Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Heather K, Knych"'
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionMorphine is an effective analgesic in horses, however, IV administration at therapeutic doses has been shown to produce dose-dependent neuroexcitation and unwanted gastrointestinal effects. The analgesic effects of morphine have, at least
Externí odkaz:
https://doaj.org/article/9f7c4b7e2ede4f40b5ac1f93062d086a
Autor:
Vaidehi V. Paranjape, Heather K. Knych, Londa J. Berghaus, Shyla Giancola, Jessica Cathcart, Rachel A. Reed
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
BackgroundAnatomical location-dependent differences in transdermal opioid penetration are well described in human patients. Although this has been investigated in horses with fentanyl, there is no literature available on location-dependent plasma bup
Externí odkaz:
https://doaj.org/article/a4340a44cc0c4a35b210c5327912b725
Autor:
Kimberly L. Hallowell, Katarzyna Dembek, Caitlyn R. Horne, Heather K. Knych, Kristen M. Messenger, Lauren V. Schnabel
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Steroid-associated laminitis remains a major concern with use of corticosteroids in horses. Individual case factors such as joint pathology, pre-existing endocrinopathies, or corticosteroid type, dose, and timing influencing steroid-induced laminitis
Externí odkaz:
https://doaj.org/article/33c5605e379c4f0184a7e6df1ad14b62
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionDosing recommendations for hydromorphone intravenous constant rate infusion (IV CRI) are derived from simulations following IV bolus administration. While this extrapolated dose regimen has been described clinically, pharmacokinetics (PK)
Externí odkaz:
https://doaj.org/article/fd73c384309e4885893c8b9833811079
Autor:
Rachel A. Reed, Londa J. Berghaus, Rose M. Reynolds, Brittany T. Holmes, Anna M. Krikorian, Daniel M. Sakai, Yushun Ishikawa, Heather K. Knych
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
IntroductionUnderstanding the pharmacokinetics and pharmacodynamics of fentanyl in horses is crucial for optimizing pain management strategies in veterinary medicine.MethodsSix adult horses were enrolled in a randomized crossover design. Treatments i
Externí odkaz:
https://doaj.org/article/b6a5009858764deeb6260ec8339d7631
Autor:
Vaidehi V. Paranjape, Heather K. Knych, Londa J. Berghaus, Jessica Cathcart, Shyla Giancola, Hannah Craig, Caroline James, Siddharth Saksena, Rachel A. Reed
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
BackgroundMatrix type transdermal buprenorphine patches have not been investigated in horses and may provide an effective means of providing continuous pain control for extended period and eliminating venous catheterization.ObjectiveAssessment of the
Externí odkaz:
https://doaj.org/article/5ee3b3aaf76f412595c36b475098b3a8
Autor:
Danielle M. Zwueste, Karen M. Vernau, William Vernau, Bruno H. Pypendop, Heather K. Knych, Carlos A. Rodrigues, Amir Kol, Maria Questa, Peter J. Dickinson
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2429-2442 (2023)
Abstract Background Cytosine arabinoside (Ara‐C) is a nucleoside analog prodrug utilized for immunomodulatory effects mediated by its active metabolite Ara‐CTP. Optimal dosing protocols for immunomodulation in dogs have not been defined. Cytarabi
Externí odkaz:
https://doaj.org/article/79a62cc71e4141b481770e15f2321627
Publikováno v:
BMC Veterinary Research, Vol 19, Iss 1, Pp 1-9 (2023)
Abstract Background Lidocaine is a local anesthetic that is sometimes administered in combination with epinephrine. The addition of epinephrine increases the time lidocaine remains at the site of administration, thus prolonging the duration of effect
Externí odkaz:
https://doaj.org/article/56220ed0f639447aa015ed282ea818c9
Autor:
Payam Vali, Peggy Chen, Evan Giusto, Amy Lesneski, Morgan E. Hardie, Heather K. Knych, Deepika Sankaran, Ziad Alhassen, Houssam M. Joudi, Satyan Lakshminrusimha
Publikováno v:
Children, Vol 11, Iss 5, p 527 (2024)
Background: An umbilical venous catheter (UVC) is the preferred route of epinephrine administration during neonatal resuscitation but requires specialized equipment, expertise, and time. Hypothesis: Direct injection of epinephrine into the umbilical
Externí odkaz:
https://doaj.org/article/06b76010021a4e67aaa6b42bf9dda611
Publikováno v:
BMC Veterinary Research, Vol 18, Iss 1, Pp 1-12 (2022)
Abstract Background Intra-articular corticosteroids, such as isoflupredone acetate, are commonly used in the treatment of joint inflammation, especially in performance horses. Following administration in a non-inflamed joints blood concentrations of
Externí odkaz:
https://doaj.org/article/891874bbc184456091bc36515244cdf6