Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Heather L Drexler"'
Autor:
Allison Coté, Aoife O'Farrell, Ian Dardani, Margaret Dunagin, Chris Coté, Yihan Wan, Sareh Bayatpour, Heather L Drexler, Katherine A Alexander, Fei Chen, Asmamaw T Wassie, Rohan Patel, Kenneth Pham, Edward S Boyden, Shelly Berger, Jennifer Phillips-Cremins, L Stirling Churchman, Arjun Raj
Publikováno v:
eLife, Vol 12 (2024)
Splicing is the stepwise molecular process by which introns are removed from pre-mRNA and exons are joined together to form mature mRNA sequences. The ordering and spatial distribution of these steps remain controversial, with opposing models suggest
Externí odkaz:
https://doaj.org/article/e2adfd4a05a34bda852301bfb43444b5
Autor:
Karine Choquet, Hope E. Merens, Heather L. Drexler, Paul S. Tang, L. Stirling Churchman, Jared T. Simpson
Publikováno v:
Nat Protoc
During maturation, eukaryotic precursor RNAs undergo processing events including intron splicing, 3’-end cleavage, and polyadenylation. Here, we describe nanopore analysis of CO-transcriptional Processing (nano-COP), a method for probing the timing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1faf809a5d926c324605648892d77e4
https://doi.org/10.1038/s41596-020-00469-y
https://doi.org/10.1038/s41596-020-00469-y
Autor:
Allison Cote, Katherine A. Alexander, Edward S. Boyden, Arjun Raj, Heather L. Drexler, Sareh Bayatpour, L. Stirling Churchman, Christopher Coté, Fei Chen, Shelley L. Berger, Asmamaw T Wassie
Splicing is the molecular process by which introns are removed from pre-mRNA and exons are joined together to form the sequence of the mature mRNA. While the biochemical steps of splicing have been largely worked out, the ordering and spatial distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e5a4b6427e97a281ef3cee7e76d4c6
https://doi.org/10.1101/2020.04.06.028092
https://doi.org/10.1101/2020.04.06.028092
Publikováno v:
Mol Cell
Understanding how splicing events are coordinated across numerous introns in metazoan RNA transcripts requires quantitative analyses of transient RNA processing events in living cells. We developed nanopore analysis of co-transcriptional processing (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94bee0c4bb71f71b6c76b7bb3c1924d
https://pubmed.ncbi.nlm.nih.gov/31839405
https://pubmed.ncbi.nlm.nih.gov/31839405
Human genes have numerous exons that are differentially spliced within pre-mRNA. Understanding how multiple splicing events are coordinated across nascent transcripts requires quantitative analyses of transient RNA processing events in living cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66111550fb72fe64e359210b7ecadc71
https://doi.org/10.1101/611020
https://doi.org/10.1101/611020