbandi, Fang-Yen Chiu, Nathan A. Ungerleider, Ashlyn Y. Anderson, Heather L. Machado, Zachary F. Pursell, Raegan Kvadas, Sonia G. Rao, James G. Jackson
Publikováno v:
Cancer Research. 82:1297-1297
We and others have previously shown that the breast cancers most difficult to eradicate with chemotherapy are TP53 wild-type, and these are among the most lethal breast cancers. For instance, chemotherapy-treated TNBC patients with TP53 wild-type tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b1f418b72ee834d54bfe96b4802759
https://doi.org/10.1158/1538-7445.am2022-1297
https://doi.org/10.1158/1538-7445.am2022-1297
Publikováno v:
Cancer Research. 82:933-933
Breast cancer growth and progression relies on complex interactions between tumor cells and surrounding stromal cells, including immune cells. Infiltrating immune cells, including macrophages, have been shown to promote tumor progression and metastas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18dde01423feb02facfb1ed13561c643
https://doi.org/10.1158/1538-7445.am2022-933
https://doi.org/10.1158/1538-7445.am2022-933
Autor:
Caitlin M. Burke, Michelle D. Rojo, Jeffery M. Rosen, Tobias Ackermann, Christine Muller, Cornelis F. Calkhoven, Heather L. Machado
Publikováno v:
Cancer Research. 82:915-915
Breast tumorigenesis relies on complex interactions between tumor cells and their surrounding environment, orchestrated by tightly regulated transcriptional networks. While much is known about the signaling pathways affecting breast cancer cell growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f88a1f1f187ce59da80a305fdb04cf
https://doi.org/10.1158/1538-7445.am2022-915
https://doi.org/10.1158/1538-7445.am2022-915