Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Heather Kayew Mak"'
Autor:
Jing Wu, Heather Kayew Mak, Yau Kei Chan, Chen Lin, Cihang Kong, Christopher Kai Shun Leung, Ho Cheung Shum
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Glaucoma is a leading cause of blindness characterized by progressive degeneration of retinal ganglion cells (RGCs). A well-established risk factor for the development and progression of glaucoma is elevation of intraocular pressure (IOP). H
Externí odkaz:
https://doaj.org/article/6f0568a649344552903dab995dc4dfa5
Autor:
Huayu Qi, Ingrid Li, Kit Li, Robin M. Hobbs, Lin Gao, Wai-Yee Chan, Hei Wan Hou, Xiaohua Jiang, Wing Tung Lee, Chun Shui Luk, Bo Feng, Kai Shun Leung, Judy Kin Wing Ng, Yuen Hang Liu, John A. Rudd, Tin-Lap Lee, Thomas Ting Hei Chan, Tsz Kin Ng, Yan Qian, Jinyue Liao, Hoi Ching Suen, Heather Kayew Mak
Publikováno v:
Stem Cells and Development. 28:1365-1375
Glaucoma is characterized by retinal ganglion cell (RGC) degeneration and is the second leading cause of blindness worldwide. However, current treatments such as eye drop or surgery have limitations and do not target the loss of RGC. Regenerative the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c79896b27549c261561ccecd97e36b
https://doi.org/10.1089/scd.2019.0060
https://doi.org/10.1089/scd.2019.0060
Autor:
Kevin C. Chan, Xu Cao, Tianmin Ren, Yu Yu, Jasmine Sum Yee Yung, Yolandi van der Merwe, Shuk Han Ng, Christopher Kai-Shun Leung, Heather Kayew Mak, Ying Chau, Yolanda W. Y. Yip, Sayantan Biswas
Publikováno v:
Acta Biomater
Investigation of neurodegeneration in glaucoma, a leading cause of irreversible blindness worldwide, has been obfuscated by the lack of an efficient model that provides chronic, mild to moderate elevation of intraocular pressure (IOP) with preservati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cb72fddf7ba26fbdb0ff8886f57a83
https://doi.org/10.1016/j.actbio.2019.06.005
https://doi.org/10.1016/j.actbio.2019.06.005
Autor:
Xu Cao, Jasmine Sum Yee Yung, Wing-Ho Yung, Shuk Han Ng, Tracy Y.C. Ho, Tin-Lap Lee, Tsz Kin Ng, Heather Kayew Mak, Chi Chiu Wang, Kwong Wai Choy, Christopher Kai-Shun Leung, Wai Kit Chu, Robert N. Weinreb
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 251-263 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbb93ad16bf4899d6a61c7629dededb
https://escholarship.org/uc/item/7h35j468
https://escholarship.org/uc/item/7h35j468
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 16, Iss 10, Pp 1996-1997 (2021)
Neural Regeneration Research, Vol 16, Iss 10, Pp 1996-1997 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5ab0a5ee7bd932dfdd93911d3f9e5c
https://doi.org/10.4103/1673-5374.308081
https://doi.org/10.4103/1673-5374.308081
Autor:
Ken Wu, Timothy P H Cheng, Christopher Kai-Shun Leung, Xiu Juan Zhang, Alexander Lam, Robert N. Weinreb, Philip Yawen Guo, Gilda Lai, Vivian Chiu, Heather Kayew Mak, Elaine To, Marco Yu
Publikováno v:
JAMA Ophthalmol
Importance Clinical assessment of vision-related disability is hampered by the lack of instruments to assess visual performance in real-world situations. Interactive virtual reality (VR) environments displayed in a binocular stereoscopic VR headset h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a964f41a15cb07c0c3aea33936755a71
https://doi.org/10.1001/jamaophthalmol.2020.0391
https://doi.org/10.1001/jamaophthalmol.2020.0391
Publikováno v:
Experimental Eye Research. 192:107938
Retinal ganglion cell (RGC) degeneration, leading to irreversible blindness in chronic optic neuropathies, commonly begins with dendritic shrinkage followed by axon degeneration. Although limited axon regeneration in the optic nerve is possible with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d1e3724c838072cca6904fb3c5b252
https://doi.org/10.1016/j.exer.2020.107938
https://doi.org/10.1016/j.exer.2020.107938
Publikováno v:
Gene therapy. 26(3-4)
Efficient transduction of the retinal ganglion cells (RGCs) is a prerequisite to maximize therapeutic outcomes in any form of gene therapy for optic neuropathies. Whereas subretinal injection of adeno-associated virus 2 (AAV2) has been well-character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b0e2e752d657af0df5e4a89ffbf0dd
https://pubmed.ncbi.nlm.nih.gov/30692605
https://pubmed.ncbi.nlm.nih.gov/30692605
Autor:
Marco Yu, Christopher Kai-Shun Leung, Heather Kayew Mak, Chen Lin, Michael J. Crowther, Zhongheng Wu
Publikováno v:
Investigative ophthalmologyvisual science. 58(3)
Purpose To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma. Methods One hundred forty-six eyes of 95 glaucoma pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca6a5dc58861f67dfd65f241856aab5
https://pubmed.ncbi.nlm.nih.gov/28353690
https://pubmed.ncbi.nlm.nih.gov/28353690
Publikováno v:
JAMA ophthalmology. 135(3)
Importance Measurement of the rates of retinal nerve fiber layer (RNFL) thinning has consisted primarily of the circumpapillary RNFL profile. This study reports the rates of RNFL thinning over the 6 × 6 mm 2 RNFL thickness map and their application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3420bb856fd1ae4edfe455c8dcac10dd
https://pubmed.ncbi.nlm.nih.gov/28152147
https://pubmed.ncbi.nlm.nih.gov/28152147