Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Heather L Gardner"'
Autor:
Katherine Dittrich, Ümmügülsüm Yıldız-Altay, Fatima Qutab, Danny A Kwong, Zechuan Rao, Sebastian A Nievez-Lozano, Heather L Gardner, Jillian M Richmond, Cheryl A London
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290428 (2023)
Pet dogs develop spontaneous diffuse large B cell lymphoma (DLBCL), and veterinary clinical trials have been employed to treat canine DLBCL and to inform clinical trials for their human companions. A challenge that remains is selection of treatment t
Externí odkaz:
https://doaj.org/article/c3e092a2d8ea4b18bd9e6af5fc3eab48
Autor:
Kate Megquier, Jason Turner-Maier, Kathleen Morrill, Xue Li, Jeremy Johnson, Elinor K Karlsson, Cheryl A London, Heather L Gardner
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274383 (2022)
The characterization of immortalized canine osteosarcoma (OS) cell lines used for research has historically been based on phenotypic features such as cellular morphology and expression of bone specific markers. With the increasing use of these cell l
Externí odkaz:
https://doaj.org/article/141e55c5532a44ba85cdda09c7b40708
Autor:
Heather L Gardner, Sarah B Rippy, Misty D Bear, Kim L Cronin, Heather Heeb, Holly Burr, Claire M Cannon, Kumar V Penmetsa, Srikant Viswanadha, Swaroop Vakkalanka, Cheryl A London
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195357 (2018)
RV1001 is a novel, potent, and selective PI3Kδ inhibitor. The purpose of this study was to evaluate the safety and efficacy of RV1001 in canine Non-Hodgkin lymphoma (NHL).Inhibition of endogenous pAKT by RV1001 in primary canine NHL cells was determ
Externí odkaz:
https://doaj.org/article/2cde8c7101d8458aaeb72cfb3d0632c4
Autor:
Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181885 (2017)
STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a n
Externí odkaz:
https://doaj.org/article/1e0e13539a7340a3a783709d729e834f
Autor:
Gretchen P. McLinden, Anne C. Avery, Heather L. Gardner, Kelly Hughes, Angie M. Rodday, Kexuan Liang, Cheryl A. London
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 3, Pp 1666-1674 (2024)
Abstract Background To explore the safety and utility of combining low dose single‐agent doxorubicin with a canine specific anti‐CD20 monoclonal antibody (1E4‐cIgGB) in client owned dogs with untreated B‐cell lymphoma. Animals Forty‐two cli
Externí odkaz:
https://doaj.org/article/298dea408eb844359dba10c2e4026ea5
Autor:
Bonnie K Harrington, Heather L Gardner, Raquel Izumi, Ahmed Hamdy, Wayne Rothbaum, Kevin R Coombes, Todd Covey, Allard Kaptein, Michael Gulrajani, Bart Van Lith, Cecile Krejsa, Christopher C Coss, Duncan S Russell, Xiaoli Zhang, Bridget K Urie, Cheryl A London, John C Byrd, Amy J Johnson, William C Kisseberth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159607 (2016)
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency compared to ibrutinib. In this study, we evaluated acalabrutinib in spontaneously occurring cani
Externí odkaz:
https://doaj.org/article/885fb92964b3445a99b5a10f0adb8206
Autor:
Cheryl A London, Heather L Gardner, Tamra Mathie, Nicole Stingle, Roberta Portela, Michael L Pennell, Craig A Clifford, Mona P Rosenberg, David M Vail, Laurel E Williams, Kim L Cronin, Heather Wilson-Robles, Antonella Borgatti, Carolyn J Henry, Dennis B Bailey, Jennifer Locke, Nicole C Northrup, Martin Crawford-Jakubiak, Virginia L Gill, Mary K Klein, David M Ruslander, Doug H Thamm, Brenda Phillips, Gerald Post
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124889 (2015)
We hypothesized that the addition of toceranib to metronomic cyclophosphamide/piroxicam therapy would significantly improve disease-free interval (DFI) and overall survival (OS) in dogs with appendicular osteosarcoma (OSA) following amputation and ca
Externí odkaz:
https://doaj.org/article/a53bde96293544248c55b1e08df0a365
Autor:
Jadesola Temitope Olayinka, Akanksha Nagarkar, Diana Junyue Ma, Neil B. Wong, Andrew Romasco, Cesar Piedra-Mora, Linda Wrijil, Clement N. David, Heather L. Gardner, Nicholas A. Robinson, Kelly L. Hughes, Bruce Barton, Cheryl A. London, Ramón M. Almela, Jillian M. Richmond
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Cutaneous T-cell lymphoma (CTCL) is an uncommon type of lymphoma involving malignant skin-resident or skin-homing T cells. Canine epitheliotropic lymphoma (EL) is the most common form of CTCL in dogs, and it also spontaneously arises from T lymphocyt
Externí odkaz:
https://doaj.org/article/073a508055a14180ac8f458d7bea2ad7
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-7 (2019)
Abstract Background Oclacitinib is an orally bioavailable Janus Kinase (JAK) inhibitor approved for the treatment of canine atopic dermatitis. Aberrant JAK/ Signal Transducer and Activator of Transcription (STAT) signaling within hematologic and soli
Externí odkaz:
https://doaj.org/article/b3540c6a70c34a788966a76f1d284b6d
Publikováno v:
BMC Veterinary Research, Vol 13, Iss 1, Pp 1-9 (2017)
Abstract Background Hyperthermia is an established anti-cancer treatment but is limited by tolerance of adjacent normal tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyperthermia treatment whi
Externí odkaz:
https://doaj.org/article/b27046c549ba4175a137265793bd37a0