Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Heather K, Kroh"'
Autor:
Victoria H. Ng, Zachary Spencer, Leif R. Neitzel, Anmada Nayak, Matthew A. Loberg, Chen Shen, Sara N. Kassel, Heather K. Kroh, Zhenyi An, Christin C. Anthony, Jamal M. Bryant, Amanda Lawson, Lily Goldsmith, Hassina Benchabane, Amanda G. Hansen, Jingjing Li, Starina D’Souza, Andres M. Lebensohn, Rajat Rohatgi, William A. Weiss, Vivian L. Weiss, Charles Williams, Charles C. Hong, David J. Robbins, Yashi Ahmed, Ethan Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt receptors are well-characterized, the deubiquitylase that re
Externí odkaz:
https://doaj.org/article/ef64ae66e0614f03b079cfeb3260d710
Autor:
Shannon L Kordus, Heather K Kroh, Rubén Cano Rodríguez, Rebecca A Shrem, F Christopher Peritore-Galve, John A Shupe, Brian E Wadzinski, D Borden Lacy, Benjamin W Spiller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011496 (2023)
Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and Tc
Externí odkaz:
https://doaj.org/article/5c0a09492fa445118a189e4830bc1d37
Autor:
Heather K. Kroh, Stacey A. Rutherford, Simoun Icho, Roman A. Melnyk, Casey M. Theriot, D. Borden Lacy, Evelyn Utama, John Kit Chung Tam, Rodolfo F. Gómez-Biagi, Kathleen E. Orrell
Publikováno v:
Proc Natl Acad Sci U S A
Significance Clostridioides difficile is a bacterial pathogen of global importance that is a major cause of hospital-acquired diarrhea. Antibiotic-mediated disruptions to the gut microbiota and associated metabolome promote C. difficile growth and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d3b3b06f70eb6fef56779047f23233
https://doi.org/10.1073/pnas.1916965117
https://doi.org/10.1073/pnas.1916965117
Autor:
F. Christopher Peritore-Galve, Audrey K. Thomas, Heather K. Kroh, John A. Shupe, M. Kay Washington, Sarah C. Bloch, Erin N. Laubacher, D. Borden Lacy, Kevin O. Childress, Robert J. Coffey, Nicholas O. Markham
Publikováno v:
Infection and Immunity. 89
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd395deb9860a8157017ce04d07c27d
https://doi.org/10.1128/iai.00543-20
https://doi.org/10.1128/iai.00543-20
Autor:
Nicholas O, Markham, Sarah C, Bloch, John A, Shupe, Erin N, Laubacher, Audrey K, Thomas, Heather K, Kroh, Kevin O, Childress, F Christopher, Peritore-Galve, M Kay, Washington, Robert J, Coffey, D Borden, Lacy
Publikováno v:
Infect Immun
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8d82289e996b44c13295aade81ef64e
https://pubmed.ncbi.nlm.nih.gov/33468584
https://pubmed.ncbi.nlm.nih.gov/33468584
Autor:
Ashoka A. Maddur, Breanne H.Y. Gibson, Mary E. Aschenbrenner, Peter Panizzi, Paul E. Bock, Jonathan H. Sheehan, Ingrid M. Verhamme, Jens Meiler, Heather K. Kroh
Publikováno v:
J Biol Chem
In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784daea48caa6095f991ef564fa9bf71
https://pubmed.ncbi.nlm.nih.gov/32156702
https://pubmed.ncbi.nlm.nih.gov/32156702
Autor:
Roman A. Melnyk, Ramyavardhanee Chandrasekaran, D.B. Lacy, Xiaofang Jin, Zhifen Zhang, Godfrey Rainey, Andrew C. Nyborg, Ben Spiller, Heather K. Kroh, Paul Warrener, Kim Rosenthal, Robert M. Woods
Publikováno v:
Journal of Biological Chemistry. 293:941-952
Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins perturb host cell function through a multistep process of receptor binding, endocytosis, low pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf822b7b7856be7d7def3a46ef4e5a71
https://doi.org/10.1074/jbc.m117.813428
https://doi.org/10.1074/jbc.m117.813428
Autor:
Kavitha Bekkari, Pulkit Gupta, Nicholas Murgolo, Heather K. Kroh, Swetha Raman, Zhifen Zhang, Lorraine D. Hernandez, Roman A. Melnyk, Jean-Phillipe Julien, John Kit Chung Tam, D. Borden Lacy, Alex G. Therien, Seiji Sugiman-Marangos
Publikováno v:
Journal of Biological Chemistry. 292:17290-17301
Clostridium difficile is a major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the primary determinant in human disease. TcdA and TcdB are large, multidomain proteins, each harboring a cytotoxic glucosyltrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b131dfbed3b93ebf6b2704ce677ddfef
https://doi.org/10.1074/jbc.m117.806687
https://doi.org/10.1074/jbc.m117.806687
Autor:
D. Borden Lacy, Heather K. Kroh, Benjamin W. Spiller, Melanie D. Ohi, G. Jonah A. Rainey, Kim Rosenthal, Robert M. Woods, Paul Warrener, Ramyavardhanee Chandrasekaran, Xiaofang Jin, Andrew C. Nyborg
Publikováno v:
Journal of Biological Chemistry. 292:14401-14412
Clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. Disease symptoms stem from the activities of two large, multidomain toxins known as TcdA and TcdB. The toxins can bind, ente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42977e095715ba064409a76e43494d03
https://doi.org/10.1074/jbc.m117.781112
https://doi.org/10.1074/jbc.m117.781112
Autor:
Nicholas S. Heaton, Donghai Wang, Katherine A. Fitzgerald, Heather K. Kroh, Zhaozhao Jiang, David Miao, Michael Glogauer, Shigao Yang, Connie Zhou, Catherine Sweeney, Chunxiang Sun, Loretta G. Que, Gregory Swan, Gianna E. Hammer, D. Borden Lacy, Alfred T. Harding, Martin O. Bergo
Publikováno v:
Science Advances
Protein geranylgeranylation limits antiviral innate immunity.
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc52b18d471e0c08644b1dbc0536fcf
https://doi.org/10.1126/sciadv.aav7999
https://doi.org/10.1126/sciadv.aav7999